Immunology is one of the most fruitful areas of contemporary biomedical science. Insights from immunology have infused medicine with a renewed sense of optimism about the treatment of many stubborn diseases, such as cancer and autoimmunity.
SKI’s Immunology Program is broad in scope and comprises both basic and translational research. Our scientists are world leaders in the study of innate and adaptive immunity, host-microbiota interactions, and mechanisms of immune regulation.
A strength of the program is the ability to translate laboratory findings into effective clinical applications. Scientists from our program have played a central role in the development of several types of immunotherapy that are currently transforming cancer care, including checkpoint blockade and CAR T cell therapy.
Research in the Immunology Program focuses on several areas:
- cell signaling
- development in the thymus
- T cell selection
- antigen processing and presentation
- genetic approaches to transplantation and active immunization
- cancer immunology
- infection and immunity
- transplantation immunology
- adoptive cellular therapies including CAR therapy
- Richard J. O'Reilly, MD
Physician-scientist Richard O’Reilly investigates the genetic disparities and cellular interactions between donor and host that affect allogeneic hematopoietic cell transplantation.
- Justin Perry, PhD
Immunologist Justin Perry investigates homeostatic apoptotic cell clearance and how this process is exploited during cancer development and progression.
- Michel Sadelain, MD, PhD
Immunologist Michel Sadelain studies the mechanisms governing transgene expression, stem cell engineering, and genetic strategies to enhance immunity against cancer.
- Andrea Schietinger, PhD
Cancer Immunologist Andrea Schietinger investigates immune responses to cancer, molecular mechanisms underlying tumor-induced T cell dysfunction, and new approaches for cancer immunotherapy.
- Joseph Sun, PhD
Immunologist Joseph Sun investigates the natural killer cell response against infection and cancer.
- Marcel R. M. van den Brink, MD, PhD
Physician-scientist Marcel R. M. van den Brink studies the immunology of bone marrow transplantation with a particular focus on intestinal microbiome and strategies to enhance thymus and immune reconstitution
- Jedd D. Wolchok, MD, PhD, FASCO
Physician-scientist Jedd Wolchok investigates novel approaches for cancer immunotherapy and mechanisms of tumor cell–immune cell interactions. He has been at the forefront of cancer immunotherapy, as an active clinician scientist exploring innovative immunotherapeutic strategies in laboratory models and as a principal investigator in numerous pivotal clinical trials.
- James W. Young, MD
Physician-scientist James Young studies innate and adaptive immunity against tumors and viruses stimulated by human dendritic cells.
Collaborations & Resources
SKI offers a wide array of core facilities and other technologies, as well as significant opportunity for collaboration. Members of the Immunology Program derive particular benefit from close ties to the following: