Mara Sherman: Publications

The Mara Sherman Lab
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Mara Sherman: Publications

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Bhattacharyya S., Oon C., Diaz L., Sandborg H., Stempinski E.S., Saoi M., Morgan T.K., López C.S., Cross J.R., Sherman M.H. Autotaxin-lysolipid signaling suppresses a CCL11-eosinophil axis to promote pancreatic cancer progression. Nature Cancer, Jan 2024 doi: 10.1038/s43018-023-00703-y.

Sherman M.H.*, Beatty G.L.* Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance. Annual Review of Pathology: Mechanisms of Disease. Epub ahead of print. (*Co-corresponding author)

Sandborg H., Sherman M.H. (2022). NUFIP1+ stroma keeps PDAC fed. Nature Cancer. 3(8):909-910.

Abrego J.*, Sanford-Crane H.*, Oon C., Xiao X., Betts C.B., Sun D., Nagarajan S., Bhattacharyya S., Xia Z., Coussens L.M., Tontonoz P., Sherman M.H. (2022). A cancer cell-intrinsic GOT2-PPARd axis suppresses antitumor immunity. Cancer Discovery. 12(10):2414-2433. (*Co-first author)

  • Highlighted in In the Spotlight, Cancer Discovery, October 2022
  • Commentary by Nwosu Z.C. and Pasca di Magliano M., GOT2: An unexpected mediator of immunosuppression in pancreatic cancer, Cancer Discovery, October 2022
  • Commentary by Do B.T. and Vander Heiden M.G., GOT2 consider the tumor microenvironment, Trends in Cancer, September 2022

Sherman M.H. (2022). Finding method in the madness of pancreatic carcinogenesis. Cellular and Molecular Gastroenterology and Hepatology. 13(6):1845-1846.

Helms E.J., Berry M.W., Chaw R.C., DuFort C.C., Sun D., Onate M.K., Oon C., Bhattacharyya S., Sanford-Crane H., Horton W., Finan J.M., Sattler A., Makar R., Dawson D.W., Xia Z., Hingorani S.R., Sherman M.H. (2022). Mesenchymal lineage heterogeneity underlies non-redundant functions of pancreatic cancer-associated fibroblasts. Cancer Discovery. 12(2):484-501.

  • Highlighted in In the Spotlight, Cancer Discovery, February 2022
  • Commentary by Cukierman E., The Few yet Fabp4ulous Pancreatic Stellate Cells Give Rise to Protumoral CAFs, Cancer Discovery, February 2022

Sherman M.H. (2021). Lipid carriers in cancer: Context matters. Cancer Research. 81(16):4186-4187.

Sherman M.H. (2021). A pre-synaptic protein is a net gain for pancreatic tumor progression. Cancer Discovery. 11(2):230-232.

Vickmen R.E., Faget D.V., Beachy P., Beebe D., Bhowmick N.A., Cukierman E., Deng W.M., Granneman J.G., Hildesheim J., Kalluri R., Lau K.S., Lengyel E., Lundeberg J., Moscat J., Nelson P.S., Pietras K., Politi K., Puré E., Scherz-Shouval R., Sherman M.H., Tuveson D., Weereratna A.T., White R.M., Wong M.H., Woodhouse E.C., Zheng Y., Hayward S.W., Stewart S.A. (2020). Deconstructing tumor heterogeneity: the stromal perspective. Oncotarget. 11(40):3621-3632.

Zhu Z., Achreja A., Meurs N., Animasahun O., Owen S., Mittal A., Parikh P., Lo T., Franco-Barraza J., Shi J., Gunchick V., Sherman M.H., Cukierman E., Pickering A.M., Maitra A., Sahai V., Morgan M.A., Nagrath S., Lawrence T.S., Nagrath D. (2020). Tumor-reprogrammed stromal BCAT1 fuels branched chain ketoacid dependency in stromal-rich PDAC tumors. Nature Metabolism. 2: 775-792.

Bhattacharyya S., Oon C., Kothari A., Horton W., Link J., Sears R.C., Sherman M.H. (2020). Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer. Journal of Experimental Medicine. 217(8):e20191805.

