Molecular Biology Program

The Stewart Shuman Lab

Research

Stewart Shuman, MD, PhD

Simon H. Rifkind Chair

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches (including virology, biochemistry, structural biology, and genetics) and applies them to model systems ranging from viruses to bacteria to fungi to mammalian cells. An explicit aim is to identify novel enzymatic targets for treatment of human diseases.

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Research Projects

Publications Highlights

Schwer, B., Bitton, D.A., Sanchez, A.M., Bähler, J., and Shuman, S. (2014) Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast. Proc. Natl. Acad. Sci. USA 111, 4185-4190.

Chakravarty, A.K., Smith, P., Jalan, R., and Shuman, S. (2014) Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination. Cell Reports 7, 339-347.

Das, U., Chauleau, M., Ordonez, H., and Shuman, S. (2014) Impact of DNA_3’pp_5’G capping on repair reactions at DNA 3’ ends. Proc. Natl. Acad. Sci. USA 111, 11317-11322.

Unciuleac, M.C., Goldgur, Y., and Shuman, S. (2015) Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase. Proc. Natl. Acad. Sci. USA 112, 13868-13873.

Unciuleac, M.C., Goldgur, Y., and Shuman, S. (2017) Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD⁺-dependent polynucleotide ligases. Proc. Natl. Acad. Sci USA 114, 2592-2597.

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People

Stewart Shuman, MD, PhD

Simon H. Rifkind Chair

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.
B.A. Biology (1976) Wesleyan University
Ph.D. Molecular Biology (1983) Albert Einstein College of Medicine
M.D. (1981) Albert Einstein College of Medicine

[email protected]: Email Address
212-639-7145: Office Phone
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Members

Jill Babor

Shreya Ghosh

Senior Research Scientist

Aleksei Innokentev

Research Scholar

Ana M. Sanchez

GSK Graduate Student

Apurba Sarkar

Research Scholar

Garrett Warren

Research Scholar

Stewart Shuman

Member

Achievements

Member of the American Academy of Arts and Sciences (2015)
Fellow of the American Academy of Microbiology (2013)
NIH MERIT Award (2007)
American Cancer Society Research Professor (2005 - )
American Society for Virology, Wolfgang Joklik Lectureship (2004)

Burroughs Wellcome Fund Award - New Initiatives in Malaria Research (2001-03)
Simon H. Rifkind Chair, Sloan-Kettering Institute (1999 - )
American Cancer Society Faculty Research Award (1994-99)
Pew Scholar (1990-94)
American Cancer Society Junior Faculty Research Award (1989-92)
Alpha Omega Alpha (1982)
Phi Beta Kappa (1975)

Open Positions

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Get in Touch

[email protected]

Lab Head Email
212-639-7145

Office Phone
212-639-7143

Lab Phone

Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Stewart Shuman discloses the following relationships and financial interests:

Cymba X, LLC
Equity; Professional Services and Activities (Uncompensated)

Thermo Fisher Scientific, Inc
Intellectual Property Rights

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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