Molecular Biology Program
The Iestyn Whitehouse Lab
The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on understanding basic mechanisms and use a combination of biochemical, molecular biological and genomics approaches. We like to develop new technology and are particularly interested in the development and application of single molecule technologies such as Nanopore sequencing and single molecule indexing strategies.
Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry. Meng X, Claussin C, Regan-Mochrie G, Whitehouse I, Zhao X.Genes Dev. 2023 Jan 26. doi: 10.1101/gad.350054.122.PMID: 36702483
Single-molecule mapping of replisome progression. Claussin C, Vazquez J, Whitehouse I.Mol Cell. 2022 Apr 7;82(7):1372-1382.e4. doi: 10.1016/j.molcel.2022.02.010. Epub 2022 Mar 2.PMID: 35240057
DNA replication through a chromatin environment. Bellush JM, Whitehouse I.Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731):20160287. doi: 10.1098/rstb.2016.0287.PMID: 28847824
DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNAreplication. Mattiroli F, Gu Y, Yadav T, Balsbaugh JL, Harris MR, Findlay ES, Liu Y, Radebaugh CA, Stargell LA, Ahn NG, Whitehouse I, Luger K.Elife. 2017 Mar 18;6:e22799. doi: 10.7554/eLife.22799.PMID: 28315523
Spatiotemporal coupling and decoupling of gene transcription with DNAreplication origins during embryogenesis in C. elegans. Pourkarimi E, Bellush JM, Whitehouse I.Elife. 2016 Dec 23;5:e21728. doi: 10.7554/eLife.21728.PMID: 28009254
Iestyn Whitehouse, PhD
Director of the Center for Epigenetics Research (CER)
- Molecular biologist Iestyn Whitehouse investigates chromatin structure and the function of ATP-dependent chromatin remodelling enzymes.
- PhD, The University of Dundee
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