Immunology Program

The Frederic Geissmann Lab

Research

Frederic Geissmann, MD, PhD

William E. Snee Chair

Over the past ten years, we have investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in diverse types of cancer and can either restrain or promote cancer progression and metastasis. The Geissmann lab is now building on previous work to investigate mechanisms by which tissue macrophages may control tissue growth and metabolism and whether these same mechanisms play a role in cancer initiation and development.

Featured News

Memorial Sloan Kettering immunologist Frederic Geissmann

Feel the Burn: Researchers Identify Fat Storage Protein That Could Be Key to Alleviating Obesity

Researchers discover how immune cells called macrophages regulate whether fat is stored or burned.

In the Lab

Electronic microscope enlargement of macrophage cell (tinted green)

Origin Story: Finding on Macrophage Development Challenges Long-Held View

A surprising finding challenges long-held dogma about how certain immune cells develop into specialized types in diverse tissues.

Finding

Is Neurodegenerative Disease a Kind of Cancer?

New findings from experiments done in mice suggest a surprising cause of common neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

Publications Highlights

Mass E, Jacome-Galarza CE, Blank T, Lazarov T, Durham BH, Ozkaya N, Pastore A, Schwabenland M, Chung YR, Rosenblum MK, Prinz M, Abdel-Wahab O, Geissmann F. (2017). A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease. Nature. Sept;549(7672):389-393.

Cottineau J, Kottemann MC, Lach FP, Kang YH, Vély F, Deenick EK, Lazarov T, Gineau L, Wang Y, Farina A, Chansel M, Lorenzo L, Piperoglou C, Ma CS, Nitschke P, Belkadi A, Itan Y, Boisson B, Jabot-Hanin F, Picard C, Bustamante J, Eidenschenk C, Boucherit S, Aladjidi N, Lacombe D, Barat P, Qasim W, Hurst JA, Pollard AJ, Uhlig HH, Fieschi C, Michon J, Bermudez VP, Abel L, de Villartay JP, Geissmann F, Tangye SG, Hurwitz J, Vivier E, Casanova JL, Smogorzewska A, Jouanguy E. (2017). Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. Journal of Clinical Investigation May;127(5):1991-2006. PMC5409070

Menezes S, Melandri D, Anselmi G, Perchet T, Loschko J, Dubrot J, Patel R, Gautier EL, Hugues S, Longhi MP, Henry JY, Quezada SA, Lauvau G, Lennon-Duménil AM, Gutiérrez-Martínez E, Bessis A, Gomez-Perdiguero E, Jacome-Galarza CE, Garner H, Geissmann F, Golub R, Nussenzweig MC, Guermonprez P. (2016). The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+Macrophages or Monocyte-Derived Dendritic Cells. Immunity Dec;45(6):1205-1218. PMC5196026

Luis TC, Luc S, Mizukami T, Boukarabila H, Thongjuea S, Woll PS, Azzoni E, Giustacchini A, Lutteropp M, Bouriez-Jones T, Vaidya H, Mead AJ, Atkinson D, Böiers C, Carrelha J, Macaulay IC, Patient R, Geissmann F, Nerlov C, Sandberg R, de Bruijn MF, Blackburn CC, Godin I, Jacobsen SE. (2016). Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors. Nature Immunology Dec;17(12):1424-1435. PMC5172420

Mass E, Ballesteros I, Farlik M, Halbritter F, Günther P, Crozet L, Jacome-Galarza CE, Händler K, Klughammer J, Kobayashi Y, Gomez-Perdiguero E, Schultze JL, Beyer M, Bock C, Geissmann F. (2016). Specification of tissue-resident macrophages during organogenesis. Science Sep;353(6304). PMC5066309

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People

Frederic Geissmann, MD, PhD

William E. Snee Chair

My research is focused on cellular and molecular mechanisms that control the differentiation, maintenance, and physiological functions of macrophages and monocytes and their roles in tissue homeostasis and disease processes.
MD, University of Paris, Paris VI Pierre et Marie Curie
PhD, University of Paris, Paris V Rene-Descartes

[email protected]: Email Address
646-888-3332: Office Phone

Members

Araitz Alberdi Gonzalez — Araitz Alberdi-Gonzalez
Laboratory Manager

Lab Alumni

Leslie Weber, PhD — Leslie Weber
Research Associate

Daniel Authenrieth

Mathieu Bohm
Graduate Research Assistant

Xi Chen

Simao Coelho

Christian Jacome Galarza
Research Fellow

Hannah Garner

Stephanie Guillet
Graduate Research Assistant

Carina Meyer
Graduate Research Assistant

Katie Woodcock

Yi Zhao

Lab Affiliations

Immunology Program

Achievements

Wellcome Trust Senior Investigator Award (2013)
European Research Council Investigator Award (2010)
MRC Strategic award (2009)
European Young Investigator Award (EURYI award) (2006)
Fellow of the Schlumberger Foundation for Education and research (2004)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Postdoctoral Position

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Research Technicians, Research Assistants, or Research fellows

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Get in Touch

[email protected]

Lab Head Email
646-888-3332

Office Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Frederic Geissmann discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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