Molecular Biology Program

The Stewart Shuman Lab

Research

Stewart Shuman, MD, PhD

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches (including virology, biochemistry, structural biology, and genetics) and applies them to model systems ranging from viruses to bacteria to fungi to mammalian cells. An explicit aim is to identify novel enzymatic targets for treatment of human diseases.

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Research Projects

Publications

Schwer, B., Bitton, D.A., Sanchez, A.M., Bähler, J., and Shuman, S. (2014) Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast. Proc. Natl. Acad. Sci. USA 111, 4185-4190.

Chakravarty, A.K., Smith, P., Jalan, R., and Shuman, S. (2014) Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination. Cell Reports 7, 339-347.

Das, U., Chauleau, M., Ordonez, H., and Shuman, S. (2014) Impact of DNA_3’pp_5’G capping on repair reactions at DNA 3’ ends. Proc. Natl. Acad. Sci. USA 111, 11317-11322.

Unciuleac, M.C., Goldgur, Y., and Shuman, S. (2015) Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase. Proc. Natl. Acad. Sci. USA 112, 13868-13873.

Unciuleac, M.C., Goldgur, Y., and Shuman, S. (2017) Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD⁺-dependent polynucleotide ligases. Proc. Natl. Acad. Sci USA 114, 2592-2597.

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People

Stewart Shuman, MD, PhD

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.
B.A. Biology (1976) Wesleyan University
Ph.D. Molecular Biology (1983) Albert Einstein College of Medicine
M.D. (1981) Albert Einstein College of Medicine