Gretchen Diehl: Publications


Hill A.A., Kim M., Zegarra-Ruiz D.F., Chang L.C., Norwood K., Assié A., Wu W.H., Renfroe M.C., Song H.W., Major A.M., Samuel B.S., Hyser J.M., Longman R.S., Diehl G.E.*. Acute high-fat diet impairs macrophage-supported intestinal damage resolution. JCI Insight. 2023 Feb 8 ;8(3):e164489.

Zegarra Ruiz D.F., Kim D.V., Norwood K., Saldana-Morales F.B., Kim M., Ng C., Callaghan R., Uddin M., Chang L.C., Longman R.S., Diehl G.E.*. Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer. Gut Microbes. 2022 Jan-Dec; 14(1):2119054.

Wu W.H., Kim M., Chang L.C., Assie A., Saldana-Morales F.B., Zegarra-Ruiz D.F., Norwood K., Samuel B.S., Diehl G.E.*. Interleukin-1β secretion induced by mucosa-associated gut commensal bacteria promotes intestinal barrier repair. Gut Microbes. 2022 Jan-Dec ;14(1):2014772. doi: 10.1080/19490976.2021.2014772.

Zegarra-Ruiz D.F., Kim D.V., Norwood K., Kim M., Wu W.H., Saldana-Morales F.B., Hill A.A., Majumdar S., Orozco S., Bell R., Round J.L., Longman R.S., Egawa T., Bettini M.L., Diehl G.E.*. Thymic development of gut-microbiota-specific T cells. Nature. 2021 Jun;594(7863):413-417. doi: 10.1038/s41586-021-03531-1. Epub 2021 May 12.

Saldana-Morales F.B., Kim D.V., Tsai M.T., Diehl G.E.*. Healthy Intestinal Function Relies on Coordinated Enteric Nervous System, Immune System, and Epithelium Responses. Gut Microbes. 2021 Jan-Dec;13(1):1-14.

Viladomiu M., Metz M.L., Lima S.F., Jin W-B., Chou L., JRI Live Cell Bank, Guo C-J., Diehl G.E.*, Simpson K.W., Scherl E.J., Longman R.S., 2021. Adherent-invasive E. coli metabolism of propanediol in Crohn’s disease regulates phagocytes to drive intestinal inflammation. Cell Host & Microbe.

Wu, W-J.H., Zegarra-Ruiz, D.F., Diehl G.E.*, 2020. Intestinal microbes in autoimmune and inflammatory disease. Frontiers in Immunology.

Kim M., Hill A.A., Wu W-J., Diehl G.E.*, 2019. Intestinal microbes direct CX3CR1+ cells to balance intestinal immunity. Gut Microbes. 10: 540-546.

Yuan X., Chang C-Y., You R., Shan M., Gu B-H., Madison M., Diehl, G.E.*, Perusich S., Song L-Z., Cornwell L., Rossen R., Wetsel R.A., Rajapakshe K., Coarfa C., Eltzschig H.K., Corry D., Kheradmand K., 2019. Cigarette smoke-induced reduction of C1q promotes emphysema. JCI Insight. 5. pii:124317. 

Kim M., Gu B., Maddison M.C., Song H., Norwood K., Hill A.A., Wu W-J, Corry D., Kheradmand F., Diehl G.E.*, 2019. Cigarette Smoke Induces Intestinal Inflammation via a Th17 cell-Neutrophil Axis. Frontiers in Immunology.

Castellanos J.G., Woo V., Viladomiu M., Perez A.R., Putzel G., Lima S., Diehl G.E.*, Marderstein A., Gandara J., Perez A.R., Withers D.R., Targan S.R., Shih D.Q., Scherl E.J., Longman R.S., 2018.  Microbiota-induced TNF-like Ligand 1A drives group 3 innate lymphoid cell-mediated barrier protection and intestinal T cell activation during colitis. Immunity. 49:1077-1089.e5.

Kim M.*, Galan C.*, Hill A.A.*, Wu W-J., Felhner-Peach H., Song H., Schady D., Bettini M.L., Simpson K.W., Longman R.S., Littman D.R., Diehl G.E.*, 2018. Critical role for the microbiota in CX3CR1+ intestinal mononuclear phagocyte regulation of intestinal T cell responses. Immunity. 49:151-163.

