Our research is focused on understanding the molecular mechanisms governing the differentiation and function of CD4 T lymphocytes and their role in immunity and tolerance. Major areas of interest include: the molecular and cellular mechanisms governing the differentiation and function of regulatory T cells; the roles these cells play in control of autoimmunity, tumor immunity, and immunity to infections, and in the maintenance of immune homeostasis at environmental interfaces. We are particularly interested in understanding the role of the forkhead family transcription factor Foxp3 in establishing and maintaining immune homeostasis; and in the plasticity of regulatory T cell transcriptional and functional programs and the molecular mechanisms of regulatory T cell lineage stability.
Alexander Rudensky, PhD
Chair, Immunology Program, SKI; Director, Ludwig Center at MSK
Professor
Research Focus
Immunology Program Chair Alexander Rudensky focuses on immunological tolerance and the differentiation and function of T cells.Education
PhD, Gabrichevsky Institute for Microbiology and Epidemiology- Office Phone: 646-888-3109
- Office Fax: 646-422-0453
Lab Members
George Plitas
Assistant Attending, Breast Service
Joris van der Veeken
Graduate Student
Clarissa Campbell Menezes
Graduate Student
Saskia Hemmers
Research Associate
Bruno Moltedo
Research Associate
Charlotte Ariyan
Associate Attending, Gastric & Mixed Tumor Service
Chrysothemis Brown
Research Fellow
Stanislav Dikiy
Graduate Student
Xiying Fan
MD-PhD Student
Rachel Fromme
Technician
Ariella Glasner
Research Fellow
Beatrice Hoyos
Visiting Investigator
Jing Ping Hsin
Research Fellow
Wei Hu
Research Fellow
Catherine Konopacki
Graduate Student
Peter McKenney
Research Associate
Alejandra Mendoza
Research Fellow
Michael Schizas
Bioinformatics Analyst
Jacob Verter
Technician
Zhongmin Wang
Graduate Student
Yi Zhong
Research Fellow
Publications
- Levine AG, Mendoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, Hoyos BE, Putintseva EV, Chaudhry A, Dikiy S, Fujisawa S, Chudakov DM, Treuting PM,Rudensky AY. (2017) Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 546:421-425.
- van der Veeken J, Gonzalez AJ, Cho H, Arvey A, Hemmers S, Leslie CS, Rudensky AY. (2016) Memory of Inflammation in Regulatory T Cells. Cell.166:977-990
Selected Achievements
- Investigator, Howard Hughes Medical Institute
- Vilcek Prize in Biomedical Science, New York, NY (2018)
- Crafoord Prize, the Royal Swedish Academy of Sciences, Stockholm Sweden (2017)
- Member, National Academy of Medicine (2015)
- Member, American Academy of Arts and Sciences (2015)
