The Lima Lab

We are a basic research laboratory that studies the structural, biochemical, and functional basis for macromolecules involved in post-translational protein modification by ubiquitin and ubiquitin-like proteins such as SUMO, and pathways that contribute to co- and post-transcriptional RNA maturation, processing and decay. We pursue biochemical approaches to reconstitute key intermediates or complexes in these pathways and combine them with single particle cryo-EM and x-ray crystallography in conjunction with genetics and biochemistry to elucidate structure/activity relationships.

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Pictured: Christopher Lima

Christopher D. Lima, PhD

Chair, Structural Biology Program, SKI


Research Focus

The Lima laboratory studies mechanisms underlying RNA processing as well as post-translational protein modification by ubiquitin-like proteins.


PhD, Northwestern University

Lab Members

Selected Achievements
  • Member, National Academy of Sciences (2020) 
  • Fellow of the American Academy of Arts and Sciences (2017)
  • Investigator, Howard Hughes Medical Institute (2013)
  • Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2006)
  • Scholar, Rita Allen Foundation (2003-2006)
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  • Mayor's Award for Excellence in Science and Technology, NYC Department of Cultural Affairs and New York Academy of Sciences (2003)
  • Young Investigator Award, Arnold and Mabel Beckman Foundation (1999-2002)