Hyein Cho, PhD

Sr. Computational Biologist

Hyein Cho, PhD

Sr. Computational Biologist
Hyein Cho

Sr. Computational Biologist

Start Year



PhD, Weill Cornell Graduate School of Medical Sciences

Hyein (she/they) is a computational biologist serving in an integral role within the Huangfu lab. She completed her Ph.D. at Weill Cornell Medicine in 2019, specializing in systems biology. 

During her doctoral studies, under the guidance of Dr. Christina Leslie, Hyein focused on sequence-based motif analysis of chromatin accessibility and binding patterns of pioneer transcription factors, particularly in the context of stem cell development. 

Currently, Hyein contributes her expertise to the MSK MorPhiC (Molecular Phenotypes of Null Alleles in Cells) grant. Her responsibilities encompass the management and analysis of large-scale perturbation and demultiplexing experiments. 

Beyond her scientific contributions, Dr. Cho continues to pave the way as a pioneer, openly transgender scientist. In her leisure time, she finds joy in activities such as cycling and endurance running. Additionally, she possesses a strong passion for electronic music, coffee, and taking nighttime strolls.


CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction. Yang D, Cho H, Tayyebi Z, Shukla A, Luo R, Dixon G, Ursu V, Stransky S, Tremmel DM, Sackett SD, Koche R, Kaplan SJ, Li QV, Park J, Zhu Z, Rosen BP, Pulecio J, Shi ZD, Bram Y, Schwartz RE, Odorico JS, Sidoli S, Wright CV, Leslie CS, Huangfu D. Nat Cell Biol. 2022 Jul;24(7):1064-1076. doi: 10.1038/s41556-022-00946-4. [PMID: 35787684]

CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters. Ortabozkoyun H, Huang PY, Cho H, Narendra V, LeRoy G, Gonzalez-Buendia E, Skok JA, Tsirigos A, Mazzoni EO, Reinberg D.Nat Genet. 2022 Feb;54(2):202-212. doi: 10.1038/s41588-021-01008-5. [PMID: 35145304]

Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis. Duan S, Moro L, Qu R, Simoneschi D, Cho H, Jiang S, Zhao H, Chang Q, de Stanchina E, Arbini AA, Pagano M. Cell Rep. 2021 Oct 19;37(3):109870. doi: 10.1016/j.celrep.2021.109870. [PMID: 34686346] 

FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation. Lee K, Cho H, Rickert RW, Li QV, Pulecio J, Leslie CS, Huangfu D. Cell Rep. 2019 Jul 9;28(2):382-393.e7. doi: 10.1016/j.celrep.2019.06.034. [PMID: 31291575] 

 FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. Adams EJ, Karthaus WR, Hoover E, Liu D, Gruet A, Zhang Z, Cho H, DiLoreto R, Chhangawala S, Liu Y, Watson PA, Davicioni E, Sboner A, Barbieri CE, Bose R, Leslie CS, Sawyers CL. Nature. 2019 Jul;571(7765):408-412. doi: 10.1038/s41586-019-1318-9. [PMID: 31243370]

IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation. Park SM, Cho H, Thornton AM, Barlowe TS, Chou T, Chhangawala S, Fairchild L, Taggart J, Chow A, Schurer A, Gruet A, Witkin MD, Kim JH, Shevach EM, Krivtsov A, Armstrong SA, Leslie C, Kharas MG. Cell Stem Cell. 2019 Jan 3;24(1):153-165.e7. doi: 10.1016/j.stem.2018.10.016. [PMID: 30472158]

Memory of Inflammation in Regulatory T Cells. van der Veeken J, Gonzalez AJ, Cho H, Arvey A, Hemmers S, Leslie CS, Rudensky AY. Cell. 2016 Aug 11;166(4):977-990. doi: 10.1016/j.cell.2016.07.006.[PMID: 27499023]