Shibai Li, PhD

Senior Research Scientist
Shibai Li, PhD


Peking University, PhD


Chang JT, Li S, Beckwitt E, Than T, Haluska C, Chandanani J, O’Donnell ME, Zhao X*, Liu S* (*co-corresponding authors) (2022) Smc5/6’s multi-faceted DNA binding capacities stabilize branched DNA structuresNat Commun 13:7179

Li S, Mutchler S, Zhu X, So, S, Epps J, Guan D, Zhao X*, Xue X* (*co-corresponding authors) (2022). Multi-faceted regulation in the sumoylation of the Sgs1 DNA helicaseJBC 298:102092

Yu Y, Li S, Ser Z, Kuang H, Than T, Guan D, Zhao X*, Patel DJ. (*co-corresponding author)(2022). Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes. Proc Natl Acad Sci U S A. 2022 Jun 7;119(23):e2202799119. Epub 2022 Jun 1. PubMed PMID: 35648833.

Li S, Mutchler A, Zhu X, So S, Epps J, Guan D, Zhao X*, Xue X. (*co-corresponding author)(2022). Multi-faceted regulation of the sumoylation of the Sgs1 DNA helicase. J Biol Chem. 2022 May 30;:102092. [Epub ahead of print] PubMed PMID: 35654140.

Yan J, Li S, Kim YJ, Zeng Q, Radziejwoski A, Wang L, Nomura Y, Nakagami H, Somers DE (2021). TOC1 clock protein phosphorylation controls complex formation with NF-YB/C to repress hypocotyl growth. EMBO J. 40(24):e108684.

Yu Y, Li S, Ser Z, Sanyal T, Choi K, Wan B, Kuang H, Sali A, Kentsis A, Patel DJ, Zhao X. (2021) Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A. 118(19):e2026844118

Jo A, Li S, Shin JW, Zhao X, Cho Y. Structure Basis for Shaping the Nse4 Protein by the Nse1 and Nse3 Dimer within the Smc5/6 Complex (2021). J Mol Biol. Apr 30;433(9):166910. Epub 2021 Mar 4. PMID: 33676928.

Li S, Bonner JN, Wan B, So S, Summers A, Gonzalez L, Xue X, Zhao X (2021). Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes Dev. 35(3-4):261-272.

Peng XP, Lim S, Li, S, Marjavaara L, Chabes A, Zhao X (2018) Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites PLoS Genet. 14(1):e1007129.

Wu R, Li S, He S, Waßmann F, Yu C, Qin G, Schreiber L, Qu LJ, Gu H (2011). CFL1, a WW domain protein, regulates cuticle development by modulating the function of HDG1, a class IV homeodomain transcription factor, in rice and Arabidopsis. The Plant Cell 23 (9), 3392-3411.

Li R, Li J, Li S, G Qin, Novák O, Pěnčík A, Ljung K, Aoyama T, Liu J,… (2014) ADP1 affects plant architecture by regulating local auxin biosynthesis. PLoS genetics 10 (1), e1003954.

Li S, Wang X, He S, Li J, Huang Q, Imaizumi T, Qu L, Qin G, Qu LJ, Gu H (2016) CFLAP1 and CFLAP2 are two bHLH transcription factors participating in synergistic regulation of AtCFL1-mediated cuticle development in Arabidopsis. PLoS genetics 12 (1), e1005744.