Molecular Biology Program

The Stewart Shuman Lab

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Research

Pictured: Dr. Stewart Shuman
Stewart Shuman, MD, PhD
The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches (including virology, biochemistry, structural biology, and genetics) and applies them to model systems ranging from viruses to bacteria to fungi to mammalian cells. An explicit aim is to identify novel enzymatic targets for treatment of human diseases. 

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Research Projects

Stewart Shuman Lab Group

Featured News

Pictured: Maria Jasin
Studies Provide New Insight into Fundamental Biological Process

Publications

Schwer, B., Bitton, D.A., Sanchez, A.M., Bähler, J., and Shuman, S. (2014) Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast. Proc. Natl. Acad. Sci. USA 111, 4185-4190.

Chakravarty, A.K., Smith, P., Jalan, R., and Shuman, S. (2014) Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination. Cell Reports 7, 339-347.

Das, U., Chauleau, M., Ordonez, H., and Shuman, S. (2014) Impact of DNA3’pp5’G capping on repair reactions at DNA 3’ ends. Proc. Natl. Acad. Sci. USA 111, 11317-11322.

Unciuleac, M.C., Goldgur, Y., and Shuman, S. (2015) Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase. Proc. Natl. Acad. Sci. USA 112, 13868-13873.

Unciuleac, M.C., Goldgur, Y., and Shuman, S. (2017) Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD+-dependent polynucleotide ligases. Proc. Natl. Acad. Sci USA 114, 2592-2597.

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People

Pictured: Dr. Stewart Shuman

Stewart Shuman, MD, PhD

  • The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.
  • B.A. Biology (1976) Wesleyan University
  • Ph.D. Molecular Biology (1983) Albert Einstein College of Medicine
  • M.D. (1981) Albert Einstein College of Medicine
s-shuman@ski.mskcc.org
Email Address
212-639-7145
Office Phone
Download CV
PDF File

Members

Bradley Benjamin
Bradley Benjamin

GSK Graduate Student

Swathi Dantuluri
Swathi Dantuluri

Research Fellow

Angad Garg, Ph.D
Angad Garg

Research Scholar

Shreya Ghosh, PhD
Shreya Ghosh

Research Scholar

Garrett Warner
Garrett Warner

Research Scholar

Mihaela-Carmen Sandu (Unciuleac), PhD
Mihaela-Carmen Sandu (Unciuleac)

Research Senior Scientist

Stewart Shuman
Stewart Shuman

Member

Lab Affilations

Achievements

  • Member of the American Academy of Arts and Sciences (2015)
  • Fellow of the American Academy of Microbiology (2013)
  • NIH MERIT Award (2007)
  • American Cancer Society Research Professor (2005 - )
  • American Society for Virology, Wolfgang Joklik Lectureship (2004)
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  • Burroughs Wellcome Fund Award - New Initiatives in Malaria Research (2001-03)
  • Simon H. Rifkind Chair, Sloan-Kettering Institute (1999 - )
  • American Cancer Society Faculty Research Award (1994-99)
  • Pew Scholar (1990-94)
  • American Cancer Society Junior Faculty Research Award (1989-92)
  • Alpha Omega Alpha (1982)
  • Phi Beta Kappa (1975)

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Stewart Shuman discloses the following relationships and financial interests:

  • Imvaq Therapeutics
    Intellectual Property Rights; Ownership / Equity Interests; Provision of Services
  • Iridia Inc
    Ownership / Equity Interests; Provision of Services (uncompensated)

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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