Chemical Biology Program
The Minkui Luo Lab
Research

The projects of this laboratory aim to leverage cutting-edge approaches in combination of chemistry and biology to annotate, perturb and manipulate essential functions of protein methyltransferases implicated in epigenetic biology and cancer. The Luo laboratory is also interested in designing and synthesizing inhibitors as potential anti-cancer drugs with the emphasis of their distinct modes of action and wise uses in relevant disease contexts. Researchers in the field of chemistry, biochemistry and biology work in a highly collaborative manner to synthesize novel chemical reagents, elucidate disease-causing mechanisms at molecular levels, and develop potential treatments for human diseases.

Featured News
Publications
Joshua A. Linscott, Kanishk Kapilashrami, Zhen Wang, Chamara Senevirathne, Ian R. Bothwell, Gil Blum, Minkui Luo, “Kinetic Isotope Effects Reveal Early SN2 Transition State of SET8-catalyzed Protein Lysine Methylation”, Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E8369.
Zhang L, Tran NT, Su H, Wang R, Lu Y, Tang H, Aoyagi S, Guo A, Khodadadi-Jamayran A, Zhou D, Qian K, Hricik T, Côté J, Han X, Zhou W, Laha S, Abdel-Wahab O, Levine RL, Raffel G, Liu Y, Chen D, Li H, Townes T, Wang H, Deng H, Zheng YG, Leslie C, Luo M, Zhao X. “Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing”, Elife, 2015, e07938
People

Minkui Luo, PhD
- Chemical Biologist Minkui Luo develops cutting-edge tools, technologies and concepts to annotate functions of protein-posttranslational modifications and designs inhibitors for cancer therapies.
- BS, Fudan University
- PhD, Princeton University
- luom@mskcc.org
- Email Address
- 646-888-3066
- Office Phone
- Download CV
- PDF File
Members

Lab Head

Research Technician

Senior Research Scientist

Graduate Student

Graduate Student
Research Fellow
Research Assistant

Administrative Assistant

Senior Research Scientist

Graduate Student
Research Fellow
Lab Alumni
Administration Assistant
Graduate Student
Graduate Student
Graduate Student
Postdoctoral Fellow

Postdoctoral Fellow

Postdoctoral Fellow
Postdoctoral Fellow
Visiting Professor

Visiting Investigator

Graduate Student

Joint Graduate Student with the Gudas Lab
Joint Postdoctoral Fellow with the Zhao Lab

Graduate Student

Research Fellow
Visiting Investigator

Graduate Research Student
Lab Affilations
Achievements
- Eli Lilly Award in Biological Chemistry, American Chemical Society (2015)
- Clinical & Translational Science Center Novel Award, Weill Cornell Medical College (2014)
- Basil O'Connor Starter Scholar, March of Dimes Birth Defects Foundation (2011)
- Director’s New Innovator Award, National Institutes of Health (2010)
- Alfred W. Bressler Scholar, Alfred W. Bressler Scholars Endowment Fund (2010)
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- V Scholar Award, V Foundation for Cancer Research (2009)
- Outstanding Postdoctoral Research Prize, Albert Einstein College of Medicine (2007)
Lab News & Events
Upcoming event
Academic Drug Discovery and Chemical Biology of Chromatin Regulation
This seminar will be conducted by Zoom Webinar.
Open Positions
Career Opportunities
Get in Touch
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Lab Head Email
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Office Phone
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Lab Phone
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Minkui Luo discloses the following relationships and financial interests:
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Doris Duke Charitable Foundation
Provision of Services -
SINO-US Chemistry Professors Conference
Provision of Services (uncompensated) -
ShanghaiTech University
Provision of Services (uncompensated)
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Westlake University
Provision of Services -
Zhejiang University
Provision of Services
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.