Vidur Garg

Graduate Student

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Vidur Garg

Education

2013 – present: Graduate Student, Biochemistry, Cell and Molecular Biology Program, Weill Cornell Graduate School of Medical Sciences (lab of Kat Hadjantonakis); 2010 – 2012: BA, Hunter College of the City University of New York, New York, NY; 2008 – 2009: AS, Henry Ford Community College, Dearborn, MI; 2007 – 2008: Hunter College of the City University of New York, New York, NY

Research Interests
For my graduate studies I am interested in understanding the genetic factors that regulate cell lineage specification and cell identity in the context of mammalian development. Following the fertilization of an oocyte, this single cell undergoes several rounds of divisions to form an embryo (also called a blastocyst) that implants into the mother’s uterus. Along the way these cells decide between one fate or another. One of these fate decisions is that of the epiblast lineage – the progenitor population of the entire embryo and adult mammal. Thus, it is by definition a pluripotent cell population.

I utilize a combination of quantitative high-resolution imaging, high throughput image analysis, in vivo genetic models, including fluorescent reporter lines, and in vitro stem cells to identify factors that are involved in lineage decisions and the establishment of pluripotency. Understanding how these factors regulate cell identity and the establishment of pluripotency holds far reaching potential for stem cell biology and regenerative medicine.

My previous work deciphering the function of microRNAs in mouse neocortex development and neural stem cell differentiation (Dr. Tao Sun’s lab, Weill Cornell Medical College), and alternative 3’UTRs in oncogenesis (Dr. Christine Mayr’s lab, Sloan Kettering Institute) has provided a basis for my interest in genetic regulation of cell identities. I am able to extend my previous understanding of gene regulation to the mechanisms regulating key early developmental events in the Hadjantonakis lab.

Publications

Nowotschin S, Setty M, Kuo YY, Lui V, Garg V, Sharma R, Simon CS, Saiz N, Gardner R, Boutet S, Church DM, Hoodless PA, Hadjantonakis AK, Pe’er D. (2019) The emergent landscape of the mouse gut endoderm at single-cell resolutionNature. 569(7756):361-367. doi:10.1038/s41586-019-1127-1. PMID: 30959515 PMCID: PMC6724221

Nowotschin S, Garg V, Piliszek A, Hadjantonakis AK. (2019) Ex utero culture and live imaging of mouse embryos. Methods in Molecular Biology.1920:163-182. doi:10.1007/978-1-4939-9009-2_11. PMID: 21805267 PMCID: PMC3298811

Morgani, S.M. , Saiz, N., Garg, V., Raina, D., Simon, C.S., Kang, M., Arias, A.M., Nichols, J., Schroter, C, Hadjantonakis, A.-K. (2018) A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice. Dev. Biol. 441, 104–126. doi:10.1016/j.ydbio.2018.06.017. PMID: 29964027 PMCID: PMC6455974

Kang, M., Garg, V. & Hadjantonakis, A.-K. (2017) Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2. Dev. Cell 41, 496-510.e5. doi:10.1016/j.devcel.2017.05.003. PMID: 28552559 PMCID: PMC5530874

Liu, Y., Pelham-Webb, B., Di Gimmartino, D.C., Li, J., Kim, D., Kita, K., Saiz, N., Garg, V., Doane, A., Giannakakou, P., Hadjantonakis, A.-K., Elemento, O., Apostolou, E. (2017) Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells. Cell Rep. 19, 1283–1293. doi: 10.1016/j.celrep.2017.04.067. PMID: 28514649 PMCID: PMC5495017

Garg, V., Morgani, S. & Hadjantonakis, A.-K. (2016) Capturing Identity and Fate Ex Vivo. Current Topics in Developmental Biology. 120, 361–400. doi: 10.1016/bs.ctdb.2016.04.007. PMID: 27475857