Immunology Program

The Gretchen Diehl Lab

Research

Gretchen Diehl, PhD
Gretchen Diehl, PhD
Catherine and Frederick R. Adler Chair for Junior Faculty

The intestinal immune system faces a number of unique challenges due to continuous exposure to rapidly changing exogenous factors including diet and intestinal microbes. Proper calibration of responses is needed to clear invading pathogens as well as repair damage. Over enthusiastic responses within the intestine impair barrier repair, amplifying damage and potentially lead to systemic infection or chronic inflammatory disease including inflammatory bowel disease (IBD). We find that the intestinal microbiota and dietary factors can promote or inhibit proper immune regulation. As such, we seek to define molecular and cellular pathways regulated by the microbiota, dietary, and tissue factors that are required to maintain homeostasis within the intestine. In defining upstream signals, we are working to understand microbial pathways and how they modulate tissue immunity. In parallel, we seek to delineate how these networks are disrupted in inflammatory conditions.

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Publications Highlights

Hill AA, Kim M, Zegarra-Ruiz DF, Chang LC, Norwood K, Assié A, Wu WH, Renfroe MC, Song HW, Major AM, Samuel BS, Hyser JM, Longman RS, Diehl GE*. Acute high-fat diet impairs macrophage-supported intestinal damage resolution. JCI Insight. 2023 Feb 8 ;8(3):e164489.

Zegarra Ruiz DF, Kim DV, Norwood K, Saldana-Morales FB, Kim M, Ng C, Callaghan R, Uddin M, Chang LC, Longman RS, Diehl GE*. Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer. Gut Microbes. 2022 Jan-Dec ;14(1):2119054.

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People

Gretchen Diehl, PhD

Gretchen Diehl, PhD

Catherine and Frederick R. Adler Chair for Junior Faculty

  • The Diehl lab studies how the microbiota and other exogenous factors regulate development and function of the intestinal immune system.
  • PhD, University of California, Berkeley
[email protected]
Email Address

Members

Gretchen Diehl, PhD
Gretchen Diehl

Catherine and Frederick R. Adler Chair for Junior Faculty

Mihir Pendse
Mihir Pendse

Research Scholar

Dasom Kim
Dasom Kim

Graduate Student

Ming-Ting Tsai
Ming-Ting Tsai

Graduate Student

Ryann Callaghan
Ryann Callaghan

Graduate Student

Monica Acosta
Monica Acosta

Graduate Student

Amanda Chen
Amanda Chen

Graduate Student

Dean Matthews
Dean Matthews

Graduate Student

Miozzottys Perez Rosario
Miozzottys Perez Rosario

MSK Bridge Program Scholar

Nikketa Stanford
Nikketa Stanford

Research Technician

Lab Alumni
Lin-Chun Chang
Lin-Chun Chang

Senior Research Scientist

Daniel Zegarra Ruiz
Daniel Zegarra Ruiz

Postdoctoral Associate

Fatima Saldana Morales
Fatima Saldana Morales

Graduate Student

Wan-Jung Wu
Wan-Jung Wu

Research Fellow

Lab Affiliations

Open Positions

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Gretchen Diehl discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


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This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

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