Cell Biology Program
The Marilyn Resh Lab
Research

The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family tyrosine protein kinases, Hedgehog and Wnt proteins.
Research Projects

Publications
People

Marilyn Resh, PhD
Member
- Cell biologist Marilyn Resh investigates the regulation of protein function by fatty acylation, and the development of Hedgehog palmitoylation inhibitors to block pancreatic and lung cancer.
- PhD, Harvard University
- AB, Princeton University
- [email protected]
- Email Address
- 212-639-2514
- Office Phone
Members



- 212-717-3317
- Office Fax
- 212-639-2551 or 2552
- Lab Phone


Sr. Administrative Assistant

Graduate Student

Postdoctoral Fellow

Research Fellow


Postdoctoral Fellow

Research Technician

Member


- BS, Florida Institute of Technology

- University of Massachusetts Amherst
- 212-639-2551
- Office Phone
Lab Alumni

Student Research Assistant

Graduate Student

Principal Scientist at EMD Sero Inc., Cambridge, MA
Lab Affiliations
Achievements
- Excellence in Teaching and Mentoring Award, Weill Cornell Graduate School (2009)
- Established Scientist, American Heart Association (1994-1999)
- Pew Scholar in the Biomedical Sciences, Pew Charitable Trusts (1987-1991)
- Discovery of the ""two-signal hypothesis"" for binding of myristoylated proteins to membranes
- Discovery of a myristoyl switch mechanism for membrane binding of HIV-1 Gag
Read more
- First to establish Hedgehog acyltransferase as a bona fide palmitoyl acyltransferase for Hedgehog proteins
- Discovery of the first-in-class hedgehog palmitoylation inhibitor
Get in Touch
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Lab Head Email
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Office Phone
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Office Fax
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Lab Phone
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Lab Fax
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Marilyn Resh discloses the following relationships and financial interests:
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Tri-Institutional Therapeutics Discovery Institute
Intellectual Property Rights
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].