Morgan Huse: Publications


Er, E. E., Tello-Lafoz, M., and Huse, M. (2022). Mechanoregulation of Metastasis Beyond the Matrix. Cancer Res. 82, 3409-3419.

Wang, M. S., and Huse, M. (2022). Phollow the Phosphoinositol: Actin Dynamics at the B Cell Immune Synapse. J. Cell Bio. 221, e202208015.

Wang, M. S., Hu, Y., Sanchez, E. E., Xie, X., Roy, N. H., de Jesus, M., Winer, B. Y., Zale, E. A., Jin, W., Sachar, C., Lee, J. H., Hong, Y., Kim, M., Kam, L. C., Salaita, K., and Huse, M. (2022). Mechanically Active Integrins Target Lytic Secretion at the Immune Synapse to Facilitate Cellular Cytotoxicity. Nat. Commun. 13, 3222.

Shakiba, M., Zumbo, P., Espinosa-Carrasco, G., Menocal, L., Dündar, F., Carson, S., Bruno, E., Sanchez-Rivera, F., Lowe, S., Camara, S., Koche, R., Reuter, V., Socci, N., Whitlock, B., Tamzalit, F., Huse., M., Hellmann, M., Wells, D., Defranoux, N., Betel, D., Philip, M., and Schietinger, A. (2022). TCR Signal Strength Defines Distinct Mechanisms of T Cell Dysfunction and Cancer Evasion. J. Exp. Med. 219, e20201966.

Mansilla-Soto, J., Eyquem, J., Feucht, J., Hamieh, M., Lindenbergh, P., Sjöstrand, M., Dobrin, A., Iyer, A., Li, Z., Miele, M., Tamzalit, F., Zhao, Z., Giavridis, T., van der Stegen, S., Angus, A. G., Huse, M., Hendrickson, R., Haubner, S., Zucchetti, A., Saetersmoen, M., Paillon, N., Hivroz, C., Maurin, M., Riviere, I, and Sadelain, M. (2022). HLA-independent T Cell Receptors for Targeting Tumors with Low Antigen Density. Nat. Med. 28, 345-352.

Tello-Lafoz, M., de Jesus, M., and Huse, M. (2022). Harder, Better, Faster, Stronger: Biochemistry and Biophysics in the Immunosurveillance Concert. Trends Immunol. 43, 96-105.

Zhang, M., Zhao, Z., Pritykin, Y., Hannum, M., Scott, A. C., Kuo, F., Sanghvi, V., Chan, T. A., Seshan, V., Wendel, H.-G., Schietinger, A., Sadelain, M., and Huse, M. (2021). Ectopic Activation of the miR200c-EpCAM Axis Enhances Anti-tumor T Cell Responses in Models of Adoptive Cell Therapy. Sci. Transl. Med. 13, eabg4328. 

Tello-Lafoz, M., Srpan, K., Sanchez, E. E., Hu, J., Remsik, J., Romin, Y., Calò, A., Hoen, D., Bhanot, U., Morris, L., Boire, A., Hsu, K. C., Massagué, J., Huse, M.*, and Er, E. E.* (2021) Cytotoxic Lymphocytes Target Characteristic Biophysical Vulnerabilities in Cancer. Immunity 54, 1037-1054.  * corresponding authors

Chaudhuri, P. K., Wang, M. S., Black, C. T., Huse. M., and Kam, L. C. (2020). Modulating T Cell Activation Using Depth Sensing Topographic Cues. Adv. Biosyst. 4, e2000143.

Santich, B. H., Park, J. A., Tran, H., Huse, M., and Cheung, N. V. (2020). Interdomain Spacing and Spatial Configuration Drive the Potency of IgG-[L]-scFv T Cell Bispecific Antibodies. Sci. Trans. Med. 12, eaax1315.

Tamzalit, F., Tran, D., Jin, W., Boyko, V., Bazzi, H., Kepecs, A., Kam., L. C., Anderson, K. V., and Huse, M. (2020). Centrioles Control the Capacity, but not the Specificity, of Cytotoxic T Cell Killing. Proc. Nat. Acad. Sci. USA 117, 4310-4319.

