Cancer Biology & Genetics Program

The Tuomas Tammela Lab

Research

Dr. Tuomas Tammela
Tuomas Tammela, MD, PhD

The Tammela lab is interested in understanding the remarkable phenotypic heterogeneity of cancer cells within tumors. We approach this question using a combination of sophisticated genetically engineered mouse models, single cell transcriptomics, tracing and ablation of distinct tumor cell lineages, CRISPR-mediated gene regulation, and advanced imaging techniques. We utilize the exceptional resources developed by our MSK collaborators, such as organoids and xenografts, for the translation of our findings into new treatments for human cancer. Our goal is to discover pathways that drive distinct cellular phenotypes and to develop new therapeutic concepts aimed at reducing cellular heterogeneity in tumors.

Research Projects

Publications

Tammela T, Sanchez-Rivera FJ, Malli-Cetinbas N, Joshi NS, Helenius K, Park YK, Azimi R, Wu K, Kerper NR, Wesselhoeft RA, Gu X, Schmidt L, Cornwall-Brady M, Yilmaz ÖH, Xue W, Katajisto P, Bhutkar A, and Jacks T. A Wnt-producing niche maintains proliferative potential and drives tumor progression in lung adenocarcinoma. Nature, 545:355-359 (2017).

Roper J*, Tammela T*, Cetinbas N, Akkad A, Almeqdadi M, Wu K, Sánchez-Rivera F, Rickelt S, Park Y, Liang X, Oberli M, Eng G, Roghanian A, Azimi R, Kedrin D., Neupane R., Beyaz S., Sicinska E.T., Bass A., Suarez Y., Yoo J., Chen L., Taylor M.S., Zukerberg L., Katajisto P., Lees J., Deshpande V., Chen J., Hynes R.O., Langer R., Bhutkar A.J., Jacks T., Yilmaz. Ö.H. Epithelial genome editing and orthotopic transplantation models of sequential mutagenesis in colorectal cancer. Nature Biotechnology, 3:569–576 (2017).

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People

Dr. Tuomas Tammela

Tuomas Tammela, MD, PhD

  • Cancer biologist Tuomas Tammela investigates cellular heterogeneity in lung, pancreatic and colon cancers.
  • Massachusetts Institute of Technology: Postdoctoral Fellowship
  • University of Helsinki, Finland: MD, PhD

Members

Melissa Blum
Melissa Blum

Research Technician

Jason Chan, MD, PhD
Jason Chan

Clinical Fellow

Olivera Grbovic-Huezo, PhD Research Lab manager
Olivera Grbovic-Huezo

Research Lab manager

Anna Hudson
Anna Hudson

Research Technician

Emily B. Johnson, MPH
Emily B. Johnson

Administrative Assistant

Simon Joost
Simon Joost

Research Fellow

Zhuxuan Li
Zhuxuan Li
Ken Pitter
Ken Pitter

Clinical Fellow

Carleigh Sussman
Carleigh Sussman

Research Technician

Stefan Torborg
Stefan Torborg

MD-PhD Student

Yan Yan
Yan Yan

Postdoctoral Fellow

Xueqian Zhuang, PhD
Xueqian Zhuang

Postdoctoral Fellow

Lab Alumni
Alexander Ferrena
Alexander Ferrena

Computational Biology Laboratory Assistant

Griffin Hartmann, BS
Griffin Hartmann

Senior Research Technician

Katherine Wu, BS Senior Research Technician
Katherine Wu

Senior Research Technician

Lab Affilations

Achievements

  • NCI/NIH K99 Transition to Independence Award
  • European Research Council Starter Grant
  • Josie Robertson Young Investigator Award
  • The Werner Risau Prize

Open Positions

Career Opportunities

We are looking for highly motivated, talented, and enthusiastic scientists of all levels with an interest in addressing fundamental questions in cancer biology.

Apply now

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Tuomas Tammela discloses the following relationships and financial interests:

  • ACDbio/Bio-Techne
    Provision of Services
  • Gerson Lehrman Group
    Provision of Services
  • Regeneron Pharmaceuticals, Inc.
    Provision of Services
  • University of Helsinki
    Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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