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Jacob A. Boyer, PhD

Ludwig Princeton Scholar in Cancer Metabolism at Princeton University, Princeton, NJ

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Jacob A. Boyer

Email

[email protected]

Dissertation

Estrogen Receptor Alpha Translation, Mechanistic Insights and Therapeutic Implications

Mentor

Neal Rosen, MD, PhD

Start Year

2014

End Year

2022

Education

BS, Pennsylvania State University

Research Focus

Adaptation of cells to mTOR inhibition and development of mTORC1 selective inhibitors.

Fellowships

GSK Grayer Fellowship (2016-2017)

Geoffrey Beene Graduate Student Fellowship (2015-2016)

Publications

Lee BJ, Boyer JA, Burnett GL, Thottumkara AP, Tibrewal N, Wilson SL, Hsieh T, Marquez A, Lorenzana EG, Evans JW, Hulea L, Kiss G, Liu H, Lee D, Larsson O, McLaughlan S, Topisirovic I, Wang Z, Wang Z, Zhao Y, Wildes D, Aggen JB, Singh M, Gill AL, Smith JAM, Rosen N. (2021) Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth. Nat Chem Biol. Online ahead of print.

Mukherjee R, Vanaja KG, Boyer JA, Gadal S, Solomon H, Chandarlapaty S, Levchenko A, Rosen N. (2021) Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis. Mol Cell 84, 708-723.

Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, Peerschke E, Friedman SL, Ponomarev V, Piersigilli A, Sadelain M, Lowe SW; (2020) Senolytic CAR T Cells Reverse Senescence-Associated Pathologies Nature 583. 127-132.

Smith KJ, Murray IA, Boyer JA, Perdew GH. (2017) Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice. Toxicology, 394, 27-34. PMCID: PMC5756104

Smith KJ, Boyer JA, Muku GE, Murray IA, Gowda K, Desai D, Amin SG, Glick AB, Perdew GH. (2017) Ah receptor activation potentiates neutrophil chemoattractant (C-X-C motif) ligand 5 expression in keratinocytes and skin. Toxicol Sci., 160, 83-94. PMCID: PMC5837612

Lahoti TS, Boyer JA, Kusnadi A, Muku GE, Murray IA, Perdew GH. (2015) Aryl Hydrocarbon Receptor Activation Synergistically Induces Lipopolysaccharide-Mediated Expression of Proinflammatory Chemokine (c-c motif) Ligand 20. Toxicol Sci., 148, 229-40. PMCID: PMC4731409.