The Parada lab uses genetically engineered mouse models to recapitulate and study human disease. These mouse strains are used to understand the natural history of tumors of the nervous system, including glioblastoma multiforme (GBM), malignant peripheral nerve sheath tumors (MPNST), neurofibromas, and other diseases associated with neurofibromatosis (NF1). We seek to develop mouse cancer models based on concrete hypotheses and to rapidly transfer findings for validation in human cancer samples.
Luis F. Parada, PhD
Director, Brain Tumor Center; Albert C. Foster Chair; American Cancer Society Research Professor
Research FocusDevelopmental biologist Luis F. Parada uses genetically engineered mouse models to study neurofibromatosis, brain tumors, cancer stem cells, and tumor progression.
EducationPhD, Massachusetts Institute of Technology
- TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response. Ma Z, Zang T, Birnbaum SG, Wang Z, Johnson JE, Zhang CL, Parada LF. Nat Commun. 2017 Nov 21;8(1):1668. doi: 10.1038/s41467-017-01709-8.
- Brain Tumor Stem Cells Remain in Play. Parada LF, Dirks PB, Wechsler-Reya RJ. J Clin Oncol. 2017 Jul 20;35(21):2428-2431. doi: 10.1200/JCO.2017.73.9540. Epub 2017 Jun 22. No abstract available.
- Member, National Academy of Science (2011)
- Fellow of American Association for the Advancement of Science (2009)
- Member, National Academy of Medicine- Former Institute of Medicine (2007)
- The Academy of Medicine, Engineering and Sciences of Texas (TAMEST) (2007)
- Member, American Academy of Arts and Sciences (2007)