You R., DeMayo F.J., Liu J., Cho S.N., Burt B.M., Creighton C.J., Casal R.F., Lazarus D.R., Lu W., Tung H.Y., Yuan X., Hill-McAlester A., Kim M., Perusich S., Cornwell L., Rosen D., Song L.Z., Paust S., Diehl G.*, Corry D., Kheradmand F., 2018. IL17A Regulates Tumor Latency and Metastasis in Lung Adeno and Squamous SQ.2b and AD.1 Cancer. Cancer Immunol Res. 6:645-657.

Hong M.J., Gu B.H., Madison M., Landers C., Tung H.Y., Kim M., Yuan X., You R., MacHado A.A., Gilbert B.E., Soroosh P., Elloso M., Song L., Chen M., Corry D.B., Diehl G.E. *, Kheradmand F., 2017.  Protective Role of gd T Cells in Cigarette Smoke and Influenza Infection. Mucosal Immunology. 

Viladomiu M., Kivolowitz C., Abdulhamid A., Dogan B., Victorio D., Castellanos J.G., Woo V., Teng F., Tran N.L., Sczesnak A., Chai C., Kim M., Diehl G.E.*, Ajami N.J., Petrosino J.F., Zhou X.K., Schwartzman S., Mandl L.A., Abramowitz M., Jacob V., Bosworth B., Steinlauf A., Scherl E.J., Wu H.J., Simpson K.W., Longman R.S., 2017. IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote TH17-dependent inflammation. Science Translational Medicine, 9: eaaf9655.

Longman R.S.*, Diehl G.E.*, Victorio D.A., Huh J.R., Galan C., Miraldi E.R., Swaminath A., Bonneau R., Scherl E.J., Littman D.R., 2014. “CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.” Journal of Experimental Medicine, 211: 1571-83.

Derebe M.G., Zlatkov C.M., Gattu S., Ruhn K.A., Vaishnava S., Diehl, G.E.*, MacMillan J.B., Williams N.S., Hooper L.V., 2014. “Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection.” eLife, 3:e03206.

Diehl G.E.*, Longman R.S., Zhang J-X., Breart B., Galan C., Cuesta A., Schwab S.R., Littman D.R., 2013. “Microbiota Restrict Trafficking of Bacteria to Mesenteric Lymph Nodes by CX3CR1hi Cells.” Nature, 494: 116-20.

Longman R.S., Yang Y., Diehl G.E.*, Kim S.V., Littman D.R., 2013. “Microbiota: Host Interactions in Mucosal Homeostasis and Systemic Autoimmunity.” Cold Spring Harbor Symposia on Quantitative Biology, 78: 193-201.

Kinnebrew M., Buffie C., Diehl G.E.*, Zenewicz L.A., Leiner I., Hohl T.M., Flavell R.A., Littman D.R., Pamer E.G., 2012. “Interleukin 23 production by intestinal CD103+CD11b+ dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.” Immunity, 36: 276-87. 

Osborn S.L., Diehl G.*, Han S.J., Xue L., Kurd N., Hsieh K., Cado D., Robey E.A., Winoto A., 2010. “Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis.” Proc Natl Acad Sci,107: 13034-9.

Valdez Y., Diehl G.E.*, Vallance B.A., Grassl G.A., Guttman J.A., Brown N.F., Rosenberger C.M., Littman, D.R. Gros, P. Finlay B.B., 2008. “Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection.” Cellular Microbiology,10: 1646-61.

Zhang, J-X, Diehl G.E.*, Littman D.R., 2008. “Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells.” PLOS One, 3: e2035.

Ivanov I.I., Diehl G.E.*, Littman D.R., 2006. Lymphoid tissue inducer cells in intestinal immunity. Current Topics in Microbiology and Immunology, 308: 59-82.

Yue H.H.*, Diehl G.E.*, Winoto A., 2005. “Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53and adenomatous polyposis coli mutant mice.” Cell Death and Differentiation, 12: 94-97.

Diehl G.E.*, Yue H.H.*, Hsieh K., Kuang A.A., Ho M., Morici L.A., Lenz L.L., Cado D., Riley L.W., Winoto A., 2004. “TRAIL-R as a negative regulator of innate immune cell responses.” Immunity, 21: 877-9.

Kuang A.A., Diehl G.E.*, Zhang J., Winoto A., 2000. “FADD is required for DR4- and DR5-mediated apoptosis: lack of TRAIL-induced apoptosis in FADD-deficient mouse embryonic fibroblasts.” Journal of Biological Chemistry, 275: 25065-8.