Over the past ten years, we have investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in diverse types of cancer and can either restrain or promote cancer progression and metastasis. The Geissmann lab is now building on previous work to investigate mechanisms by which tissue macrophages may control tissue growth and metabolism and whether these same mechanisms play a role in cancer initiation and development.
Frederic Geissmann, MD, PhD
William E. Snee Chair of Immunology
Professor
Research Focus
My research is focused on cellular and molecular mechanisms that control the differentiation, maintenance, and physiological functions of macrophages and monocytes and their roles in tissue homeostasis and disease processes.Education
- MD, University of Paris, Paris VI Pierre et Marie Curie
- PhD, University of Paris, Paris V Rene-Descartes
- Office Phone: 646-888-3332
Lab Members
Anne Trumble-Koncelik
Lab Manager
Nehemiah Cox
Research Fellow
Zihou Deng
Research Fellow
Christian Jacome Galarza
Research Fellow
Stephanie Guillet
Graduate Research Assistant
Tomi Lazarov
Research Assistant
Pierre-Louis Loyher
Research Fellow
Carina Meyer
Graduate Research Assistant
Karen Reede
Administrative Secretary
Rocio Vicario
Research Fellow
Hairu Yang
Research Fellow
Publications
- Mass E, Jacome-Galarza CE, Blank T, Lazarov T, Durham BH, Ozkaya N, Pastore A, Schwabenland M, Chung YR, Rosenblum MK, Prinz M, Abdel-Wahab O, Geissmann F. (2017). A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease. Nature. Sept;549(7672):389-393.
- Cottineau J, Kottemann MC, Lach FP, Kang YH, Vély F, Deenick EK, Lazarov T, Gineau L, Wang Y, Farina A, Chansel M, Lorenzo L, Piperoglou C, Ma CS, Nitschke P, Belkadi A, Itan Y, Boisson B, Jabot-Hanin F, Picard C, Bustamante J, Eidenschenk C, Boucherit S, Aladjidi N, Lacombe D, Barat P, Qasim W, Hurst JA, Pollard AJ, Uhlig HH, Fieschi C, Michon J, Bermudez VP, Abel L, de Villartay JP, Geissmann F, Tangye SG, Hurwitz J, Vivier E, Casanova JL, Smogorzewska A, Jouanguy E. (2017). Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. Journal of Clinical Investigation May;127(5):1991-2006. PMC5409070
Selected Achievements
- Wellcome Trust Senior Investigator Award (2013)
- European Research Council Investigator Award (2010)
- MRC Strategic award (2009)
- European Young Investigator Award (EURYI award) (2006)
- Fellow of the Schlumberger Foundation for Education and research (2004)
