Developmental Biology Program
The Thomas Vierbuchen Lab
The Vierbuchen laboratory seeks to elucidate fundamental mechanisms governing the production of the myriad neuronal cell types required to build functioning neural circuits. To model these dynamic developmental processes, we direct the differentiation of mouse and human pluripotent stem cells into specific neuronal cell types in a dish. This reductionist system allows us to recapitulate neural tube patterning and neuronal differentiation under controlled conditions and at a scale that makes it possible to use genetic screens, genomics, and systems genetics to characterize the underlying cell signaling and gene regulatory processes with unprecedented resolution. In the long term, we will apply these insights to better understand the complex genetic underpinnings of psychiatric and neurodegenerative disease.
Vierbuchen T*, Ling E*, Cowley C, Couch C, Harmin DA, Wang X, Roberts CW, Greenberg ME. AP-1 transcription factors and the BAF complex mediate signal-dependent enhancer selection. Molecular Cell 68, 1067-1082 (2017)
Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Sudhof T, Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035–1041 (2010)
Thomas S. Vierbuchen, PhD
- The Vierbuchen laboratory directs the differentiation of mouse and human pluripotent stem cells to characterize fundamental mechanisms of neuronal cell fate specification and function.
- PhD, Stanford University School of Medicine
- [email protected]
- Email Address
- Josie Robertson Investigator (2018-2023)
- David Hubel Award, Neurobiology Department, Harvard Medical School (2017)
- HHMI Fellow of the Damon Runyon Cancer Research Foundation (2014-2018)
- Harold M. Weintraub Graduate Student Award (2013)
- Collegiate Inventors Competition (Finalist, 2010)
Lab News & Events
Stem Cell Zoo to Study Mechanisms for Species-Specific Developmental Time
Memorial Sloan Kettering Cancer Center
Rockefeller Research Laboratories
430 East 67th Street
New York, NY 10065
Rachel Glenn, T32 in Developmental and Stem Cell Biology (2022-2024)
Ann K. Baako, MERIT Mandel Predoctoral Fellowship (2023)
Daniel Medina Cano, NYSTEM Training Award at Center for Stem Cell Biology (2020-2022)
Yuan Lin, NYSTEM Training Award at Center for Stem Cell Biology (2022)
Rachel Glenn, National Science Foundation Graduate Research Fellowship - Honorable Mention (2021)
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Thomas S. Vierbuchen discloses the following relationships and financial interests:
Intellectual Property Rights; Ownership / Equity Interests
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