Bingbing Wan

Research Associate

Bingbing Wan


2010 - Fudan University, China, PhD


Wan B, Wu J, Meng X, Lei M, Zhao X. Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Molecular Cell. 2019 Jul.

Wan B, Hang LE, Zhao X. Multi-BRCT scaffolds use distinct strategies to support genome maintenance. Cell Cycle. 2016 Oct;15(19):2561-2570. doi: 10.1080/15384101.2016.1218102. Epub 2016 Aug 11. Review. PubMed [PMID: 27580271]; PubMed Central PMCID: PMC5053572.

Bonner JN, Choi K, Xue X, Torres NP, Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown GW, Branzei D, Zhao X. Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates. Cell Rep. 2016 Jul 12;16(2):368-378. doi: 10.1016/j.celrep.2016.06.015. Epub 2016 Jun 30. PubMed [PMID: 27373152]; PubMed Central PMCID: PMC5051638.

Chen, Y., Wan, B., Wang, K.C., Cao, F., Yang, Y., Protacio, A., Dou, Y., Chang, H.Y., and Lei, M. (2011). Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding. EMBO Reports 12, 797-803.

Huang, J., Gurung, B., Wan, B., Matkar, S., Veniaminova, N.A., Wan, K., Merchant, J.L., Hua, X., and Lei, M. (2012). The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 482, 542-546.

Huang, J., Wan, B., Wu, L., Yang, Y., Dou, Y., and Lei, M. (2012). Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex. Cell Research 22, 1078-1081.

Sarkar, J., Wan, B., Yin, J., Vallabhaneni, H., Horvath, K., Kulikowicz, T., Bohr, V.A., Zhang, Y., Lei, M., and Liu, Y. (2015). SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates. Nucleic Acids Research 43, 5912-5923.

Wan, B., Tang, T., Upton, H., Shuai, J., Zhou, Y., Li, S., Chen, J., Brunzelle, J.S., Zeng, Z., Collins, K., et al. (2015). The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex. Nature Structural & Molecular Biology 22, 1023-1026.

Wan, B., Yin, J., Horvath, K., Sarkar, J., Chen, Y., Wu, J., Wan, K., Lu, J., Gu, P., Yu, E.Y., et al. (2013). SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Reports 4, 861-869.