Vorselen, D., Wang, Y., De Jesus, M., Shah, P., Footer, M. J., Huse, M., Cai, W., and Theriot, J. A. (2020). Microparticle Traction Force Microscopy Reveals Subcellular Force Exertion Patterns in Immune Cell-Target Interactions. Nat. Commun. 11, 20.

Jin, W., Tamzalit, F., Chaudhuri, P. K., Black, C. T., Huse, M., and Kam, L. C. (2019). T cell Activation and Immune Synapse Organization Respond to the Microscale Mechanics of Structured Surfaces. Proc. Nat. Acad. Sci. USA 116, 19835-19840.

Sanchez, E., Liu, X., and Huse, M. (2019). Actin Clearance Promotes Polarized Dynein Accumulation at the Immunological Synapse. PLoS One 14, e0210377.

Adams, N. M., Geary, C. D., Santosa, E. K., Lumaquin, D., Le Luduec, J. B., Sottile, R., van der Ploeg, K., Hsu, J., Whitlock, B. M., Jackson, B. T., Weizman, O. E., Huse, M., Hsu, K.C., and Sun, J. C. (2019). Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells. Immunity 50, 1381-1390.

Hamieh, M., Dobrin, A., Cabriolu, A., van der Stegen, S. J. C., Giavridis, T., Mansilla-Soto, J., Eyquem, J., Zhao, Z., Whitlock, B. M., Miele, M. M., Li, Z., Cunanan, K. M., Huse, M., Hendrickson, R. C., Wang, X., Riviere, I., and Sadelain, M. (2019). CAR T Cell Trogocytosis and Cooperative Killing Regulate Tumor Antigen Escape. Nature 568, 112-116.

Tamzalit, F., Wang, M. S., Jin, W., Tello-Lafoz, M., Boyko, V., Heddleston, J. M., Black, C. T., Kam, L. C., and Huse, M. (2019). Interfacial Actin Protrusions Mechanically Enhance Killing by Cytotoxic T Cells. Sci. Immunol., eaav5445.

Sanchez, E., and Huse, M. (2018). Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist. J. Vis. Exp. 134, e56655.

Tello-Lafoz, M., Martinez-Martinez, G., Rodriquez-Rodriguez, C., Albar, J.P., Huse, M., Gharbi, S., and Merida, I. (2017). SNX27 Interactome in T Lymphocytes Identifies ZO-2 Dynamic Redistribution at the Immune Synapse. Traffic 18, 491-504.

Oyler-Yaniv, A., Oyler-Yaniv, J., Whitlock, B. M., Liu, Z., Germain, R. N., Huse, M., Altan-Bonnet, G., and Krichevsky, O. (2017). A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System. Immunity 46, 609-620.

Jin, W., Black, C. T., Kam, L. C., and Huse, M. (2017). Probing Synaptic Biomechanics Using Micropillar Arrays. In Cosima T. Baldari (Ed.), Methods in Molecular Biology, the Immune Synapse (pp. 333-346). Switzerland: Springer.

Huse, M. (2017). Mechanical Forces in the Immune System. Nat. Rev. Immunol. 17, 679-690.

Basu, R., and Huse, M. (2016). Mechanical Communication at the Immunological Synapse. Trends Cell Bio. 27, 241-254.

Cheng, M., Santich, B., Xu, H., Ahmed, M., Huse, M., and Cheung, N. V. (2016). Successful Engineering of a Highly Potent Single-Chain-Variable-Fragment (scFv) Bispecific Antibody to Target Disialoganglioside (GD2) Positive Tumors. Oncoimmunology 5, e1168557.

Basu, R., Whitlock, B. M., Husson, J., Le Floc’h, A., Jin, W., Oyler-Yaniv, A., Dotiwala, F., Giannone, G., Hivroz, C., Biais, N., Lieberman, J., Kam, L. C., and Huse, M. (2016). Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing. Cell 165, 100-110.

Dadi, S., Chhangawala, S., Whitlock, B. M., Franklin, R. A., Luo, C. T., Oh, S. A., Toure, A., Pritykin, Y., Huse, M., Leslie, C. R., and Li, M. O. (2016). Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells. Cell 164, 365-377.

Nguyen Duc, T., and Huse, M. (2015). A Generalizable Platform for the Photoactivation of Cell Surface Receptors. ACS Chem. Bio. 10, 2435-2440.

