Danilo Reynaldo Macalinao

Graduate Student

Danilo Macalinao

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Lab Phone





Joan Massagué

Start Year



BA, Wesleyan University

When I was about 6, my great-grandmother, who was a public-school science administrator, showed me a bird’s feather under a microscope. Seeing it up close was pretty spectacular and moving for me. Since then, I’ve been curious about understanding the many forces and phenomena around us that can’t readily be seen. The small community feel of the Gerstner Sloan Kettering program was a major factor in my decision to enter the program. The relatively small size of the student body facilitates developing more meaningful relationships with your peers. GSK students try to cultivate an environment where everyone looks out for each other.


Grayer Fellowship (2013-2014)

Robert B. Catell Fellowship (2012-2013)


Cross, S.H., Macalinao, D.G., McKie, L., Rose, L., Kearney, A.L., Rainger, J., Thaung, C., Keighren, M., Jadeja, S., West, K., et al. (2014). A Dominant-Negative Mutation of Mouse Lmx1b Causes Glaucoma and Is Semi-lethal via LBD1-Mediated Dimerisation. PLoS Genet 10, e1004359–15.

Howell, G.R., MacNicoll, K.H., Braine, C.E., Soto, I., Macalinao, D.G., Sousa, G.L., and John, S.W.M. (2014). Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma. Neurobiology of Disease 71, 44–52.

Reinholdt, L.G., Howell, G.R., Czechanski, A.M., Macalinao, D.G., MacNicoll, K.H., Lin, C.-S., Donahue, L.R., and John, S.W.M. (2012). Generating Embryonic Stem Cells from the Inbred Mouse Strain DBA/2J, a Model of Glaucoma and Other Complex Diseases. PLoS ONE 7, e50081–e50088.

Howell, G.R., Soto, I., Zhu, X., Ryan, M., Macalinao, D.G., Sousa, G.L., Caddle, L.B., MacNicoll, K.H., Barbay, J.M., Porciatti, V., et al. (2012). Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma. J. Clin. Invest. 122, 1246–1261.

Nair, K.S., Hmani-Aifa, M., Ali, Z., Kearney, A.L., Ben Salem, S., Macalinao, D.G., Cosma, I.M., Bouassida, W., Hakim, B., Benzina, Z., et al. (2011). Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nature Genetics 43, 579–584

Howell, G.R., Macalinao, D.G., Sousa, G.L., Walden, M., Soto, I., Kneeland, S.C., Barbay, J.M., King, B.L., Marchant, J.K., Hibbs, M., et al. (2011). Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J. Clin. Invest. 121, 1429–1444.