Kim S, Chung J, Arlt H, Pak AJ, Farese RV Jr, Walther TC, Voth G. (2022) Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane. Elife. 11:e75808.

Song J, Mizrak A, Lee CW, Cicconet M, Lai ZW, Lu CH, Mohr SE, Farese RV Jr**, Walther TC**. (2022). Identification of two pathways mediating protein targeting from ER to lipid droplets. Nat Cell Biol. 24(9):1364-1377.

Boland, S. Swarup S, Ambaw Y.A, Richards R.C, Fischer A.W, Singh S. Aggarwal G, Spina S, Nana A.L, Grinberg L.T, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC**, Farese RV Jr.** (2021) Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat Comm (in press).

Farese RV Jr, Walther TC. (2022) Glycerolipid synthesis and lipid droplet formation in the endoplasmic reticulum. Cold Spring Harb Perspect Biol. Sep 12:a041246. doi: 10.1101/cshperspect.a041246. Online ahead of print

Arlt H, Sui X, Folger B., Adams C, Chen X, Remme R, Hamprecht F.A, DiMaio F, Liao M, Goodman J.M, Farese RV Jr**, Walther TC**. (2021) Seipin forms a flexible cage at lipid droplet formation sites. Nat Struct Mol Biol. 29(3): 194-202.

Olarte MJ, Swanson JMJ, Walther TC**, Farese RV Jr.** (2021) The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting. Trends Biochem Sci. Sep 25:S0968-0004(21)00187-0. doi: 10.1016/j.tibs.2021.08.007. Epub ahead of print. PMID: 34583871.

Mejhert N, Kuruvilla L, Gabriel KR, Elliott SD, Guie MA, Wang H, Lai ZW, Lane EA, Christiano R, Danial NN, Farese RV Jr**, Walther TC** (2020) Partitioning of MLX-Family transcription factors to lipid droplets regulates metabolic gene expression. Mol Cell. Mar 19;77 (6): 1251-1264.e9.

Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ, Bronson RT, Harper JW, Farese RV Jr**, Walther TC**. (2020) Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration. Proc Natl Acad Sci USA. 117(19):10565-10574.

Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC**, Farese RV Jr**. (2020) Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature. 581(7808):323-328.

Olarte MJ, Kim S, Sharp ME, Swanson JMJ, Farese RV Jr**, Walther TC**. (2020) Determinants of endoplasmic reticulum-to-lipid droplet protein targeting. Dev Cell. 54(4):471-487.e7.

Becuwe M, Bond LM, Pinto AFM, Boland S, Mejhert N, Elliott SD, Cicconet M, Graham MM, Liu XN, Ilkayeva O, Saghatelian A, Walther TC**, Farese RV Jr**. (2020) FIT2 Is an acyl-coenzyme a diphosphatase crucial for endoplasmic reticulum homeostasis. J Cell Biol. 219(10):e202006111.

Chitraju C, Fischer AW, Farese RV Jr**, Walther TC**. (2020) Lipid droplets in brown adipose tissue are dispensible for cold-induced thermogenesis. Cell Rep. 33(5):108348.

Christiano R*, Arlt H*, Kabatnik S, Mejhert N, Lai ZW, Farese RV Jr**, Walther TC**. (2020) A systematic protein turnover map for decoding protein degradation. Cell Rep. 33(6):108378.

Piccolis M*, Bond L*, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai Z, Gabriel KR, Elliot SD, Paulo JA, Harper JW, Weissman JS, Walther TC**, Farese RV Jr** (2019) Probing the global cellular responses to lipotoxicity caused by saturated fatty acids. Molecular Cell. 74:32–44.

Chitraju C, Walther TC**, Farese RV Jr** (2019) The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes. J Lipid Res. 60:1112-1120.

Gluchowski NL, Gabriel KR, Chitraju C, Bronson RT, Mejhert N, Boland S, Wang K, Lai ZW, Farese RV Jr**, Walther TC.** (2019) Hepatocyte deletion of triglyceride-synthesis enzyme acyl CoA:diacylglycerol acyltransferase 2 reduces steatosis without increasing inflammation or fibrosis in mice. Hepatology. Dec;70(6):1972-1985.

Chung J, Wu X, Lambert TJ, Lai ZW, Walther TC**, Farese RV Jr. ** (2019) LDAF1 and seipin form a lipid droplet assembly complex. Dev Cell. Dec 2;51(5):551-563. e7.

Prévost C*, Sharp ME*, Kory N, Lin Q, Voth GA**, Farese RV Jr**, Walther TC**. Mechanisms and determinants of amphipathic helix-containing protein targeting to lipid droplets. (2018) Dev Cell. 44(1):73-86.

Li Z, Lai ZW, Christiano R, Gazos-Lopes F, Walther TC**, Farese RV Jr.** (2018) Global analyses of selective insulin resistance in hepatocytes due to palmitate lipotoxicity. Mol Cell Proteomics. 17(5):836-849.