Huse, M. (2014). Lipid-based Patterning of the Immunological Synapse. Biochem. Soc. Trans. 42, 1506-1511.

Chauveau, A., Le Floc’h, A., Bantilan, N. S., Koretzky, G. A., and Huse, M. (2014). Diacylglycerol Kinase α Establishes T Cell Polarity by Shaping Diacylglycerol Accumulation at the Immunological Synapse. Sci. Signal. 7, ra82.

Bashour, K. T., Gondarenko, A., Chen, H., Shen, K., Liu, X., Huse, M., Hone, J. C., and Kam, L. C. (2014). CD28 and CD3 Have Complementary Roles in T-cell Traction Forces. Proc. Nat. Acad. Sci. USA 111, 2241-2246.

Le Floc’h, A. Tanaka, Y., Bantilan, N. S., Voisinne, G., Altan-Bonnet, G., Fukui, Y., and Huse, M. (2013). Annular PIP3 Accumulation Controls Actin Architecture and Modulates Cytotoxicity at the Immunological Synapse. J. Exp. Med. 210, 2721-2737.

Liu, X., Kapoor, T. M., Chen, J. K., and Huse, M. (2013). Diacylglycerol Promotes Centrosome Polarization in T Cells via Reciprocal Localization of Dynein and Myosin II. Proc. Nat. Acad. Sci. USA 110, 11976-11981.

Gasteiger, G., Hemmers, S., Firth, M. A., Le Floc’h, A., Huse, M., Sun, J. C., and Rudensky, A. Y. (2013). IL-2-dependent Tuning of NK Cell Sensitivity for Target Cells is Controlled by Regulatory T Cells. J. Exp. Med. 210, 1167-1178.

Pittari G., Liu X. R., Selvakumar A., Zhao Z., Merino E., Huse M., Chewning J. H., Hsu K. C., and Dupont B. (2013). NK Cell Tolerance of Self-Specific Activating Receptor KIR2DS1 in Individuals with Cognate HLA-C2 Ligand. J. Immunol. 190, 4650-4660.

Huse, M., Milanoski, S. C., and Abeyweera, T. P. (2013). Building Tolerance by Dismantling Synapses: Inhibitory Receptor Signaling in Natural Killer Cells.  Immunol. Rev. 251, 143-153.

Ouyang, W., Liao, W., Luo, C.T., Yin, N., Huse, M., Kim, M.V., Peng, M., Chan, P., Ma, Q., Mo, Y., Meijer, D., Zhao, K., Rudensky, A.Y., Atwal, G., Zhang, M.Q., and Li, M.O. (2012). Novel Foxo1-dependent Transcriptional Programs Control T(reg) Cell Function. Nature 491, 554-559.

Merino, E., Abeyweera, T. P., Firth, M. A., Zawislak, C. L., Basu, R., Liu, X., Sun, J. C., and Huse, M. (2012). Protein Kinase C-q Clustering at Immunological Synapses Amplifies Effector Responses in Natural Killer Cells. J. Immunol. 189, 4859-4869.

Huse, M. (2012). Microtubule-Organizing Center Polarity and the Immunological Synapse: Protein Kinase C and Beyond.  Front. Immunol. 3, 235.

Huse, M. (2011). Lymphocyte Polarity, the Immunological Synapse and the Scope of Biological Analogy.  Bioarchitecture 1, 180-185.

Quann, E. J., Liu, X., Altan-Bonnet, G., and Huse, M. (2011). A Cascade of Protein Kinase C Isozymes Promotes Cytoskeletal Polarization in T Cells. Nat. Immunol. 12, 647-654.

Abeyweera, T. P., Merino, E., and Huse, M. (2011) Inhibitory Signaling Blocks Activating Receptor Clustering and Induces Cytoskeletal Retraction in Natural Killer Cells. J. Cell Biol. 192, 675-690.

Huse, M. (2010). Photochemical Approaches to T-cell Activation. Immunol. 130, 151-157.

Kuhns, M. S., Girvin, A. T., Klein, L. O., Chen, R., Jensen, K. D. C., Newell, E. W., Huppa, J. B., Lillemeier, B. F., Huse, M., Chien, Y., Garcia, K. C., and Davis, M. M. (2010). Evidence for a Functional Sidedness to the abTCR. Proc. Nat. Acad. Sci. USA 107, 5094-5099.

