Mohamed Gatie, PhD

Postdoctoral Research Fellow

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Lab Phone

212-639-8215

Lab Fax

646-422-2355

Education
2015-2021:  PhD, Developmental Biology, Western University, Ontario, Canada

2010-2014:  BS, Biology, Western University, Ontario, Canada

Research Interests
How cells differentiate and acquire specific identities, organize in an orchestrated manner to generate an anatomical, fully functional organ remains an elusive mystery in developmental biology. My studies will focus on understanding the mechanisms that govern the formation of endodermal organs by integrating high-resolution imaging with single-cell genomic technologies, coupled with precision mouse genetics approaches. My project will enhance our understanding of normal foregut development, a cornerstone for improving the understanding and treatment of congenital birth defects and chronic diseases associated with this tissue and its organ derivatives. 

Publications

Gatie MI, Cooper, T. T., Khazaee, R., Lajoie, G. A. and Kelly, G. M (2021). Lactate accelerates mouse ES cell differentiation towards the XEN lineage. Stem Cells.

Sun Q, Gatie MI, Kelly GM (2019). Serum-dependent and -independent regulation of PARP2. Biochem Cell Biol. 97(5):600-611. doi: 10.1139/bcb-2018-0345. Epub 2019 Mar 17. PMID: 30880404.

Gatie MI, Assabgui AR, Kelly GM (2018). The Zen of XEN: insight into differentiation, metabolism and genomic integrity. Cell Death Dis. 9(11):1075. doi: 10.1038/s41419-018-1120-x. PMID: 30349040; PMCID: PMC6197270.

Gatie MI, Kelly GM (2018). Metabolic profile and differentiation potential of extraembryonic endoderm-like cells. Cell Death Discov. 4:42. doi: 10.1038/s41420-018-0102-1. Erratum in: Cell Death Discov. 2019 Jul 10;5:116. PMID: 30302276; PMCID: PMC6158286.

Deol GSJ, Cuthbert TN, Gatie MI, Spice DM, Hilton LR, Kelly GM (2017). Wnt and Hedgehog Signaling Regulate the Differentiation of F9 Cells into Extraembryonic Endoderm. Front Cell Dev Biol. 5:93. doi: 10.3389/fcell.2017.00093. PMID: 29119099; PMCID: PMC5660979.

Kelly GM, Gatie MI (2017). Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells. Stem Cells Int. 2017:3684178. doi: 10.1155/2017/3684178. Epub 2017 Mar 8. PMID: 28373885; PMCID: PMC5360977.

Dickson BJ, Gatie MI, Spice DM, Kelly GM (2017). NOX1 and NOX4 are required for the differentiation of mouse F9 cells into extraembryonic endoderm. PLoS One. 12(2):e0170812. doi: 10.1371/journal.pone.0170812. PMID: 28152080; PMCID: PMC5289483.

Golenia G, Gatie MI, Kelly GM (2017). Frizzled gene expression and negative regulation of canonical WNT-β-catenin signaling in mouse F9 teratocarcinoma cells. Biochem Cell Biol. 95(2):251-262. doi: 10.1139/bcb-2016-0150. Epub 2016 Sep 13. PMID: 28177772.