Research in our laboratory aims to characterize the molecular mechanisms underlying cell-to-cell interactions and signal transduction across the cell membrane. We are particularly interested in understanding how receptors located on the surface of developing axons and neurons interact with extracellular ligands to guide the development of the nervous system and the wiring of the brain.
Dimitar B. Nikolov, PhD
Professor
Research Focus
Structural biologist Dimitar Nikolov focuses on the structural, biophysical, and biochemical characterization of the molecular mechanisms of cell-cell interactions and signal transduction in the nervous system.Education
PhD, The Rockefeller University- Office Phone: 212-639-6784
- Lab Phone: 212-639-6837 / 6806
- Lab Fax: 212-717-3135
Lab Members
Dimitar B. Nikolov
Member
Juha Himanen
Senior Research Scientist
Alexander Antipenko
Senior Research Scientist
Nayanendu Saha
Senior Research Scientist
Kai Xu
Research Associate
Momchil Kolev
Research Assistant
Dorothea Robev
Research Assistant and Laboratory Manager
Maria Minchenko
Graduate Student
David Grandy
Graduate Student
Emilia Mason
Postdoctoral Research Scholar
Publications
- Xu K, Wu Z, Renier N, Antipenko A, Tzvetkova-Robev D, Xu Y, Minchenko M, Nardi-Dei V, Rajashankar KR, Himanen J, Tessier-Lavigne M, Nikolov DB., Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism., Science. (2014), May 29, pii: 1255149. [Epub ahead of print]
- Barton WA, Dalton AC, Seegar TC, Himanen JP, and Nikolov DB, Tie2 and Eph Receptor Tyrosine Kinase Activation and Signaling, Cold Spring Harbor Perspectives in Biology: “Signaling by Receptor Tyrosine Kinases” edited by Joseph Schlessinger and Mark A. Lemmon, Cold Spring Harbor Laboratory Press, ISBN978-1-936113-33-0, pages 287-303, (2014).
