Research Programs

Immunology Program

Immunology is one of the most fruitful areas of contemporary biomedical science. Insights from immunology have infused medicine with a renewed sense of optimism about the treatment of many stubborn diseases, such as cancer and autoimmunity.

SKI’s Immunology Program is broad in scope and comprises both basic and translational research. Our scientists are world leaders in the study of innate and adaptive immunity, host-microbiota interactions, and mechanisms of immune regulation. 

A strength of the program is the ability to translate laboratory findings into effective clinical applications. Scientists from our program have played a central role in the development of several types of immunotherapy that are currently transforming cancer care, including checkpoint blockade and CAR T cell therapy.

Research in the Immunology Program focuses on several areas:

  • cell signaling
  • development in the thymus
  • T cell selection
  • antigen processing and presentation
  • genetic approaches to transplantation and active immunization
  • cancer immunology
  • infection and immunity
  • transplantation immunology
  • adoptive cellular therapies including CAR therapy
Immunology Program Chair Sasha Rudensky with Dana Pe'er, Chair of the Computational & Systems Biology Program.

Immunology Program Chair Sasha Rudensky with frequent collaborator Dana Pe’er, Chair of the Computational & Systems Biology Program.

Our Faculty

  • Alexander Rudensky, PhD
    Chair, Immunology Program
    Immunology Program Chair Alexander Rudensky focuses on immunological tolerance and the differentiation and function of T cells.
  • Jayanta Chaudhuri, PhD
    Immunologist Jayanta Chaudhuri studies the mechanisms of immunoglobulin gene diversification.
  • Frederic Geissmann, MD, PhD
    My research is focused on cellular and molecular mechanisms that control the differentiation, maintenance, and physiological functions of macrophages and monocytes and their roles in tissue homeostasis and disease processes.
  • Michael S. Glickman, MD
    Physician-scientist Michael Glickman investigates the physiology and pathogenic mechanisms of mycobacteria, including regulated intramembrane proteolysis (the Rip1 pathway); double-strand-break repair and associated DNA damage responses; and cell envelope biosynthesis.
  • Alan Houghton, MD
    Cancer immunologist Alan Houghton studies the immune response to cancer, immune recognition of self and mutated molecules, and development of new immunotherapies.
  • Morgan Huse, PhD
    Immunologist Morgan Huse studies the structure and function of immune cell-cell interactions.
  • Ming Li, PhD
    Immunologist Ming Li studies mechanisms of immune regulation, and their relevance to diseases including cancer.
  • Richard J. O'Reilly, MD
    Physician-scientist Richard O’Reilly investigates the genetic disparities and cellular interactions between donor and host that affect allogeneic hematopoietic cell transplantation.
  • Justin Perry, PhD
    Immunologist Justin Perry investigates homeostatic apoptotic cell clearance and how this process is exploited during cancer development and progression.
  • Michel Sadelain, MD, PhD
    Immunologist Michel Sadelain studies the mechanisms governing transgene expression, stem cell engineering, and genetic strategies to enhance immunity against cancer.
  • Andrea Schietinger, PhD
    Cancer Immunologist Andrea Schietinger investigates immune responses to cancer, molecular mechanisms underlying tumor-induced T cell dysfunction, and new approaches for cancer immunotherapy.
  • Joseph Sun, PhD
    Immunologist Joseph Sun investigates the natural killer cell response against infection and cancer.
  • Marcel R. M. van den Brink, MD, PhD
    Physician-scientist Marcel R. M. van den Brink studies the immunology of bone marrow transplantation with a particular focus on intestinal microbiome and strategies to enhance thymus and immune reconstitution

Joint Appointees

  • Tobias M. Hohl, MD, PhD
    Physician-scientist Tobias Hohl studies the molecular pathogenesis of human fungal pathogens and how the immune system responds to them.
  • Katharine C. Hsu, MD, PhD
    Physician-scientist Katharine Hsu studies the biology of human natural killer cells and how they contribute to disease processes.
  • Jedd D. Wolchok, MD, PhD, FASCO
    Physician-scientist Jedd Wolchok investigates novel approaches for cancer immunotherapy and mechanisms of tumor cell–immune cell interactions. He has been at the forefront of cancer immunotherapy, as an active clinician scientist exploring innovative immunotherapeutic strategies in laboratory models and as a principal investigator in numerous pivotal clinical trials.
  • James W. Young, MD
    Physician-scientist James Young studies innate and adaptive immunity against tumors and viruses stimulated by human dendritic cells.

Collaborations & Resources

SKI offers a wide array of core facilities and other technologies, as well as significant opportunity for collaboration. Members of the Immunology Program derive particular benefit from close ties to the following:

Join Our Program
We seek out innovative new scientists to join our faculty on an annual basis. Recruitment begins in the fall. Postdocs and other prospective lab members can learn more by browsing the lab pages of individual PIs or by visiting our Careers website.
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Latest News

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Seminars & Events

View events and symposia sponsored by the Immunology Program.