Nguyen AD, Nguyen TA, Zhang J, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC**, Farese RV Jr** (2018) Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A. 115(12):E2849-E2858.

Nguyen AD*, Nguyen TA*, Singh RK*, Eberle D*, Zhang J, Nguyen AD, Abate J, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV Jr. (2018) Progranulin in the hematopoietic compartment protects mice from atherosclerosis. Atherosclerosis. 277:145–154.

Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV Jr**, Walther TC.** (2018) Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells. Mol Biol Cell. 29:2045–2054.

Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV Jr**, Walther TC.** (2018) Cyro-electron microscopy structure oof the lipid droplet-formation protein seipin. J Cell Bio. 217:4080–4091.

Gluchowski NL, Chitraju C, Picoraro JA, Mehjert N, Pinto S, Xin W, Kamin D, Winter HS, Chung WK, Walther TC**, Farese RV Jr**. (2017) Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. J. Lipid Res. 58:1230–1237.

Chitraju C, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC**, Farese RV Jr**. (2017) Triglyceride synthesis by DGAT1 protects adipocytes from lipid-induced ER stress during lipolysis. Cell Metab. 26:407–418.

Gluchowski NL, Becuwe M, Walther TC**, Farese RV Jr** (2017) Lipid droplets and liver disease: from basic biology to clinical implications. Nat. Reviews Gastro. and Hepatol. 14:343–355.

Walther TC, Chung J, Farese RV Jr (2017) Lipid droplet biogenesis. Ann. Reviews Cell and Dev. Biol. 33:491–510.

Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC**, Farese RV Jr** (2016) Seipin organizes neutral lipids in the ER for initial lipid droplet formation. Elife. 5. pii: e16582.

Fröhlich F, Olson DK, Christiano R, Farese RV Jr, Walther TC. (2016) Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion. Proteomics. 16:2759–2763.

Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV Jr**, Walther TC**. (2016) Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism. J. Lipid Res. 58:226–235.

Kory N, Farese RV Jr**, Walther TC** (2016) Targeting fat: Mechanisms of protein localization to lipid droplets. Trends Cell Biol. 26:535–546.

Kory N*, Thiam AR*, Farese RV Jr**, Walther TC** Protein crowding is a determinant of lipid droplet protein composition. (2015) Dev. Cell. 10:34(3): 351–363.

Fröhlich  F, Petit C, Kory N, Christiano R, Hannibal-Bach H-K, Graham M, Liu X, Ejsing CS, Farese RV Jr **, Walther TC** (2015) The GARP complex is required for cellular sphingolipid homeostasis. Elife. e08712 doi: 10.7554/eLife.08712

Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV Jr (2014) High confidence proteomic analysis of yeast lipid droplets identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. J. Lipid Res. 55:1465–1477.

Wilfling F*, Haas JT*, Walther TC**, Farese RV Jr** (2014) Lipid droplet biogenesis. Curr. Opin. Cell Biol. 29:39–45.

Currie E, Schulze A, Zechner R, Walther TC, Farese RV Jr (2013) Cellular fatty acid metabolism and cancer. Cell Metab. 18:153–161.

Thiam AR, Farese RV Jr, Walther TC (2013) The biophysics and cell biology of lipid droplets. Nat. Rev. Mol. Cell Biol. 14:775–786.

Walther TC, Farese RV Jr (2012) Lipid droplets and cellular lipid metabolism. Annu. Rev. Biochem. 81:687–714.

Walther T, Farese RV Jr (2009) The life of lipid droplets. Biochim. Biophys. Acta. 1791:459–466.

Guo Y, Cordes KR, Farese RV Jr, Walther TC (2009) Lipid droplets at a glance. J. Cell Sci.  122 (pt. 6):749–752.

Krahmer N, Guo Y, Farese RV Jr, Walther TC (2009) Snap Shot: lipid droplets. Cell. 139:1024–1024e1.

Farese RV Jr, Walther TC (2009) Cell Essay: Lipid droplets finally get a little R-E-S-P-E-C-T. Cell. 139:855–860.

Chung J, Park J, Lai Z.W, Lambert T.J, Richards R.C, Farese RV Jr**, Walther TC**. (2021) The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets. (2021) bioRxiv, 2021.2008.2018.456894, doi:10.1101/2021.08.18.

Wang K, Lee C-W, Sui X, Kim S, Wang S, Higgs AB, Baublis AJ, Voth GA, Liao M, Walther TC**, Farese RV Jr**. (2022) The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7. bioRxiv 2022.09.15.508141; doi: https://doi.org/10.1101/2022.09.15.508141.

Bond LM, Ibrahim A, Lai ZW, Walzem RL, Bronson RT, Ilkayeva OR, Walther TC**, Farese RV Jr**. Fitm2 is required for ER homeostasis and normal function of murine liver. (2022) bioRxiv 2022.05.24.493342; doi: https://doi.org/10.1101/2022.05.24.493342.