The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches (including virology, biochemistry, structural biology, and genetics) and applies them to model systems ranging from viruses to bacteria to fungi to mammalian cells. An explicit aim is to identify novel enzymatic targets for treatment of human diseases.
Stewart Shuman, MD, PhD
American Cancer Society Research Professor; Professor
Research Focus
The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.Education
- B.A. Biology (1976) Wesleyan University
- Ph.D. Molecular Biology (1983) Albert Einstein College of Medicine
- M.D. (1981) Albert Einstein College of Medicine
- Office Phone: 212-639-7145
- Lab Phone: 212-639-7143
Lab Members
Anam Ejaz
Graduate Student
Angad Garg
Research Scholar
Shreya Ghosh
Research Scholar
Radhika Jalan
Graduate Student
Annum Munir
Graduate Student
Barbara Remus
Senior Research Scientist
Brad Schmier
Research Fellow
Loressa Uson
Graduate Student
Mihaela-Carmen Sandu (Unciuleac)
Research Senior Scientist
Peihong Dai
Research Assistant
Stewart Shuman
Member
Publications
- Schwer, B., Bitton, D.A., Sanchez, A.M., Bähler, J., and Shuman, S. (2014) Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast. Proc. Natl. Acad. Sci. USA 111, 4185-4190.
- Chakravarty, A.K., Smith, P., Jalan, R., and Shuman, S. (2014) Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination. Cell Reports 7, 339-347.
Selected Achievements
- Member of the American Academy of Arts and Sciences (2015)
- Fellow of the American Academy of Microbiology (2013)
- NIH MERIT Award (2007)
- American Cancer Society Research Professor (2005 - )
- American Society for Virology, Wolfgang Joklik Lectureship (2004)
