Omar Abdel-Wahab is an Assistant Member in the Human Oncology and Pathogenesis Program (HOPP) and an Attending Physician on the Leukemia Service in the Department of Medicine at Memorial Sloan Kettering Cancer Center. Dr. Abdel-Wahab’s research focuses on the role of disordered epigenetic modifiers in the pathogenesis of hematopoietic malignancies.
Omar Abdel-Wahab, MD
Associate Professor
Research Focus
Physician-scientist Omar Abdel-Wahab studies the functional genomics of hematopoietic malignancies.Education
MD, Duke University School of MedicineLab Members
Hana Cho
Research Technician
Benjamin Durham
Research Fellow
Daichi Inoue
Research Fellow
Stanley Lee
Research Fellow
Bo Liu
Research Fellow
Justin Taylor
Fellow
Akihide Yoshimi
Research Fellow
Publications
- Taylor J, Pavlick D, Yoshimi A, Marcelus C, Chung SS, Hechtman JF, Benayed R, Cocco E, Durham BH, Bitner L, Inoue D, Chung YR, Mullaney K, Watts JM, Diamond EL, Albacker LA, Mughal TI, Ebata K, Tuch BB, Ku N, Scaltriti M, Roshal M, Arcila M, Ali S, Hyman DM, Park JH, Abdel-Wahab O. Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies. J Clin Invest. 2018 Aug
31;128(9):3819-3825. doi: 10.1172/JCI120787. Epub 2018 Aug 6. PubMed - Lee SC, North K, Kim E, Jang E, Obeng E, Lu SX, Liu B, Inoue D, Yoshimi A, Ki M, Yeo M, Zhang XJ,Kim MK, Cho H, Chung YR, Taylor J, Durham BH, Kim YJ, Pastore A, Monette S, Palacino J, Seiler M, Buonamici S, Smith PG, Ebert BL, Bradley RK, Abdel-Wahab O. Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations. Cancer Cell. 2018 Aug
13;34(2):225-241.e8. doi: 10.1016/j.ccell.2018.07.003. PubMed [PMID: 30107174]
Hoyos LE, Abdel-Wahab O. Cancer-Specific Splicing Changes and the Potential for Splicing-Derived Neoantigens. Cancer Cell. 2018 Aug 13;34(2):181-183. doi: 10.1016/j.ccell.2018.07.008. PubMed [PMID: 30107172]
Gala K, Li Q, Sinha A, Razavi P, Dorso M, Sanchez-Vega F, Chung YR, Hendrickson R, Hsieh JJ, Berger M, Schultz N, Pastore A, Abdel-Wahab O, Chandarlapaty S. KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function. Oncogene. 2018 Aug;37(34):4692-4710. doi: 10.1038/s41388-018-0273-5. Epub 2018 May 14. PubMed Central PMCID: PMC6107480. PubMed
Selected Achievements
- Seldin-Smith Award for Pioneering Research, American Society of Clinical Investigation
- Pershing Square Sohn Prize for Young Investigators in Cancer Research
- Leukemia & Lymphoma Society Clinical Scholar Award
- Joanne Levy Memorial Award for Outstanding Achievement, American Society of Hematology
- V Scholar Award, V Foundation