Quann, E. J., Merino, E., Furuta, T., and Huse, M. (2009). Localized Diacylglycerol Drives the Polarization of the Microtubule-Organizing Center in T cells. Nat. Immunol. 10, 627-635.

Huse, M. (2009). The T-cell-receptor Signaling Network. J. Cell Sci. 122, 1269-1273.

Huse, M., Quann, E. J., and Davis, M. M. (2008). Shouts, Whispers, and the Kiss of Death: Directional Secretion in T cells. Nat. Immunol. 9, 1105-1111.

Huse, M.*, Klein, L. O.*, Girvin, A. T., Faraj, J. M., Li, Q., Kuhns, M. S., and Davis, M. M. (2007). Spatial and Temporal Dynamics of T Cell Receptor Signaling with a Photoactivatable Agonist. Immunity 27, 76-88. * equal contribution

Davis, M. M., Krogsgaard, M., Huse, M., Huppa, J., Lillemeier, B. F., and Li, Q.-J. (2007). T Cells as a Self-Referential, Sensory Organ. Annu. Rev. Immunol. 25, 681-695.

Huse, M., Lillemeier, B. F., Kuhns, M. S., Chen, D. S., and Davis, M. M. (2006).  T Cells Use Two Directionally Distinct Pathways for Cytokine Secretion. Nat. Immunol. 7, 247-255.

Krogsgaard, M., Li, Q.-J., Sumen, C., Huppa, J. B., Huse, M., and Davis, M. M. (2005). Agonist/Self Peptide-MHC Heterodimers Drive T Cell Activation and Sensitivity. Nature 434, 238-243.

Ottesen J. J., Huse, M., Sekedat, M. D., and Muir, T. W. (2004). Semisynthesis of Phosphovariants of Smad2 Reveals a Substrate Preference for the Activated TbRI Kinase. Biochemistry 43, 5698-5706.

Huse, M. and Kuriyan, J. (2002). The Conformational Plasticity of Protein Kinases. Cell 109, 275-282.

Huse, M. (2002).  Structural Biology: Alive and Skiing.  Structure 10, 137-138.

Flavell, R. R., Huse, M., Goger, M., Trester-Zedlitz, M., Kuriyan, J., and Muir, T. W. (2002).  Efficient Semi-synthesis of a Tetraphosphorylated Analog of the Type I TGFb Receptor. Org. Lett.4,165-168.

Wu, J.-W., Hu, M., Chai, J., Seoane, J., Huse, M., Li, C., Rigotti, D. J., Kyin, S., Muir, T. W., Fairman, R., Massagué, J., and Shi, Y. (2001).  Crystal Structure of Phosphorylated Smad2: Recognition of Phosphoserine by the MH2 Domain and Insights on Smad Function in TGF-b Signaling. Mol. Cell 8, 1277-1289.

Huse, M., Muir, T. W., Xu, L., Chen, Y.-G., Kuriyan, J., and Massagué, J. (2001). The TGFb Receptor Activation Process: An Inhibitor- to Substrate-binding Switch. Mol. Cell 8, 671-682.

Huse, M., Holford, M. N., Kuriyan J., and Muir, T. W. (2000).  Semi-synthesis of Hyperphosphorylated Type I TGFb Receptor: Addressing the Mechanism of Kinase Activation. J. Am. Chem. Soc. 122, 8337-8338.

Huse, M., Chen, Y. G., Massagué, J., and Kuriyan, J. (1999).  Crystal Structure of the Cytoplasmic Domain of the Type I TGFb Receptor in Complex with FKBP12.  Cell 96, 425-436.

Huse, M., Eck, M. J., and Harrison, S. C. (1998).  A Zn2+ Ion Links the Cytoplasmic Tail of CD4 to the N-terminal Region of Lck.  J. Biol. Chem. 273, 18729-18733.

Moarefi, I., LaFevre-Bernt, M., Sicheri, F., Huse, M., Lee, C.-H., Kuriyan, J., and Miller, W. T. (1997). Activation of the Src-family Tyrosine Kinase Hck by SH3 Domain Displacement.  Nature 385, 650-653.