Cell Biology Program

The Marilyn Resh Lab

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Research

Marilyn Resh
Marilyn Resh, PhD
Member

The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family tyrosine protein kinases, Hedgehog and Wnt proteins.

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Research Projects

The Marilyn Resh Lab

Publications

Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat Chem Biol. 2013 Apr;9(4):247-9. doi: 10.1038/nchembio.1184. Epub 2013 Feb 17.

Resh MD. Targeting protein lipidation in disease. Trends Mol Med. 2012 Apr;18(4):206-14. doi: 10.1016/j.molmed.2012.01.007. Epub 2012 Feb 17.

Buglino JA, Resh MD. Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J Biol Chem. 2008 Aug 8;283(32):22076-88. doi: 10.1074/jbc.M803901200. Epub 2008 Jun 4.

Resh MD. Palmitoylation of ligands, receptors, and intracellular signaling molecules. Sci STKE. 2006 Oct 31;2006(359):re14.

Resh MD. Trafficking and signaling by fatty-acylated and prenylated proteins. Nat Chem Biol. 2006 Nov;2(11):584-90.

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People

Marilyn Resh

Marilyn Resh, PhD

Member

  • Cell biologist Marilyn Resh investigates the regulation of protein function by fatty acylation, and the development of Hedgehog palmitoylation inhibitors to block pancreatic and lung cancer.
  • PhD, Harvard University
  • AB, Princeton University
[email protected]
Email Address
212-639-2514
Office Phone

Members

Debra Alston
Debra Alston

Sr. Administrative Assistant

James Asciolla
James Asciolla

Graduate Student

Atul Khire, Ph.D.
Atul Khire, Ph.D.

Postdoctoral Fellow

Kalpana Rajanala, PhD
Kalpana Rajanala

Research Fellow

Adina Schonbrun
Adina R. Schonbrun
Jing Zhou, Ph.D.
Jing Zhou, Ph.D.

Postdoctoral Fellow

Raisa Louft-Nisenbaum
Raisa Louft-Nisenbaum

Research Technician

Marilyn Resh
Marilyn Resh

Member

Lab Alumni
Rita Curti
Rita Curti

Student Research Assistant

Brittany Haugen
Brittany Haugen

Graduate Student

Armine Matevossian
Armine Matevossian

Principal Scientist at EMD Sero Inc., Cambridge, MA

Lab Affiliations

Achievements

  • Excellence in Teaching and Mentoring Award, Weill Cornell Graduate School (2009)
  • Established Scientist, American Heart Association (1994-1999)
  • Pew Scholar in the Biomedical Sciences, Pew Charitable Trusts (1987-1991)
  • Discovery of the ""two-signal hypothesis"" for binding of myristoylated proteins to membranes
  • Discovery of a myristoyl switch mechanism for membrane binding of HIV-1 Gag
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  • First to establish Hedgehog acyltransferase as a bona fide palmitoyl acyltransferase for Hedgehog proteins
  • Discovery of the first-in-class hedgehog palmitoylation inhibitor

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