Structural Biology Program

The Nikola Pavletich Lab

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Research

Pictured: Dr. Nikola Pavletich
Nikola P. Pavletich, PhD

Our research group is interested in the structural biology of pathways that are altered in cancer, with particular emphasis on pathways that control the growth and proliferation of the cell. In cancer, mutations and other alterations in these pathways lead to the uncoupling of cell growth from growth-regulatory signals and contribute to the unrestricted proliferation of the tumor cell.

Nikola Pavletich Lab Group

Featured News

Structure of an intermediate during the homologous recombination reaction.
Wielding Powerful Imaging Tools, MSK Researchers Decipher Process of DNA Repair

In the Lab
Pictured: Three-dimensional structure of the protein mTOR
A Recently Revealed Protein Structure Creates New Opportunities for Cancer Research and Drug Design

Honors
Pictured: Nikola Pavletich and Alexander Rudensky
Two Memorial Sloan Kettering Investigators Named to National Academy of Sciences

Publications

Yang, H., Rudge, D.G., Koos, J.D., Vaidialingam, B., Yang, H.J. & Pavletich, N.P. mTOR kinase structure, mechanism and regulation. Nature 497, 217-223 (2013).

Wang, R., Persky, N., Yoo, B., Ouerfelli, O., Smogorzewska, A., Elledge, S. J. & Pavletich, N.P. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science 346, 1127-30 (2014).

Zhou, C., Pourmal, S. & Pavletich, N. P. Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. eLife 4:e09832 (2015).

Yang, H., Jiang, X., Li, B., Yang, H.J., Miller, M., Yang, A., Dhar, A. & Pavletich, N.P. Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature 552, 368-373 (2017).

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People

Pictured: Dr. Nikola Pavletich

Nikola P. Pavletich, PhD

  • The Pavletich laboratory studies the structural biology of oncogenes and tumor suppressors.
  • PhD, Johns Hopkins University
nikola@xray2.mskcc.org
Email Address
212-639-8544
Office Phone

Members

Yehuda Goldgur
Yehuda Goldgur

Associate Laboratory Member & Head, X-Ray Crystallography core Facility

Buren Li
Buren Li

Research Technician

Nikola Pavletich, PhD
Nikola Pavletich

Member

Madellyn Sosa
Madellyn Sosa

Administrative Assistant

Renjing Wang
Renjing Wang

Research Fellow

Haijuan Yang
Haijuan Yang

Senior Research Scientist

Marie Benton
Marie Benton
Ankita Dhar
Ankita Dhar

Research Assistant

Buren Li
Buren Li

Graduate Student

Christopher Peralta
Christopher Peralta
Christopher Warren
Christopher Warren
Lab Affilations

Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Nikola P. Pavletich discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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