Human Oncology & Pathogenesis Program

The Omar Abdel-Wahab Lab

Research

Omar Abdel-Wahab, MD

Member, Human Oncology and Pathogenesis Program; Attending Physician, Leukemia Service; Director, MSK Center for Hematologic Malignancies

Omar Abdel-Wahab is a Member in Human Oncology and Pathogenesis Program (HOPP), an Attending Physician on the Leukemia Service in the Department of Medicine at Memorial Sloan Kettering Cancer Center, and the Director of Memorial Sloan Kettering’s Center for Hematologic Malignancies. Dr. Abdel-Wahab’s research focuses on the role of genomic alterations in the pathogenesis of hematopoietic malignancies.

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Featured News

In the Lab

Scientists Find Cancer Drivers Hiding in a New Place

Monday, August 27, 2018

In the Lab

Splicing May Be an Effective Target in the Fight against Cancer

Wednesday, July 18, 2018

Feature

What Is Epigenetics, and Why Is Everyone Talking about It?

Tuesday, June 19, 2018

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Publications

Lu SX, De Neef E, Thomas JD, Sabio E, Rousseau B, Gigoux M, Knorr DA, Greenbaum B, Elhanati Y, Hogg SJ, Chow A, Ghosh A, Xie A, Zamarin D, Cui D, Erickson C, Singer M, Cho H, Wang E, Lu B, Durham BH, Shah H, Chowell D, Gabel AM, Shen Y, Liu J, Jin J, Rhodes MC, Taylor RE, Molina H, Wolchok JD, Merghoub T, Diaz LA Jr, Abdel-Wahab O (co-corresponding; Lead Contact), Bradley RK (co-corresponding). Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell. 2021 Jun 18:S0092-8674(21)00690-5. doi: 10.1016/j.cell.2021.05.038. Epub ahead of print. PMID: 34171309.

Inoue D, Polaski JT, Taylor J, Castel P, Chen S, Kobayashi S, Hogg SJ, Hayashi Y, Pineda JMB, El Marabti E, Erickson C, Knorr K, Fukumoto M, Yamazaki H, Tanaka A, Fukui C, Lu SX, Durham BH, Liu B, Wang E, Mehta S, Zakheim D, Garippa R, Penson A, Chew GL, McCormick F, Bradley RK, Abdel-Wahab O. Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nat Genet. 2021 Apr 12. doi: 10.1038/s41588-021-00828-9. Epub ahead of print. PMID: 33846634.

Taylor J, Donoghue MT, Ho C, Petrova-Drus K, Al-Ahmadie HA, Funt SA, Zhang Y, Aypar U, Rao P, Chavan SS, Haddadin M, Tamari R, Giralt S, Tallman MS, Rampal RK, Baez P, Kappagantula R, Kosuri S, Dogan A, Tickoo SK, Reuter VE, Bosl GJ, Iacobuzio-Donahue CA, Solit DB, Taylor BS, Feldman DR, Abdel-Wahab O. Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor. J Clin Invest. 2020 Dec 1;130(12):6668-6676. doi: 10.1172/JCI139682. PMID: 32897884; PMCID: PMC7685753.

Taylor J, Mi X, North KD, Binder M, Penson A, Lasho TL, Knorr K, Haddadin M, Liu B, Pangallo J, Benbarche S, Wiseman DH, Tefferi A, Halene S, Liang Y, Patnaik MM, Bradley RK, Abdel-Wahab O. Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms. Blood. 2020 Jul 8:blood.2020006868. doi: 10.1182/blood.2020006868. Epub ahead of print. PMID: 32640014

Yoshimi A, Lin KT, Wiseman DH, Rahman MA, Pastore A, Wang B, Lee SC, Micol JB, Zhang XJ, de Botton S, Penard-Lacronique V, Stein EM, Cho H, Miles RE, Inoue D, Albrecht TR, Somervaille TCP, Batta K, Amaral F, Simeoni F, Wilks DP, Cargo C, Intlekofer AM, Levine RL, Dvinge H, Bradley RK, Wagner EJ, Krainer AR, Abdel-Wahab O. Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis. Nature. 2019 Oct;574(7777):273-277. doi: 10.1038/s41586-019-1618-0. Epub 2019 Oct 2. PMCID: PMC6858560.

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People

Omar Abdel-Wahab, MD

Member, Human Oncology and Pathogenesis Program; Attending Physician, Leukemia Service; Director, MSK Center for Hematologic Malignancies

Physician-scientist Omar Abdel-Wahab studies the functional genomics of hematopoietic malignancies.
MD, Duke University School of Medicine

abdelwao@mskcc.org: Email Address
View physician profile: Physician profile

Members

Ha Na Cho, Research Assistant — Hana Cho
Research Assistant

Benjamin Durham, Instructor (Pathology) — Benjamin Durham
Instructor (Pathology)

Won Kim

Graduate Student

Bo Liu, Research Associate — Bo Liu
Research Associate

Bin Lu, Research Associate — Bin Lu
Research Associate

Sydney Lu, Research Fellow — Sydney Lu
Assistant Member, Myeloma Service

Erich Sabio

Senior Research Scientist

Lab Alumni

Lillian Bitner, Research Technician — Lillian Bitner
Research Technician

Luisa Escobar Hoyos

Research Fellow

Monisha Hosier
Administrative Assistant II

Daichi Inoue, Visiting Investigator — Daichi Inoue
Visiting Investigator

Pictured: Stanley Lee — Stanley Lee
Research Associate

Alessandro Pastore, Senior Research Scientist — Alessandro Pastore
Senior Research Scientist

Alexander Penson, PhD — Alexander Penson
Senior Computational Biologist

Justin Taylor

Instructor (Dept. of Medicine)

Akihide Yoshimi, Senior Research Scientist — Akihide Yoshimi
Senior Research Scientist

Xiao Zhang

Lab Affiliations

Achievements

Josie Robertson Investigator (2012-2017)
Seldin-Smith Award for Pioneering Research, American Society of Clinical Investigation
Pershing Square Sohn Prize for Young Investigators in Cancer Research
Leukemia & Lymphoma Society Clinical Scholar Award
Joanne Levy Memorial Award for Outstanding Achievement, American Society of Hematology

V Scholar Award, V Foundation
Junior Faculty Scholar Award, American Society of Hematology (ASH)
Damon Runyon Clinical Investigator Award

Get in Touch

abdelwao@mskcc.org

Lab Head Email

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Omar Abdel-Wahab discloses the following relationships and financial interests:

AIchemy, Inc.
Ownership / Equity Interests; Provision of Services (uncompensated)
Envisagenics
Ownership / Equity Interests; Provision of Services (uncompensated)

Epizyme
Intellectual Property Rights
Janssen Global Services, LLC
Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

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