Chemical Biology Program

The Minkui Luo Lab

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Research

Minkui Luo, PhD
Minkui Luo, PhD

The projects of this laboratory aim to leverage cutting-edge approaches in combination of chemistry and biology to annotate, perturb and manipulate essential functions of protein methyltransferases implicated in epigenetic biology and cancer. The Luo laboratory is also interested in designing and synthesizing inhibitors as potential anti-cancer drugs with the emphasis of their distinct modes of action and wise uses in relevant disease contexts. Researchers in the field of chemistry, biochemistry and biology work in a highly collaborative manner to synthesize novel chemical reagents, elucidate disease-causing mechanisms at molecular levels, and develop potential treatments for human diseases.

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The Minkui Luo Lab

Featured News

In the Lab
Two clusters of colored blobs with a diagram in the middle
Computational “Hive Mind” Helps Scientists Solve an Enzyme’s Cryptic Movements

Q&A
Epigenetics
Setting Cancer Cells on the Right Path: A New Leukemia Drug Shows Growing Promise

Publications

Joshua A. Linscott, Kanishk Kapilashrami, Zhen Wang, Chamara Senevirathne, Ian R. Bothwell, Gil Blum, Minkui Luo, “Kinetic Isotope Effects Reveal Early SN2 Transition State of SET8-catalyzed Protein Lysine Methylation”, Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E8369.

Zhang L, Tran NT, Su H, Wang R, Lu Y, Tang H, Aoyagi S, Guo A, Khodadadi-Jamayran A, Zhou D, Qian K, Hricik T, Côté J, Han X, Zhou W, Laha S, Abdel-Wahab O, Levine RL, Raffel G, Liu Y, Chen D, Li H, Townes T, Wang H, Deng H, Zheng YG, Leslie C, Luo M, Zhao X. “Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing”, Elife, 2015, e07938

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People

Minkui Luo, PhD

Minkui Luo, PhD

  • Chemical Biologist Minkui Luo develops cutting-edge tools, technologies and concepts to annotate functions of protein-posttranslational modifications and designs inhibitors for cancer therapies.
  • BS, Fudan University
  • PhD, Princeton University
luom@mskcc.org
Email Address
646-888-3066
Office Phone
Download CV
PDF File

Members

Minkui Luo

Lab Head

Junyi Wang, MS
Junyi Wang

Research Technician

Nawei Zhang, MD
Nawei Zhang

Senior Research Scientist

Ryan Blawski, BS
Ryan Blawski

Graduate Student

Ming Jiang

Graduate Student

Deyao Li

Research Fellow

Zhizhong Li

Research Assistant

Laura Minaya
Laura Vidal

Administrative Assistant

Ke Wang
Ke Wang

Senior Research Scientist

Nicole Weiss
Nicole Weiss

Graduate Student

Yu Zong

Research Fellow

Lab Alumni
Candice Thompson

Administration Assistant

Gil Blum

Graduate Student

Ian Bothwell

Graduate Student

Han Guo

Graduate Student

Liudmila Dzhekieva

Postdoctoral Fellow

Chamara Senevirathne, PhD
Chamara Senevirathne

Postdoctoral Fellow

Xiaochuan Cai, PhD
Xiaochuan Cai

Postdoctoral Fellow

Kanishk Kapilashrami

Postdoctoral Fellow

Li Yang

Visiting Professor

Fabio Pittella, PhD
Fabio Pittella

Visiting Investigator

Shi Chen, BS
Shi Chen

Graduate Student

Cynthia Quintero
Cynthia Quintero

Joint Graduate Student with the Gudas Lab

Wei Tan

Joint Postdoctoral Fellow with the Zhao Lab

Elizabeth Isaac
Elizabeth Isaac

Graduate Student

Michael Langberg, PhD
Michael Langberg

Research Fellow

Lihui Wang

Visiting Investigator

Yongxia Zhu
Yongxia Zhu

Graduate Research Student

Lab Affilations

Achievements

  • Eli Lilly Award in Biological Chemistry, American Chemical Society (2015)
  • Clinical & Translational Science Center Novel Award, Weill Cornell Medical College (2014)
  • Basil O'Connor Starter Scholar, March of Dimes Birth Defects Foundation (2011)
  • Director’s New Innovator Award, National Institutes of Health (2010)
  • Alfred W. Bressler Scholar, Alfred W. Bressler Scholars Endowment Fund (2010)
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  • V Scholar Award, V Foundation for Cancer Research (2009)
  • Outstanding Postdoctoral Research Prize, Albert Einstein College of Medicine (2007)

Lab News & Events

Upcoming event

Academic Drug Discovery and Chemical Biology of Chromatin Regulation

This seminar will be conducted by Zoom Webinar.

Open Positions

Career Opportunities

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Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Minkui Luo discloses the following relationships and financial interests:

  • Doris Duke Charitable Foundation
    Provision of Services
  • SINO-US Chemistry Professors Conference
    Provision of Services (uncompensated)
  • ShanghaiTech University
    Provision of Services (uncompensated)
  • Westlake University
    Provision of Services
  • Zhejiang University
    Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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