Xiaolan Zhao: Publications

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Selected Research Papers

Yu Y, Li S, Ser Z, Sanyal T, Choi K, Wan B, Kuang H, Sali A, Kentsis A, Patel DJ, Zhao X. (2021) Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A. 118(19):e2026844118.

Dhingra N, Kuppa S, Wei L, Pokhrel N, Baburyan S, Meng X, Antony E, Zhao X (2021). The Srs2 helicase dampens DNA damage checkpoint by recycling RPA from chromatin . Proc Natl Acad Sci U S A. Feb 23;118(8):e2020185118.

Li S, Bonner JN, Wan B, So S, Summers A, Gonzalez L, Xue X, Zhao X (2021). Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes Dev . 35(3-4):261-272.

Shen M, Dhingra N, Wang Q, Cheng C, Zhu S, Tian , Yu J, Gong X, Li X, Zhang H, Xu X, Zhai L, Xie M, Gao Y, Deng H, He Y, Niu H, Zhao X, Xiang S (2021). Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nature Commun. 12: 321.

Meng X, Wei L, Devbhandari S, Zhang T, Xiang J, Remus D, Zhao X (2020). DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis. Nat Commun. 11(1):2437.

Wan B, Wu J, Meng X, Lei M, Zhao X.(2019) Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Molecular Cell 75, 238-251 .

Peng XP, Lim S, Li, S, Marjavaara L, Chabes A, Zhao X (2018) Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites PLoS Genet 14: e1007129

Bonner, J.N., Choi ,K., Xue, X., Torres, N.T., Szakal, B., Wei, L., Wan, B., Arter, M., Matos, J., Sung, P., Brown, P.W., Branzei, D. and Zhao, X. (2016) Smc5/6 mediated sumoylation of the Sgs1-Top3-Rmi1 complex promotes removal of recombination intermediates. Cell Reports 16, 368-378.

Wei, L., and Zhao, X. (2016). A new MCM modification cycle regulates DNA replication initiation. Nature Structural & Molecular Biology 23, 209–216.

Hang, L.E., Peng, J., Tan, W., Szakal, B., Menolfi, D., Sheng, Z., Lobachev, K., Branzei, D., Feng, W., and Zhao, X. (2015). Rtt107 Is a multi-functional scaffold supporting replication progression with partner SUMO and ubiquitin ligases. Molecular Cell 60, 268-279.

Xue, X., Choi, K., Bonner, J.N., Szakal, B., Chen, Y.H., Papusha, A., Saro, D., Niu, H., Ira, G., Branzei, D., Sung P., Zhao, X. (2015). Selective modulation of the functions of a conserved DNA motor by a histone fold complex. Genes & Development 29, 1000-1005.

Chung, I., and Zhao, X. (2015). DNA break-induced sumoylation is enabled by collaboration between a SUMO ligase and the ssDNA-binding complex RPA. Genes & Development 29, 1593-1598.

Xue, X., Choi, K., Bonner, J., Chiba, T., Kwon, Y., Xu, Y., Sanchez, H., Wyman, C., Niu, H., Zhao, X., Sung, P. (2014). Restriction of replication fork regression activities by a conserved SMC complex. Molecular Cell 56, 436-445.

Selected Reviews

Dhingra N, Zhao X. (2019). Intricate SUMO-based control of the homologous recombination machinery. Genes & Development 33, 1346-1354.

Zhao X (2018). SUMO-Mediated Regulation of Nuclear Functions and Signaling Processes. Mol Cell. 71(3):409-418.

Sarangi, P., and Zhao, X. (2015). SUMO-mediated regulation of DNA damage repair and responses. Trends in Biochemical Sciences 40, 233-242.

Xue, X., Sung, P., and Zhao, X. (2015). Functions and regulation of the multitasking FANCM family of DNA motor proteins. Genes & Development 29, 1777-1788.