Chemical Biology Program

The Minkui Luo Lab

Research

Minkui Luo, PhD

The Luo Lab is interested in developing and leveraging novel approaches at the interface of chemistry and biology to annotate functional roles of epigenetic modulators. Epigenetic regulation is essential for maintaining cellular fates and its dysregulation has been associated with various diseases including cancer. Among key epigenetic modulators are diverse protein methyltransferases/demethylases and methyl-arginine/lysine (Rme/Kme) effector proteins. With novel chemical tools developed in-house, we aim to systematically interrogate Rme/Kme-involved epigenetics with emphasis on novel molecular mechanisms and biological outcomes. The Luo laboratory is also interested in designing and synthesizing epigenetic inhibitors with the emphasis of the distinct modes of action in disease-relevant contexts. Researchers in the Luo Lab with expertise in chemistry, biochemistry and biology work in a highly collaborative manner to develop unprecedent chemical reagents for biological discovery, elucidate disease-causing mechanisms with molecular details, and explore novel treatments against cancer.

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Featured News

In the Lab

Two clusters of colored blobs with a diagram in the middle

Computational “Hive Mind” Helps Scientists Solve an Enzyme’s Cryptic Movements

The breakthrough gives an unprecedented look at the varied and shifting poses of a protein in action.

Q&A

Setting Cancer Cells on the Right Path: A New Leukemia Drug Shows Growing Promise

An experimental drug for acute myelogenous leukemia might potentially help many more patients than previously thought by controlling epigenetic processes, according to a recent MSK study.

Publications Highlights

Cai XC, Zhang T, Kim EJ, Jiang M, Wang K, Wang J, Chen S, Zhang N, Wu H, Li F, Dela Seña CC, Zeng H, Vivcharuk V, Niu X, Zheng W, Lee JP, Chen Y, Barsyte D, Szewczyk M, Hajian T, Ibáñez G, Dong A, Dombrovski L, Zhang Z, Deng H, Min J, Arrowsmith CH, Mazutis L, Shi L, Vedadi M, Brown PJ, Xiang J, Qin LX, Xu W, Luo M. A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. Elife. 2019 Oct 28;8:e47110. This work was highlighted by Elife Digest.

Chen S, Kapilashrami K, Senevirathne C, Wang Z, Wang J, Linscott JA, Luo M. Substrate-Differentiated Transition States of SET7/9-Catalyzed Lysine Methylation. J Am Chem Soc. 2019 May 22;141(20):8064-8067.

Chen S, Wiewiora RP, Meng F, Babault N, Ma A, Yu W, Qian K, Hu H, Zou H, Wang J, Fan S, Blum G, Pittella-Silva F, Beauchamp KA, Tempel W, Jiang H, Chen K, Skene RJ, Zheng YG, Brown PJ, Jin J, Luo C, Chodera JD, Luo M. The dynamic conformational landscape of the protein methyltransferase SETD8. Elife. 2019 May 13;8:e45403. This work was highlighted by Elife Digest, News of Shanghai Institute of Materia Medica, MSKCC Blog, and TPCB Webpage.

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People

Minkui Luo, PhD

Chemical Biologist Minkui Luo develops cutting-edge tools, technologies and concepts to annotate functions of protein-posttranslational modifications and designs inhibitors for cancer therapies.
BS, Fudan University
PhD, Princeton University

[email protected]: Email Address
646-888-3066: Office Phone
Download CV: PDF File

Members

Junyi Wang, MS — Junyi Wang
Research Technician

Ryan Blawski, PhD — Ryan Blawski
Former Research Fellow

Jessica Arlequin

Senior Administrative Assistant

Rohit Chaudhuri

Research Fellow

Deyao Li

Research Fellow

Zhizhong Li

Senior Research Assistant

Yu Zong

Research Fellow

Candice Thompson

Administration Assistant

Gil Blum

Graduate Student

Ian Bothwell

Graduate Student

Han Guo

Graduate Student

Nawei Zhang, MD — Nawei Zhang
Senior Research Scientist

Liudmila Dzhekieva

Postdoctoral Fellow

Chamara Senevirathne, PhD — Chamara Senevirathne
Postdoctoral Fellow

Xiaochuan Cai, PhD — Xiaochuan Cai
Postdoctoral Fellow

Kanishk Kapilashrami

Postdoctoral Fellow

Li Yang

Visiting Professor

Fabio Pittella, PhD — Fabio Pittella
Visiting Investigator

Shi Chen, PhD — Shi Chen
Graduate Student

Cynthia Quintero
Joint Graduate Student with the Gudas Lab

Wei Tan

Joint Postdoctoral Fellow with the Zhao Lab

Fanny Cherblanc

Research Fellow

Jianxian Gong

Research Fellow

Glorymar Ibáñez

Senior Laboratory Technician

Kabirul Islam

Research Fellow

Michael Langberg, PhD — Michael Langberg
Research Fellow

Joshua Linscott

Research Fellow

Jamie McBean

Research Fellow

Michael J Stokes

Graduate Student

Laura Minaya — Laura Vidal
Administrative Assistant

Feng Wang

Research Fellow

Lihui Wang

Visiting Investigator

Rui Wang

Research Fellow

Wei Xiong

Research Fellow

Weihong Zheng

Research Fellow

Achievements

Maximizing Investigators’ Research Award (R35), NIGMS/NIH (2019)
Eli Lilly Award in Biological Chemistry, American Chemical Society (2015)
Clinical & Translational Science Center Novel Award, Weill Cornell Medical College (2014)
Basil O'Connor Starter Scholar, March of Dimes Birth Defects Foundation (2011)
Director’s New Innovator Award, National Institutes of Health (2010)

Alfred W. Bressler Scholar, Alfred W. Bressler Scholars Endowment Fund (2010)
The V Scholar Award, V Foundation for Cancer Research (2009)
Outstanding Postdoctoral Research Prize, Albert Einstein College of Medicine (2007)
Best Presentation Award, 3rd ACS Annual Metropolitan New York Area Poster Program for Graduate Students in the Chemical Sciences (2003)
Rohm & Haas Fellowship, Fudan University (1998)
Du Pont Fellowship, Fudan University (1998)

Open Positions

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Career Opportunities

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Get in Touch

[email protected]

Lab Head Email
646-888-3066

Office Phone
646-888-3067

Lab Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Minkui Luo discloses the following relationships and financial interests:

American Society for Biochemistry and Molecular Biology
Professional Services and Activities (Uncompensated)
Elsevier
Professional Services and Activities
Federation of American Societies for Experimental Biology (FASEB)
Professional Services and Activities (Uncompensated)
Gordon Research Conferences
Professional Services and Activities (Uncompensated)

International Chemical Biology Society
Professional Services and Activities (Uncompensated)
King Abdullah University of Science and Technology
Professional Services and Activities (Uncompensated)
Pacifichem, Inc.
Professional Services and Activities (Uncompensated)
Shenzhen Bay Laboratory
Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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