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Scott Lowe
Cell Surface Protein uPAR May Hold the Key to Targeting Solid Tumors with CAR T Cell Therapy

MSK researchers and collaborators have developed a new type of CAR T cell designed to attack a cell surface protein called uPAR — allowing them to target both tumors and cancer-supporting cells in the tumor microenvironment.
Microscope in foreground, MSK researchers in the background.
MSK Research Highlights, March 27, 2026

New MSK research finds skin stem cells retain long-lasting memory of inflammation; shows how a large cancer DNA study could transform personalized oncology; reveals how the protein BAF helps cancer cells hide from the immune system; and investigates how early DNA markings shape cell fate.
a lab coat hangs in an MSK lab
MSK Research Highlights, March 20, 2026

New MSK research discovers a new approach that could prevent chemotherapy-related leukemia; shows how monoclonal antibodies can turn neutrophils into cancer killers; helps develop sensitive CAR T cells that target CD70 antigen to destroy cancer cells; and uses single-cell studies to yield new clues about a rare, aggressive pediatric sarcoma.
A researcher working in an MSK lab
MSK Research Highlights, March 2, 2026

New MSK research finds the TCA cycle’s waste-management function may present an opportunity against cancer; shows how microplastics impair immune ‘housekeeping’ functions; reveals the way the protein TOX plays different roles in different immune cells; and identifies a new combination approach for treating advanced kidney cancer after immunotherapy.
A researcher working in an MSK lab
MSK Research Highlights, February 23, 2026

New MSK research investigates harnessing the power of ferroptosis to spread cell death; reports how an MSK artificial intelligence (AI) model could help improve patient safety; and uses AI to reveal country-specific drivers of global cancer outcomes.
A researcher working in an MSK lab
MSK Research Highlights, February 4, 2026

New MSK research illuminates new details about Thetis cells that will support efforts to harness them therapeutically; shows how the timing and strength of danger signals steer immune cell fates; and employs single-nucleus DNA sequencing to shed new light on the evolution of pancreatic cancer.
fluorescent cells
Small Number of ‘Highly Plastic’ Cancer Cells Drive Disease Progression and Treatment Resistance

A small number of cancer cells with the ability to change their identities and behaviors appear to be a key driver of cancer progression and its ability to evolve resistance to treatment, MSK researchers have found in a laboratory study of lung cancer.
A researcher working in an MSK lab
MSK Research Highlights, January 20, 2026

New MSK research sheds new light on how the gut protects itself by sensing gut bacteria; finds a subtype of glioma-associated macrophages that appear to play a pivotal role in progression; and demonstrates that reduced surgery is an option for some thyroid cancer patients.
Cancer cells on a screen
Making Progress Against Metastasis

While there has been remarkable progress in the number of people surviving with stage 4 cancer, MSK remains dedicated to research that will spur much needed advances.
Scientific image showing spindle-shaped and round dormant metastatic cancer cells
Dormant Cancer Cells Change Shape To Survive Immune System Attack

New MSK research reveals how dormant metastatic cancer cells protect themselves from the immune system by changing their shape.