The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches (including virology, biochemistry, structural biology, and genetics) and applies them to model systems ranging from viruses to bacteria to fungi to mammalian cells. An explicit aim is to identify novel enzymatic targets for treatment of human diseases.
Stewart Shuman, MD, PhD
American Cancer Society Research Professor; Professor
Research Focus
The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.Education
- B.A. Biology (1976) Wesleyan University
- Ph.D. Molecular Biology (1983) Albert Einstein College of Medicine
- M.D. (1981) Albert Einstein College of Medicine
- Office Phone: 212-639-7145
- Lab Phone: 212-639-7143
Lab Members
Research Scholar
Research Scholar
Research Senior Scientist
Member
Publications
- Schwer, B., Bitton, D.A., Sanchez, A.M., Bähler, J., and Shuman, S. (2014) Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast. Proc. Natl. Acad. Sci. USA 111, 4185-4190.
- Chakravarty, A.K., Smith, P., Jalan, R., and Shuman, S. (2014) Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination. Cell Reports 7, 339-347.
Selected Achievements
- Member of the American Academy of Arts and Sciences (2015)
- Fellow of the American Academy of Microbiology (2013)
- NIH MERIT Award (2007)
- American Cancer Society Research Professor (2005 - )
- American Society for Virology, Wolfgang Joklik Lectureship (2004)
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- Burroughs Wellcome Fund Award - New Initiatives in Malaria Research (2001-03)
- Simon H. Rifkind Chair, Sloan-Kettering Institute (1999 - )
- American Cancer Society Faculty Research Award (1994-99)
- Pew Scholar (1990-94)
- American Cancer Society Junior Faculty Research Award (1989-92)
- Alpha Omega Alpha (1982)
- Phi Beta Kappa (1975)
