Our research is focused on understanding the molecular mechanisms governing the differentiation and function of CD4 T lymphocytes and their role in immunity and tolerance. Major areas of interest include: the molecular and cellular mechanisms governing the differentiation and function of regulatory T cells; the roles these cells play in control of autoimmunity, tumor immunity, and immunity to infections, and in the maintenance of immune homeostasis at environmental interfaces. We are particularly interested in understanding the role of the forkhead family transcription factor Foxp3 in establishing and maintaining immune homeostasis; and in the plasticity of regulatory T cell transcriptional and functional programs and the molecular mechanisms of regulatory T cell lineage stability.
Alexander Rudensky, PhD
Chair, Immunology Program, SKI; Director, Ludwig Center at MSK
Professor
Research Focus
Immunology Program Chair Alexander Rudensky focuses on immunological tolerance and the differentiation and function of T cells.Education
PhD, Gabrichevsky Institute for Microbiology and Epidemiology- Office Phone: 646-888-3109
- Office Fax: 646-422-0453
Lab Members
Assistant Attending, Breast Service
Graduate Student
Graduate Student
Research Associate
Associate Attending, Gastric & Mixed Tumor Service
Graduate Student
Research Fellow
MD-PhD student
Graduate Student
Research Fellow
Graduate Student
Technician
Graduate Student
Research Fellow
Visiting Investigator
Senior Research Scientist
Research Fellow
Research Associate
Research Fellow
Graduate Student
Bioinformatics Analyst
Research Fellow, Department of Surgery
Technician
Graduate Student
Research Fellow
Publications
- Levine AG, Mendoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, Hoyos BE, Putintseva EV, Chaudhry A, Dikiy S, Fujisawa S, Chudakov DM, Treuting PM,Rudensky AY. (2017) Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 546:421-425.
- van der Veeken J, Gonzalez AJ, Cho H, Arvey A, Hemmers S, Leslie CS, Rudensky AY. (2016) Memory of Inflammation in Regulatory T Cells. Cell.166:977-990.
Selected Achievements
- Investigator, Howard Hughes Medical Institute
- Vilcek Prize in Biomedical Science, New York, NY (2018)
- Crafoord Prize, the Royal Swedish Academy of Sciences, Stockholm Sweden (2017)
- Member, National Academy of Medicine (2015)
- Member, American Academy of Arts and Sciences (2015)
- Coley Award in Basic Immunology, Cancer Research Institute (2015)
- Thomson Reuters Citation Laureate (2015)
- Member, National Academy of Sciences (2012)
- Merit Award, National Institutes of Health (2009)
- Investigator Award, American Association of Immunologists/PharMingen (1999)
- Searle Scholar Award (1993)
- Investigator, Howard Hughes Medical Institute (1993)
- Elucidation of the function of transcription factor Foxp3 in regulatory T cells and their critical role in immune homeostasis (2003-2010)
- Identification of the primary structure of MHC class II bound peptides (1991)