Sahai E., Astsaturov I., Cukierman E., DeNardo D.G., Egeblad M., Evans R.M., Fearon D., Greten F.R., Hingorani S.R., Hunter T., Hynes R.O., Jain R.K., Janowitz T., Jorgensen C., Kimmelman A.C., Kolonin M.G., Maki R.G., Powers R.S., Puré E., Ramirez D.C., Scherz-Shouval R., Sherman M.H., Stewart S., Tlsty T.D., Tuveson D.A., Watt F.M., Weaver V., Weeraratna A.T., Werb Z. (2020). A framework for advancing our understanding of cancer-associated fibroblasts. Nature Reviews Cancer. 20:174-186.

Helms E.*, Onate M.K.*, Sherman M.H. (2020). Fibroblast heterogeneity in the pancreatic tumor microenvironment. Cancer Discovery. 10(5):648-656. (*Co-first author)

Sanford-Crane H.*, Abrego J.*, Sherman M.H. (2019). Fibroblasts as modulators of local and systemic cancer metabolism. Cancers (Basel). 11(5):619-633. (*Co-first author)

Auciello F.R.#, Bulusu V.#, Oon C., Tait-Mulder J., Berry M., Bhattacharyya S., Tumanov S., Allen-Petersen B.L., Link J., Kendsersky N.D., Vringer E., Schug M., Novo D., Hwang R.F., Evans R.M., Nixon C., Dorrell C., Morton J.P., Norman J.C., Sears R.C., Kamphorst J.J.*, Sherman M.H.*. (2019). A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. Cancer Discovery. 9(5):617-627. (#Co-first author, *Co-corresponding author)

  • Highlighted in In the Spotlight, Cancer Discovery, May 2019
  • Commentary by Biffi G. and Tuveson D.A., A FATal combination: Fibroblast-derived lipids and cancer-derived autotaxin promote pancreatic cancer growth, Cancer Discovery, May 2019

Sherman, M.H. (2018). Stellate cells in tissue repair, inflammation, and cancer.  Annual Review of Cell and Developmental Biology. 34:333-355.

Wei Z., Yoshihara E., He N., Hah N., Fan W., Pinto A.F.M., Huddy T., Wang Y., Ross B., Estepa G., Dai Y., Ding N., Sherman M.H., Fang S., Zhao X., Liddle C., Atkins A.R., Yu R.T., Downes M., Evans R.M. (2018). Vitamin D switches BAF complexes to protect b cells. Cell. 173(5):1135-1149.

Sherman M.H., Yu R.T., Tseng T.W., Sousa C.M., Liu S., Truitt M.L., He N., Ding N., Liddle C., Atkins A.R., Leblanc M., Collisson E.A., Asara J.M., Kimmelman A.C., Downes M., Evans R.M. (2017). Stromal cues regulate the pancreatic cancer epigenome and metabolome.  Proceedings of the National Academy of Sciences. 114(5):1129-1134.

Sousa C.M., Biancur D.E., Wang X., Halbrook C.J., Sherman M.H., Zhang L., Kremer D., Hwang R.F., Witkiewicz A.K., Ying H., Asara J.M., Evans R.M., Cantley L.C., Lyssiotis C.A., Kimmelman A.C. (2016). Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 536(7617):479-83.

Hah N.*, Sherman M.H.*, Yu R.T., Downes M., Evans R.M. (2016). Targeting transcriptional and epigenetic reprogramming in stromal cells in fibrosis and cancer.  Cold Spring Harb Symp Quant Biol. 80:249-255. (*Co-first author)

Ding N., Hah N., Yu R.T., Sherman M.H., Benner C., Leblanc M., He M., Liddle C., Downes M., Evans R.M. (2015). BRD4 is a novel therapeutic target for liver fibrosis. Proceedings of the National Academy of Sciences. 112(51):15713-8.

