Molecular Biology Program

The Scott Keeney Lab

Research

Pictured: Dr. Scott Keeney
Scott Keeney, PhD

The long-range objectives of our research are to understand the mechanism of meiotic recombination and to determine how this process is coordinated with other events of meiotic prophase. Several projects in the lab focus on Spo11 (the protein that makes the DNA double-strand breaks (DSBs) that initiate recombination), the proteins that interact with Spo11, the interactions of these proteins with meiotic chromosomes, and the mechanisms that regulate the timing, number, and location of DSB formation. We also study how DSBs are processed and repaired and we are seeking to expand knowledge of meiotic processes more generally through discovery of new genes important for germ cell function. Most of the meiosis research in the lab uses the yeast Saccharomyces cerevisiae and the mouse. Finally, our studies of Spo11 have also provided an entry point to research on the DSBs made by the enzyme Topoisomerase II when it is inhibited by chemotherapeutic agents such as etoposide or doxorubicin.

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Research Projects

Scott Keeney Lab Group

Publications

People

Pictured: Dr. Scott Keeney

Scott Keeney, PhD

  • Molecular biologist Scott Keeney investigates mechanisms of the initiation of meiotic recombination.
  • PhD, University of California, Berkeley
212-639-5182
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Members

Laurent Acquaviva
Laurent Acquaviva

Research Fellow

Devanshi Jain, PhD
Devanshi Jain

Research Fellow

Xiaojing Mu

Weill Graduate Student

Hajime Murakami

Senior Research Scientist

Meret Arter
Meret Arter

Research Fellow

Diana Yeelam Eng

Research Technician

Pei-Ching (Peggy) Huang

Graduate Student

Soonjoung Kim

Postdoctoral Fellow

Tao Li
Tao Li

Research Fellow

Kaixian Liu
Kaixian Liu

Research Fellow

Min Lu
Min Lu

Research Fellow

Marina Marcet
Marina Marcet

Research Fellow

Thierry N’Tumba-Byn

Research Fellow

David Ontoso

Research Fellow

Stephen Pu

Research Technician

Denise Ramirez

Administrative Assistant

Manoj Thakur
Manoj Thakur

Research Fellow

Jiaqi Xu
Jiaqi Xu

Graduate Student

Shintaro Yamada

Research Fellow

Lab Alumni
Esther de Boer

Research Fellow

James Dowdle

Graduate Student

Sam Globus

Graduate Student

Liisa Kauppi

Research Fellow

Ryan Kniewel

Graduate Student

Mariko Sasaki

Graduate Student

Corentin Claeys Bouuaert

Research Fellow

Erman Karasu
Mehmet Erman Karasu

Postdoctoral Researcher at ETH Zurich, Zurich, Switzerland

Sarah Kim, PhD
Sarah Kim

Research Fellow

Isabel Lam
Isabel Lam

Graduate Student

Julian Lange

Research Fellow

Monika Mehta

Research Fellow

Eleni Mimitou

Research Fellow

Neeman Mohibullah

Research Fellow

Jodi-Ann Sampson

Research Technician

Drew Thacker

Graduate Student

Sam Tischfield

Graduate Student

Luis Torres

Research Technician

Megan van Overbeek, PhD
Megan van Overbeek

Research Associate

Xuan Zhu
Xuan Zhu

Graduate Student

Michiel Boekhout

Research Fellow

George Chung

Postdoctoral Fellow

Erman Karasu, Research Fellow
Erman Karasu

Research Fellow

Jacquelyn Song

Research Technician

Charanjit Arora

Graduate Research Assistant

Robert Diaz
Monica DiGiacomo

Research Fellow

Kiersten Henderson

Graduate Research Assistant

Kehkooi Kee
Shohreh Maleki

Research Fellow

Emmanuelle Martini
Matthew Neale
Takashi Okada

Research Fellow

Jing Pan

Research Fellow

Ignasi Roig

Research Fellow

Vijayalakshmi Subramanian

Research Fellow

Lab Affilations

Achievements

  • Investigator, Howard Hughes Medical Institute (2008)
  • American Academy of Microbiology (2014)
  • American Academy of Arts and Sciences (2017)
  • Frederick Adler Chair, MSKCC (2017)
  • US National Academy of Sciences (2020)

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Scott Keeney discloses the following relationships and financial interests:

  • AbbVie
    Ownership / Equity Interests
  • Abbott Laboratories
    Ownership / Equity Interests
  • Pfizer, Inc.
    Ownership / Equity Interests

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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