Heeseon An: Publications

Independent.  #:equal contribution, underline: An lab members, *: corresponding author

9. 5-tBu-thalidomide is a potent and selective molecular glue degrader of the transcription factor FLT3 interacting zinc finger 1 (FIZ1). 

Brennan PJ^#, Guo R^#, Ordureau A, Singleton SE, Li M, Albayrak F, Liao LY, Deane CM, Houk KN, Hann MM, Brayshaw LL, An H^*, Conway SJ^*

J. Am. Chem. Soc. (2026) Accepted

8. Comprehensive Chemoproteomics Unveils Selective HMGCS1 Inhibitors for Targeting Mevalonate Metabolism in Cancer. 

Sun L^#, Yi SA^#, Pham BQ, Mocellin A, Sen S, de la Cruz MJ, Ordureau A, An H^* 

J. Am. Chem. Soc. (2026) 148, 20705.

7. Proteomic Profiling Reveals How Physiological Media Reshape Cancer Cell Proteomes and Signaling Networks.

Zenge C^#, Pham BQ^#, Nam K, Apfelbaum E, An H^*, Ordureau A^*

Molecular Cell Proteomics (2026) 25, 101569.

6. Activity-based probes and chemical proteomics uncover the biological impact of targeting HMGCS1 in the mevalonate pathway.

Yi SA^#, Sun L^#, Rao Y, Ordureau A, Lewis JS, An H^*

J. Biol. Chem. (2025) 301, 110660.

5. mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase.

Pham BQ, Yi SA, Ordureau A, An H^* 

Cell Reports (2025) 44, 115179.

4. Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells. 

Brennan PJ, Saunders RE, Spanou M, Singleton SE, Serafini M, Sun L, Heger GP, Konopacka A, Beveridge RD, Taylor CC, DePaola P 4th, Gordon L, Bunally SB, Saudemont A, Benowitz AB, Martinez-Fleites C, Schmitt DL, Damoiseaux R, Queisser MA, An H, Deane CM, Hann MM, Brayshaw LL, Conway SJ^* 

ACS Chem. Biol. (2025) 20(11), 2827-2843

3. mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway. 

Yi SA, Sepic S, Schulman BA, Ordureau A, An H^*  

Molecular Cell (2024) 84, 1-19.

2. Identifying E3 ligase substrates with quantitative degradation proteomics. 

Jordan VN, Ordureau A, An H^* 

ChemBioChem. (2023) 24, e202300108.

1. Nanosensor-based monitoring of autophagy-associated lysosomal acidification in vivo. 

Kim M, Chen C, Yaari Z, Frederiksen R, Randall E, Wollowitz J, Cupo C, Wu X, Shah J, Worroll D, Lagenbacher RE, Goerzen D, Li YM, An H, Wang Y, Heller DA

Nat. Chem. Biol. (2023) 19, 1448-1457

Post-doc, PhD, and master trainings

16. Substitution of PINK1 Gly411 modulates substrate receptivity and turnover. 

Fiesel FC, Fričová D, Hayes CS, Coban MA, Hudec R, Bredenberg JM, Broadway BJ, Markham BN, Yan T, Boneski PK, Fiorino G, Watzlawik JO, Hou X, McCarty AM, Lewis-Tuffin LJ, Zhong J, Madden BJ, Ordureau A, An H, Puschmann A, Wszolek ZK, Ross OA, Harper JW, Caulfield TR, Springer W^* 

Autophagy (2023) 19, 1711-1732.

15. Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy. 

Ordureau A, Kraus F, Zhang J, An H, Park S, Ahfeldt T, Paulo JA, Harper JW^* 

Molecular Cell (2021) 81, 5082-5098

14. iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation. 

 Garshott DM, An H, Sundaramoorthy E, Leonard M, Vicary A, Harper JW, Bennett EJ^* 

Cell Reports (2021) 36, 109642.

13. Systematic quantitative analysis of ribosome inventory during nutrient stress. 

An H^#, Ordureau A^#, Koerner M, Paulo JA, Harper JW^*  

Nature (2020) 583, 303-309. # equal contribution

12. Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling. 

Ordureau A, Paulo JA, Zhang J, An H, Swatek KN, Cannon JR, Wan Q, Komander D, Harper JW^* 

Molecular Cell (2020) 77, 1124-1142.

11. Ribosome Abundance Control Via the Ubiquitin-Proteasome System and Autophagy. 

 An H, Harper, JW^* 

J. Mol. Biol. (2020) 432, 170-184, review article

10. TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress. 

An H, Ordureau A, Paulo JA, Shoemaker CJ, Denic V, Harper JW^* 

Molecular Cell (2019) 74, 891-908.

9. Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy. 

 An H, Harper JW^* 

Nat. Cell Biol. (2018) 20, 135-143.

8. Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies. 

Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA^* 

Sci. Rep. (2018) 8, 1405.

7. Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. 

Misra M, Kuhn M, Lobel M, An H, Statsyuk AV, Sotriffer C, Schindelin H^*  

Structure (2017) 25, 1120-1129.

6. Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis. 

An H, Statsyuk AV^* 

Chem. Comm. (2016) 52, 2477-2480.

5. An inhibitor of ubiquitin conjugation and aggresome formation. 

An H, Statsyuk AV^*  

Chem. Sci. (2015) 6, 5235-5245.

4. Crosstalk between kinases and Nedd4 family ubiquitin ligases. 

An H, Krist D, Statsyuk AV^* 

Mol. BioSyst. (2014) 10, 1643-1657, review article

3. Development of activity-based probes for ubiquitin and ubiquitin-like protein signaling pathways. 

An H, Statsyuk AV^*  

J. Am. Chem. Soc. (2011) 135 (45), 16948-16962.

2. Ratiometric analysis of zidovudine (ZDV) incorporation by reverse transcriptases or polymerases via bio-orthogonal click chemistry. 

Koh M, Park J, An H, Park SB.^*  

Chem. Commun. (2011) 47, 7614-6.

1. Diversity-oriented synthesis of privileged benzopyranyl heterocycles from s-cis-enones. 

An H, Eum SJ, Koh M, Lee SK, Park SB.^*  

J. Org. Chem. (2008) 73, 1752-61