Molecular Biology Program
The Stewart Shuman Lab
Research

Research Projects

Featured News
Publications
Schwer, B., Bitton, D.A., Sanchez, A.M., Bähler, J., and Shuman, S. (2014) Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast. Proc. Natl. Acad. Sci. USA 111, 4185-4190.
Chakravarty, A.K., Smith, P., Jalan, R., and Shuman, S. (2014) Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination. Cell Reports 7, 339-347.
Das, U., Chauleau, M., Ordonez, H., and Shuman, S. (2014) Impact of DNA3’pp5’G capping on repair reactions at DNA 3’ ends. Proc. Natl. Acad. Sci. USA 111, 11317-11322.
Unciuleac, M.C., Goldgur, Y., and Shuman, S. (2015) Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase. Proc. Natl. Acad. Sci. USA 112, 13868-13873.
Unciuleac, M.C., Goldgur, Y., and Shuman, S. (2017) Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD+-dependent polynucleotide ligases. Proc. Natl. Acad. Sci USA 114, 2592-2597.
People

Stewart Shuman, MD, PhD
- The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.
- B.A. Biology (1976) Wesleyan University
- Ph.D. Molecular Biology (1983) Albert Einstein College of Medicine
- M.D. (1981) Albert Einstein College of Medicine
- s-shuman@ski.mskcc.org
- Email Address
- 212-639-7145
- Office Phone
- Download CV
- PDF File
Members



- Ph.D, Molecular and Cellular Biology, Stony Brook



- Ph.D (2003), University of Freiburg, Germany Doctoral Thesis “Structure and function of key enzymes in the anaerobic aromatic metabolism”. M.S. (1999), Al. I. Cuza University (Iasi, Romania) B.S. (1997) Al. I. Cuza University (Iasi, Romania)

GSK Graduate Student

Research Fellow

Research Scholar

Research Scholar

Research Scholar

Research Senior Scientist

Member
Lab Affilations
Achievements
- Member of the American Academy of Arts and Sciences (2015)
- Fellow of the American Academy of Microbiology (2013)
- NIH MERIT Award (2007)
- American Cancer Society Research Professor (2005 - )
- American Society for Virology, Wolfgang Joklik Lectureship (2004)
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- Burroughs Wellcome Fund Award - New Initiatives in Malaria Research (2001-03)
- Simon H. Rifkind Chair, Sloan-Kettering Institute (1999 - )
- American Cancer Society Faculty Research Award (1994-99)
- Pew Scholar (1990-94)
- American Cancer Society Junior Faculty Research Award (1989-92)
- Alpha Omega Alpha (1982)
- Phi Beta Kappa (1975)
Get in Touch
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Lab Head Email
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Office Phone
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Lab Phone
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Stewart Shuman discloses the following relationships and financial interests:
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Imvaq Therapeutics
Intellectual Property Rights; Ownership / Equity Interests; Provision of Services
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Iridia Inc
Ownership / Equity Interests; Provision of Services (uncompensated)
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.