Inside My Lab: Joan Massagué

We are interested in metastasis, the cause 90% of cancer deaths. The lab investigates metastatic stem cells and their stromal niches. The role of immune regulatory and regenerative signals, particularly TGF-β, is of interest. General as well as organ-specific mediators of metastasis are under investigation. We are defining the phenotypic plasticity and evolution of metastatic cell populations from dormancy to outbreak, identifying drug targets, and enabling clinical trials to treat metastasis.

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Joan Massagué, PhD

Joan Massagué, PhD

Director, Sloan Kettering Institute; Member, Cancer Biology & Genetics Program


Research Focus

Joan Massagué studies the control of stem cell growth and phenotype in tumor progression, metastasis, and response to therapy.


PhD, University of Barcelona

Lab Members

  • Laughney, A.M., Hu, J., Campbell, N.R., Bakhoum, S.F.,Setty, M., Lavallée, V.-P., Xie, Y., Masilonis, I., Carr, A.J., Allaj, V., Mattar, M., Rekhtman, N., Xavier, J., Mazutis, L., Poirier, J.T., Rudin, C.M., Pe’er, D. and Massagué, J. Regenerative lineages and immune-mediated pruning in lung cancer metastasis. Nature Medicine 26, 259-269 (2020)
  • Su, J., M. Morgani, S.M., David, C.J., Wang, Q., Emrah Er, E.E., Huang, Y.-H., Basnet, H., Zou, Y., Shu, W., Hendrickson, R.C., Soni, R.K., Hadjantonakis, A.-K. and Massagué, J. TGF-β orchestrates fibrogenic and developmental EMTs via RAS effector RREB1. Nature 577, 566–571 (2020)
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Selected Achievements
  • Director, Sloan Kettering Institute (2014–)
  • HHMI Scientific Review Board (2014–)
  • HHMI Investigator (1990-2013)
  • Fellow, American Association for Cancer Research (AACR) Academy (2016)
  • Pezcoller Foundation-AACR International Award for Cancer Research (2016)
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  • Charles Rodolphe Brupbacher Prize for Cancer Research (2015)
  • National Prize for Research in Biology, Spain (2014)
  • American Italian Cancer Foundation Price (2013)
  • Prize in Cancer Research, Robert J. and Claire Pasarow Foundation (2011)
  • Frontiers Prize in Biomedicine, BBVA Foundation (2008)
  • Vilcek Prize, Vilcek Foundation (2006)
  • Member, Institute of Medicine (2006)
  • Award in Science and Technology, Prince Asturius Foundation (2004)
  • Member, National Academy of Sciences (2000)
  • Member, American Academy of Arts and Sciences (1999)
  • Investigator, Howard Hughes Medical Institute (1990)
  • Elucidation of the TGF-beta pathway