Molecular Pharmacology Program
The David Scheinberg Lab
Research
The overall goals of this laboratory are to develop novel targeted immunotherapies based on effectors of the immune system and to understand their mechanisms of action as well as the mechanisms of resistance to them. This includes antibodies, targeted nano-devices, engineered cells, and active specific agents such vaccines. An important goal is to take these new therapies into human clinical trials for testing. Examples include a molecular nanogenerator that releases alpha particles inside cancer cells, now being tested in Phase II human trials and a vaccine to WT1 about to enter Phase III trials. Read full article in Science. A WT1 vaccine is also in late stage national trials (Blood, 2010).
We have developed targeted alpha particle therapies, targeted beta emitters, oncogenic protein peptide vaccines, humanized antibodies, each of which reached human clinical trials; More recently we have discovered TCR mimic antibodies to intracellular proteins (Science Trans. Med., 2013), (Nature Biotech., 2015), as well as prototype targeted nano-machines (Nature Nano, 2013).
Research Projects
Featured News
People
David A. Scheinberg, MD, PhD
Chair, Molecular Pharmacology Program, SKI; Director, Center for Experimental Therapeutics, MSK
- Molecular Pharmacology Program Chair David Scheinberg focuses on the discovery and development of novel, specific immunotherapeutic agents and targeted nanodevices for cancer therapy.
- MD, PhD, Johns Hopkins University School of Medicine
- scheinbd@mskcc.org
- Email Address
- 646-888-2190
- Office Phone
- View physician profile
- Physician profile
Members
Senior Research Technician
Senior Research Scientist
Senior Research Technician
Member and Attending
Member
Graduate Student
Research Technician
Graduate Student
Research Technician
Graduate Student
Research Fellow
Senior Research Technician
Research Scholar
Graduate Student
Lab Alumni
Associate Medical Director at ApotheCom, San Francisco, CA
Graduate Student
Research Fellow
Graduate Student
Graduate Student
Visiting Scientist
Graduate Student
Research Technician
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Research Technician
Research Technician
Research Technician
Research Fellow
Lab Affilations
- Molecular Pharmacology Program
- Department of Medicine
- Center for Experimental Therapeutics
- Center for Cell Engineering
- Geoffrey Beene Cancer Research Center
- Center for Molecular Imaging & Nanotechnology
- Tri-Institutional PhD Program in Chemical Biology
- Gerstner Sloan Kettering Graduate School of Biomedical Sciences
