Structural Biology Program
The Christopher Lima Lab
We are a basic research laboratory that studies the structural, biochemical, and functional basis for macromolecules involved in post-translational protein modification by ubiquitin and ubiquitin-like proteins such as SUMO, and pathways that contribute to co- and post-transcriptional RNA maturation, processing and decay. We pursue biochemical approaches to reconstitute key intermediates or complexes in these pathways and combine them with single particle cryo-EM and x-ray crystallography in conjunction with genetics and biochemistry to elucidate structure/activity relationships.
Das, M., Zattas, D., Zinder, J.C., Wasmuth, E.V., Henri, J., Lima, C.D. Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome. Proc Natl Acad Sci U S A. 118:e2024846118. (2021) [PMID: 33782132]
Hann, Z.S., Ji, C., Olsen, S.K., Lu, X., Lux, M.C., Tan, D.S., Lima, C.D.Structural basis for adenylation and thioester bond formation in the ubiquitin E1. Proc Natl Acad Sci U S A. 116, 15475-15484. (2019) [PMID: 31235585]
Weick, E.M., Puno, M.R., Januszyk, K., Zinder, J.C., DiMattia, M.A., Lima, C.D. Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex. Cell 173, 1663-1677 (2018) [PMID: 29906447]
Christopher D. Lima, PhD
Chair, Structural Biology Program, SKI
- The Lima laboratory studies mechanisms underlying RNA processing as well as post-translational protein modification by ubiquitin-like proteins.
- PhD, Northwestern University
- Member, National Academy of Sciences (2020)
- Fellow of the American Academy of Arts and Sciences (2017)
- Investigator, Howard Hughes Medical Institute (2013)
- Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2006)
- Scholar, Rita Allen Foundation (2003-2006)
- Mayor's Award for Excellence in Science and Technology, NYC Department of Cultural Affairs and New York Academy of Sciences (2003)
- Young Investigator Award, Arnold and Mabel Beckman Foundation (1999-2002)
Applicants who are interested in working on mechanisms involved in post-translational protein modification or RNA capping and decay processes are always encouraged to apply for Postdoctoral Fellow positions in the lab.
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Christopher D. Lima discloses the following relationships and financial interests:
Ownership / Equity Interests
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