Arensman M.D., Nguyen P., Kershaw K.M., Lay A.R., Ostertag-Hill C.A., Sherman M.H., Downes M., Liddle C., Evans R.M., Dawson D.W.  (2015).  Calcipotriol targets LRP6 to inhibit Wnt signaling in pancreatic cancer.  Molecular Cancer Research.  13(11):1509-19.

Sherman M.H., Yu R.T., Atkins A.R., Ding N., Collisson E.A., Connor F., Van Dyke T., Kozlov S., Martin P., Engle D.D., Tiriac H., Tseng T.W., Dawson D.W., Donahue T.R., Masamune A., Shimosegawa T., Apte M.V., Wilson J.S., Ng B., Lau S.L., Gunton J.E., Wahl G.M., Hunter T., Drebin J.A., O’Dwyer P.J., Liddle C., Tuveson D.A., Downes M., Evans R.M. (2014).  Vitamin D Receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy.  Cell.  159(1):80-93.  

  • Highlighted in Research Highlights, Nature Reviews Cancer, October 2014
  • Commentary by Rowley D.R., Reprogramming the tumor stroma: A new paradigm, Cancer Cell, October 2014
  • Commentary by Froeling F.E. and Kocher H.M., Homeostatic restoration of desmoplastic stroma rather than its ablation slows pancreatic cancer progression, Gastroenterology, April 2015

Ding N., Yu R.T., Subramaniam N., Sherman M.H., Wilson C., Rao R., Leblanc M., Coulter S., He M., Scott C., Lau S.L., Atkins A.R., Barish G.D., Gunton J.E., Liddle C., Downes M., Evans R.M.  (2013). A Vitamin D Receptor/SMAD genomic circuit gates hepatic fibrotic response.  Cell. 153(3):601-13.

Subramaniam N., Sherman M.H., Rao R., Wilson C., Coulter S., Atkins A.R., Evans R.M., Liddle C., Downes M. (2012). Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling.  Cancer Prevention Research.  5(4):553-61.

Sherman M.H., Downes M., Evans R.M.  (2012).  Nuclear receptors as modulators of the tumor microenvironment.  Cancer Prevention Research.  5(1):3-10.

Sherman M.H., Bassing C.H., Teitell M.A.  (2011).  Regulation of cell differentiation by the DNA damage response.  Trends in Cell Biology.  21(5):312-9.

Sherman M.H., Kuraishy A.I., Deshpande C., Hong J.S., Cacalano N.A., Gatti R.A., Manis J.P., Damore M.A., Pellegrini M., Teitell M.A.  (2010).  AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.  Molecular Cell. 39(6):873-85.

Chen S., Sherman M.H., Hertlein E., Johnson A.J., Teitell M.A., Byrd J.C., Plass C.  (2009).  Epigenetic alterations in a murine model for chronic lymphocytic leukemia.  Cell Cycle.  8(22):3663-7.

Balatoni C.E., Dawson D.W., Suh J., Sherman M.H., Sanders G., Hong J.S., Frank M.J., Malone C.S., Said J., Teitell M.A.  (2009).  Epigenetic silencing of Stk39 in B-cell lymphoma inhibits apoptosis from genotoxic stress.  American Journal of Pathology.  175(4):1653-61.

Chen S., Raval A., Johnson A., Hertlein E., Liu T., Jin V.X., Sherman M.H., Liu S., Dawson D.W., Williams K.E., Lanasa M., Liyanarachchi S., Lin T.S., Marcucci G., Pekarsky Y., Davuluri R., Croce C.M., Guttridge D.C., Teitell M.A., Byrd J.C., Plass C.  (2009).  Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia.  Proceedings of the National Academy of Sciences.  106(32):13433-8. 

Kuraishy A.I.., French S.W., Sherman M., Herling M., Jones D., Wall R., Teitell M.A.  (2007).  TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation.  Proceedings of the National Academy of Sciences.  104(24):10175-80.

Morley S., Wagner J., Kauppinen K., Sherman M., Manor D.  (2007).  Requirement for Akt-mediated survival in cell transformation by the dbl oncogene.  Cellular Signaling.  19(1):211-8.