Lei Wei

Former Graduate Student
Lei Wei


Tsinghua University

Current Position

Principal Investigator, School of Life Sciences, West Lake University, Zhejiang, China
Principal Investigator, Center for Infectious Disease Research, West Lake University, Zhejiang, China


Meng X, Wei L, Devbhandari S, Zhang T, Xiang J, Remus D, Zhao X. DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis. Nat Commun. 2020 May 15;11(1):2437. doi: 10.1038/s41467-020-16095-x. PubMed PMID: 32415104.

Whalen JM, Dhingra N, Wei L, Zhao X, Freudenreich CH. Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association. Cell Rep. 2020 May 12;31(6):107635. doi: 10.1016/j.celrep.2020.107635. PubMed PMID: 32402281.

Meng X, Wei L, Peng XP, Zhao X. Sumoylation of the DNA polymerase ε by the Smc5/6 complex contributes to DNA replication. PLoS Genet. 2019 Nov;15(11):e1008426. doi: 10.1371/journal.pgen.1008426. eCollection 2019 Nov. PubMed PMID: 31765372.

Dhingra N, Wei L, Zhao X. Replication protein A (RPA) sumoylation positively influences the DNA damage checkpoint response in yeast. J Biol Chem. 2019 Feb 22;294(8):2690-2699. doi: 10.1074/jbc.RA118.006006. Epub 2018 Dec 27. PubMed PMID: 30591583; PubMed Central PMCID: PMC6393611.

Wei L, Zhao X. Roles of SUMO in Replication Initiation, Progression, and Termination. Adv Exp Med Biol. 2017;1042:371-393. doi: 10.1007/978-981-10-6955-0_17. Review. PubMed PMID: 29357067; PubMed Central PMCID: PMC6643980.

Wei L, Zhao X. (2016). A new MCM modification cycle regulates DNA replication initiation. Nature Structural & Molecular Biology, 23, 209–216.

Bonner JN1 Choi K, Xue X, Torres NP, Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown GW, Branzei D, Zhao X. (2016) Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination IntermediatesCell Rep., 16, 368-78. PMCID: PMC5051638.

Hang LE, Lopez CR, Liu X, Williams JM, Chung I, Wei L, Bertuch AA, Zhao X. (2014). Regulation of Ku-DNA association by Yku70 C-terminal tail and SUMO modification. The Journal of Biological Chemistry, 289, 10308-10317.