Molecular Biology Program

The Stewart Shuman Lab

Research

Pictured: Dr. Stewart Shuman
Stewart Shuman, MD, PhD
The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches (including virology, biochemistry, structural biology, and genetics) and applies them to model systems ranging from viruses to bacteria to fungi to mammalian cells. An explicit aim is to identify novel enzymatic targets for treatment of human diseases. 

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Research Projects

Stewart Shuman Lab Group

Publications

Schwer, B., Bitton, D.A., Sanchez, A.M., Bähler, J., and Shuman, S. (2014) Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast. Proc. Natl. Acad. Sci. USA 111, 4185-4190.

Chakravarty, A.K., Smith, P., Jalan, R., and Shuman, S. (2014) Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination. Cell Reports 7, 339-347.

Das, U., Chauleau, M., Ordonez, H., and Shuman, S. (2014) Impact of DNA3’pp5’G capping on repair reactions at DNA 3’ ends. Proc. Natl. Acad. Sci. USA 111, 11317-11322.

Unciuleac, M.C., Goldgur, Y., and Shuman, S. (2015) Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase. Proc. Natl. Acad. Sci. USA 112, 13868-13873.

Unciuleac, M.C., Goldgur, Y., and Shuman, S. (2017) Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD+-dependent polynucleotide ligases. Proc. Natl. Acad. Sci USA 114, 2592-2597.

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People

Pictured: Dr. Stewart Shuman

Stewart Shuman, MD, PhD

  • The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.
  • B.A. Biology (1976) Wesleyan University
  • Ph.D. Molecular Biology (1983) Albert Einstein College of Medicine
  • M.D. (1981) Albert Einstein College of Medicine
212-639-7145
Office Phone
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Members

Bradley Benjamin
Bradley Benjamin

GSK Graduate Student

Swathi Dantuluri
Swathi Dantuluri

Research Fellow

Angad Garg, Ph.D
Angad Garg

Senior Research Scientist

Shreya Ghosh, PhD
Shreya Ghosh

Research Scholar

Ana M. Sanchez
Ana M. Sanchez

GSK Graduate Student

Garrett Warren
Garrett Warren

Research Scholar

Stewart Shuman
Stewart Shuman

Member

Lab Affiliations

Achievements

  • Member of the American Academy of Arts and Sciences (2015)
  • Fellow of the American Academy of Microbiology (2013)
  • NIH MERIT Award (2007)
  • American Cancer Society Research Professor (2005 - )
  • American Society for Virology, Wolfgang Joklik Lectureship (2004)
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  • Burroughs Wellcome Fund Award - New Initiatives in Malaria Research (2001-03)
  • Simon H. Rifkind Chair, Sloan-Kettering Institute (1999 - )
  • American Cancer Society Faculty Research Award (1994-99)
  • Pew Scholar (1990-94)
  • American Cancer Society Junior Faculty Research Award (1989-92)
  • Alpha Omega Alpha (1982)
  • Phi Beta Kappa (1975)

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