Maria Jasin: Publications

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Maria Jasin: Publications

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Select Research Articles Since 2012  

Olvera-León R, Zhang F, Offord V, Zhao Y, Tan HK, Gupta P, Pal T, Robles-Espinoza CD, Arriaga-González FG, Matsuyama LSAS, Delage E, Dicks E, Ezquina S, Rowlands CF, Turnbull C, Pharoah P, Perry JRB, Jasin M, Waters AJ, Adams DJ. High-resolution functional mapping of RAD51C by saturation genome editing. Cell. 2024 Sep 16:S0092-8674(24)00968-1. doi: 10.1016/j.cell.2024.08.039. PMID: 39299233.

Carver A, Yu TY, Yates LA, White T, Wang R, Lister K, Jasin M, Zhang X. (2024) Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin. bioRxiv. doi: 10.1101/2024.07.16.603765.

Georgieva D, Wang N, Taglialatela A, Jerabek S, Reczek CR, Lim PX, Sung J, Du Q, Horiguchi M, Jasin M, Ciccia A, Baer R, Egli D. (2024) BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks. Cell Rep. doi: 10.1016/j.celrep.2024.114006.

Lim PX, Zaman M, Feng W, Jasin M. (2024) BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair. Mol Cell. doi: 10.1016/j.molcel.2023.12.025.

Rawal Y, Jia L, Meir A, Zhou S, Kaur H, Ruben EA, Kwon Y, Bernstein KA, Jasin M, Taylor AB, Burma S, Hromas R, Mazin AV, Zhao W, Zhou D, Wasmuth EV, Greene EC, Sung P, Olsen SK. (2023)Structural insights into BCDX2 complex function in homologous recombination. Nature. doi: 10.1038/s41586-023-06219-w.

Prakash R, Rawal Y, Sullivan MR, Grundy MK, Bret H, Mihalevic MJ, Rein HL, Baird JM, Darrah K, Zhang F, Wang R, Traina TA, Radke MR, Kaufmann SH, Swisher EM, Guérois R, Modesti M, Sung P, Jasin M, Bernstein KA. (2022) Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.2202727119.

Lukaszewicz A, Lange J, Keeney S, Jasin M. (2021)  De novo deletions and duplications at recombination hotspots in mouse germlines. Cell. doi: 10.1016/j.cell.2021.10.025.

Prakash R, Sandoval T, Morati F, Zagelbaum J, Lim P, White T, Taylor B, Wang R, Desclos E, Sullivan M, Rein H, Bernstein K, Krawczyk P, Gautier J, Modesti M, Vanoli F, and Jasin M. (2021) Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex. Nat Commun. doi: 10.1038/s41467-021-24205-6.

Abreu CM, Prakash R, Romanienko PJ, Roig I, Keeney S, Jasin M. (2018) Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination. Nat Commun. doi: 10.1038/s41467-018-06384-x.

Egli D, Zuccaro MV, Kosicki M, Church GM, Bradley A, Jasin M. Inter-homologue repair in fertilized human eggs? (2018) Nature. doi: 10.1038/s41586-018-0379-5.  

Garcin EB, Gon S, Sullivan MR, Brunette GJ, Cian A, Concordet JP, Giovannangeli C, Dirks WG, Eberth S, Bernstein KA, Prakash R, Jasin M, Modesti M. (2019) Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells.PLoS Genet. doi: 10.1371/journal.pgen.1008355.

Feng, W., Jasin, M., (2017) BRCA2 suppresses replication stress induced mitotic and G1 abnormalities through homologous recombination. Nat Commun 8:525. doi: 10.1038/s41467-017-00634-0.

Chen, C.C., Kass, E.M., Yen, W.F., Ludwig, T., Moynahan, M.E., Chaudhuri, J., and Jasin, M. (2017) ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair Proc Natl Acad Sci U S A, 14:7665-7670.

Vanoli, F., Tomishima, M., Feng, W., Lamribet, K., Babin, L., Brunet, E., and Jasin, M. (2017). CRISPR-Cas9-guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells. Proc Natl Acad Sci U S A 114, 3696-3701.

Lange, J., Yamada, S., Tischfield, S.E., Pan, J., Kim, S., Zhu, X., Socci, N.D., Jasin, M., and Keeney, S. (2016). The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair. Cell 167, 695-708 e616.

Kass, E.M., Lim, P.X., Helgadottir, H.R., Moynahan, M.E., and Jasin, M. (2016). Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation. Nat Commun 7, 13241.

Cole, F., Baudat, F., Grey, C., Keeney, S., de Massy, B., and Jasin, M. (2014). Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics. Nature Genet 46, 1072-1080.

Schlacher, K., Wu, H., and Jasin, M. (2012). A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell 22, 106-116.

Cole, F., Kauppi, L., Lange, J., Roig, I., Wang, R., Keeney, S., and Jasin, M. (2012). Homeostatic control of recombination is implemented progressively in mouse meiosis. Nat Cell Biol 14, 424-430.

Select Review Articles 

Medhi D, Jasin M. (2021) Repair-seq: Seeking and Perturbing DNA Repair. CRISPR J. doi: 10.1089/crispr.2021.29140.dme.

Brunet E, Jasin M. (2018). Induction of Chromosomal Translocations with CRISPR-Cas9 and Other Nucleases: Understanding the Repair Mechanisms That Give Rise to Translocations. Adv Exp Med Biol. doi: 10.1007/978-981-13-0593-1_2.

Lukaszewicz A, Lange J, Keeney S, Jasin M. Cell Cycle. (2018).Control of meiotic double-strand-break formation by ATM: local and global views. doi: 10.1080/15384101.2018.1464847. 

Feng, W., Jasin, M. (2018) Homologous recombination and replication fork protection: BRCA2 and more! Cold Spring Harb Symp Quant Biol. pii: 035006. doi: 10.1101/sqb.2017.82.035006.

Jasin, M., (2018). Under the Influence: Cas9 Ends and DNA Repair Outcomes. The CRISPR Journal, Vol. 1, No. 2

Chen CC, Feng W, Lim PX, Kass EM, Jasin M. (2018) Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer. Annu. Rev. Cancer Biol., 2, 313–36.