Developmental Biology Program
The Anna-Katerina Hadjantonakis Lab
Cancer is a condition promoted by cells undergoing an identity crisis. An understanding of how cells control their identity (cell fate specification), and how they organize themselves into normal tissues (morphogenesis) provides the blueprint for the fundamental biological processes that become deregulated in cancer.
The Hadjantonakis laboratory uses high-resolution quantitative methods to investigate the mechanisms underlying stem cell specification, cellular differentiation, tissue organization and growth. They use the mammalian embryo as a platform, and the mouse as a primary model system. They also exploit in vitro cultured stem cells, including pluripotent stem cells, for their studies.
Morgani SM, Su J, Nichols J, Massagué J, Hadjantonakis AK The transcription factor Rreb1 regulates epithelial architecture, invasiveness and vasculogenesis in early mouse embryos Elife. 2021 Apr 30;10:e64811. doi: 10.7554/eLife.64811. Epub ahead of print. PMID: 33929320
Simon CS, Rahman S, Raina D, Schröter C, Hadjantonakis AK. Live Visualization of ERK Activity in the Mouse Blastocyst Reveals Lineage-Specific Signaling Dynamics. Dev Cell. 2020 Oct 16; S1534-5807(20)30762-0. doi: 10.1016/j.devcel.2020.09.030
Saiz N, Mora-Bitria L, Rahman S, George H, Herder J, Garcia-Ojalvo J, Hadjantonakis AK. Growth factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development. Elife. 2020 Jul 28;9:e56079. doi: 10.7554/eLife.56079.
Nowotschin S, Setty M, Kuo YY, Liu V, Garg V, Sharma R, Simon CS, Saiz N, Gardner R, Boutet SC, Church DM, Hoodless PA, Hadjantonakis AK, Pe’er D. The emergent landscape of the mouse gut endoderm at single-cell resolution. Nature. 2019 May;569(7756):361-367. doi: 10.1038/s41586-019-1127-1.
Anna-Katerina Hadjantonakis, PhD
Chair, Developmental Biology Program, SKI
- The Hadjantonakis laboratory studies pluripotency, cell lineage commitment, tissue patterning, and morphogenesis in mammalian embryos and in vitro stem cell models.
- PhD, Imperial College (London)
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Anna-Katerina Hadjantonakis discloses the following relationships and financial interests:
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