The Molecular Pharmacology Program at SKI serves as a conduit for advancing basic biological discoveries into the preclinical and clinical settings. Our research spans the full spectrum of pharmacological interests, from small molecule drug development, drug sensitivity and resistance, molecular biology of drug action, cell signaling, drug delivery, transcriptional regulation, stem cells, and neuropharmacology to nanoparticle design and applications, smart drugs, imaging agents, and antibody, cell, vaccine, and cytokine therapies. Discoveries in the laboratory are often tested in clinic at Memorial Hospital, where many of our faculty also hold appointments.

Our multidisciplinary collaborations across the MSK community as well as with nearby Rockefeller University and Weill Cornell Medicine place us in a unique position to accelerate the development of novel therapies for patients.

Molecular Pharmacology Chair David Scheinberg

Molecular Pharmacology Chair David Scheinberg

 

Our Faculty

  • David A. Scheinberg, MD, PhD
    Chair, Molecular Pharmacology Program
    Molecular Pharmacology Program Chair David Scheinberg focuses on the discovery and development of novel, specific immunotherapeutic agents and targeted nanodevices for cancer therapy.
  • Colin Begg, PhD
    Epidemiologist Colin Begg focuses on statistical methods for cancer epidemiology, health services research, and clinical trials.
  • Ronald G. Blasberg, MD
    Physician-scientist Ronald Blasberg focuses on the development of noninvasive imaging paradigms in living organisms using radionuclide and optical reporter systems.
  • Bayard Clarkson, MD
    Chemical biologist Bayard Clarkson focuses on the development of targeted therapies aimed at cancer stem cells.
  • Zvi Fuks, MD
    Zvi Fuks studies mechanisms of radiation-induced damage and the clinical basis of radiation resistance.
  • Karuna Ganesh, MD, PhD
    Physician-scientist Karuna Ganesh studies stem cell plasticity in metastasis, therapy resistance and tissue regeneration.
  • Jan Grimm, MD, PhD
    Radiologist and Nuclear Medicine physician Jan Grimm develops novel approaches for improved diagnosis, monitoring and therapy of prostate and other cancers.
  • Daniel A. Heller, PhD
    Chemist Daniel Heller focuses on biomaterials and nanoscale engineering for molecular sensors and targeted therapeutics.
  • Hedvig Hricak, MD, PhD
    Radiologist Hedvig Hricak researches methodologies of molecular imaging of prostate and gynecologic tumors.
  • Alex Kentsis, MD, PhD
    Cancer biologist and pediatric oncologist Alex Kentsis leads research in the functional proteomics and molecular pharmacology of refractory childhood cancers.
  • Michael G. Kharas, PhD
    Cancer biologist Michael Kharas studies RNA regulators of self-renewal in both normal and leukemic hematopoiesis.
  • Richard N. Kolesnick, MD
    Physician-scientist Richard Kolesnick studies the role of ceramide signaling in radiation-induced vascular dysfunction and tumor regression.
  • Steven M. Larson, MD
    Nuclear medicine physician Steven Larson focuses on molecular imaging in animals and humans using high-resolution diagnostic instruments, such as positron emission tomography, and single photon emission tomography.
  • Neal Rosen, MD, PhD
    Pharmacologist Neal Rosen focuses on understanding biochemical mechanisms underlying phenotypes caused by tyrosine kinase activation in epithelial tumors and developing new therapeutic strategies.

Joint Appointees

  • Michelle S. Bradbury, MD, PhD
    Clinician-scientist Michelle Bradbury develops translational, tumor-targeting, PET-optical silica nanoparticle probes for diagnostics, drug delivery, and sensing.
  • Renier J. Brentjens, MD, PhD
    Physician-scientist Renier Brentjens develops novel immunotherapies for leukemias and lymphomas.
  • Kayvan R. Keshari, PhD
    Biochemist and imaging specialist Kayvan Keshari explores changes in cancer metabolism to develop advanced imaging techniques and cancer targets.
  • Jason A. Koutcher, MD, PhD
    Physician-scientist Jason Koutcher studies applications of magnetic resonance spectroscopy and imaging to enhance the therapeutic gain of different antineoplastic modalities.
  • Jason S. Lewis, PhD
    Radiochemist Jason Lewis develops molecular imaging agents for the imaging and therapy of cancer.
  • Vladimir Ponomarev, MD, PhD
    Physician-scientist Vladimir Ponomarev focuses on developing reporter genetic systems for specific applications such as sequential in vivo imaging studies in cancer biology, cancer immunotherapy, and radiation sciences.
  • Charles M. Rudin, MD, PhD
    Physician-scientist Charles Rudin focuses on the development and testing of novel therapeutic approaches to lung cancer in preclinical models.

Collaborations & Resources

SKI offers a wide array of core facilities and other technologies, as well as significant opportunity for collaboration across MSK. Members of the Molecular Pharmacology Program derive particular benefit from close ties to the following:

Education & Training

The Molecular Pharmacology Program regularly hosts postdoctoral fellows and students from the following graduate programs:

Latest News

View latest research news from the Sloan Kettering Institute.

View all news
Seminars & Events

View events and symposia sponsored by the Molecular Pharmacology Program.

View all upcoming events