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VEXAS syndrome is a confounding adult-onset inflammatory disease first described in 2020, which affects 1 in 4,000 men over 50. Now, MSK researchers are shedding new light on its mechanisms and laying the groundwork for potential targeted treatments.
Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA replication and proceed without impairment to copy the chromosomes has proven naive. It is now clear that replication forks stall frequently as a result of encounters between the replication machinery and template damage, slow-moving or paused transcription complexes, unrelieved positive superhelical tension, covalent protein-DNA complexes, and as a result of cellular stress responses. These stalled forks are a major source of genome instability.
We are developing nanoscale sensors to detect cancer at its earliest stages. Using novel nanomaterials with unique optical properties, we are making it easier to identify disease biomarkers within the body, permitting detection before symptoms arise.
This information describes what urinary tract infections (UTIs) are and why you keep getting them. It describes risk factors, causes, and treatments for UTIs. It explains how you can prevent or stop them.
En esta información, se explica qué son las infecciones de las vías urinarias (UTI) y los motivos por los que las sigue teniendo. Se describen los factores de riesgo, las causas y los tratamientos para las UTI. También se explica qué puede hacer para prevenirlas o detenerlas.
Эта информация поможет вам понять, что такое инфекции мочевыводящих путей (urinary tract infections, UTI) и что является их причиной. В ней описаны факторы риска, причины и методы лечения UTI, а также приведены пояснения, как их можно предупредить или вылечить.