Our research group is interested in the structural biology of pathways that are altered in cancer, with particular emphasis on pathways that control the growth and proliferation of the cell. In cancer, mutations and other alterations in these pathways lead to the uncoupling of cell growth from growth-regulatory signals and contribute to the unrestricted proliferation of the tumor cell.
Nikola P. Pavletich, PhD
Professor
Research Focus
The Pavletich laboratory studies the structural biology of oncogenes and tumor suppressors.Education
PhD, Johns Hopkins University- Office Phone: 212-639-8544
- Lab Phone: 212-639-8547
- Lab Fax: 212-717-3135
Lab Members
Yehuda Goldgur
Associate Laboratory Member & Head, X-Ray Crystallography core Facility
Buren Li
Research Technician
Nikola Pavletich
Member
Madellyn Sosa
Administrative Assistant
Renjing Wang
Research Fellow
Haijuan Yang
Senior Research Scientist
Ankita Dhar
Research Assistant
Buren Li
Graduate Student
Publications
- Yang, H., Rudge, D.G., Koos, J.D., Vaidialingam, B., Yang, H.J. & Pavletich, N.P. mTOR kinase structure, mechanism and regulation. Nature 497, 217-223 (2013).
- Wang, R., Persky, N., Yoo, B., Ouerfelli, O., Smogorzewska, A., Elledge, S. J. & Pavletich, N.P. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science 346, 1127-30 (2014).
