The Marilyn Resh Lab

The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family tyrosine protein kinases, Hedgehog and Wnt proteins.

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Marilyn Resh

Marilyn Resh, PhD



Research Focus

Cell biologist Marilyn Resh investigates the regulation of protein function by fatty acylation, and the development of Hedgehog palmitoylation inhibitors to block pancreatic and lung cancer.


  • PhD, Harvard University
  • AB, Princeton University

Lab Members

Selected Achievements
  • Excellence in Teaching and Mentoring Award, Weill Cornell Graduate School (2009)
  • Established Scientist, American Heart Association (1994-1999)
  • Pew Scholar in the Biomedical Sciences, Pew Charitable Trusts (1987-1991)
  • Discovery of the ""two-signal hypothesis"" for binding of myristoylated proteins to membranes
  • Discovery of a myristoyl switch mechanism for membrane binding of HIV-1 Gag
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  • First to establish Hedgehog acyltransferase as a bona fide palmitoyl acyltransferase for Hedgehog proteins
  • Discovery of the first-in-class hedgehog palmitoylation inhibitor