The Parada lab uses genetically engineered mouse models to recapitulate and study human disease. These mouse strains are used to understand the natural history of tumors of the nervous system, including glioblastoma multiforme (GBM), malignant peripheral nerve sheath tumors (MPNST), neurofibromas, and other diseases associated with neurofibromatosis (NF1). We seek to develop mouse cancer models based on concrete hypotheses and to rapidly transfer findings for validation in human cancer samples.
Luis F. Parada, PhD
Director, Brain Tumor Center; Albert C. Foster Chair; American Cancer Society Research Professor
Research FocusDevelopmental biologist Luis F. Parada uses genetically engineered mouse models to study neurofibromatosis, brain tumors, cancer stem cells, and tumor progression.
EducationPhD, Massachusetts Institute of Technology
- Sheila R. Alcantara Llaguno1, Zilai Wang1, Daochun Sun1, Jian Chen1, Jing Xu1, Euiseok Kim, Kimmo J. Hatanpaa, Jack M. Raisanen, Dennis K. Burns, Jane E. Johnson, Luis F. Parada1. Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes. Cancer Cell 2015; Volume 28, Issue 4; October 12, 2015; p.429-440.