Journal Club 2020

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12/11/2020 - presented by Zaki Molvi

T cells exhibit unexpectedly low discriminatory power and can respond to ultra-low affinity peptide-MHC ligands.”

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11/13/2020 - presented by Mamadou Bah

TGF-β suppresses type 2 immunity to cancer.”

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11/06/2020 - presented by Keifer Kurtz

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19.”

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10/23/2020 - presented by Zita Aretz

Biogenesis of HLA Ligand Presentation in Immune Cells Upon Activation Reveals Changes in Peptide Length Preference.”

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10/16/2020 - presented by Heather Jones

Metabolic engineering generates a transgene-free safety switch for cell therapy.”

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10/09/2020 - presented by Kristen Vogt

Specific MHC-I Peptides Are Induced Using PROTACs.

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9/17/2020 - presented by Leila Peraro

Engineered off-the-shelf therapeutic T cells resist host immune rejection.”

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7/10/2020 - presented by Manish Malviya

ß-cell–mimetic designer cells provide closed-loop glycemic control.”

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6/26/2020 - presented by Zaki Molvi

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection.”

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“An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations.”

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5/29/2020 - presented by Leila Peraro

Nitinol thin films functionalized with CAR-T cells for the treatment of solid tumours.”

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5/08/2020 - presented by Pedro Silberman

Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies”

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4/25/2020 - presented by Kiefer Kurtz

Long-distance modulation of bystander tumor cells by CD8+ T-cell-secreted IFN-γ.”

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4/17/2020 - presented by Kristen Vogt

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors.”

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4/10/2020 - presented by Zaki Molvi

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease.”

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4/03/2020 - presented by Megan Dacek

DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade.”

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3/20/2020 - presented by Heather Jones

“Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses.”

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2/14/2020 - presented by Manish Malviya

“Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade”

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2/07/2020 - presented by Leila Peraro

Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1.”

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1/31/2020 - presented by Megan Dacek

Targeted deletion of PD-1 in myeloid cells induces antitumor immunity.”

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1/24/2020 - presented by Thomas Gardner

A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo.”

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