Ming Li: Publications

Ming Li: Publications


Primary Papers

X. Zhang, S. Li, I. Malik, M.H. Do, L. Ji, C. Chou, W. Shi, K.J. Capistrano, J. Zhang, T. Hsu, B.G. Nixon, K. Xu, X. Wang, A. Ballabio, L.S. Schmidt, W.M. Linehan, M.O. Li. Reprogramming Tumor-Associated Macrophages to Outcompete Cancer Cells Nature 2023 619: 616-623. https://pubmed.ncbi.nlm.nih.gov/37380769/

B.G. Nixon, F. Kuo, L. Ji, M. Liu, K. Capistrano, M. Do, R.A. Franklin, X. Wu, E.R. Kansler, R.M. Srivastava, T.A. Purohit, A. Sanchez, L. Vuong, C. Krishna, X. Wang, H.C. Morse III, J.J. Hsieh, T.A. Chan, K.M. Murphy, J.J. Moon, A.A. Hakimi, M.O. Li. Tumor-Associated Macrophages Expressing the Transcription Factor IRF8 Promote T Cell Exhaustion in Cancer. Immunity 2022, 55: 2044-2058. https://pubmed.ncbi.nlm.nih.gov/36288724/

E.R. Kansler, S. Dadi, C. Krishna, B.G. Nixon, E.G. Stamatiades, M. Liu, F. Kuo, J. Zhang, X. Zhang, K. Capistrano, K.A. Blum, K. Weiss, R.M. Kedl, G. Cui, K. Ikuta, T.A. Chan, C.S. Leslie, A.A. Hakimi, M.O. Li. Cytotoxic Innate Lymphoid Cells Sense Cancer Cell-Expressed Interleukin-15 to Suppress Human and Murine Malignancies. Nat Immunol. 2022, doi: 10.1038/s41590-022-01213-2

C. Chou, X. Zhang, C. Krishna, B.G. Nixon, S. Dadi, K.J. Capistrano, E.R. Kansler, M. Steele, J. Han, A. Shyu, J. Zhang, E.G. Stamatiades, M. Liu, S. Li, M.H. Do, D.S. Kang, C. Chen, I.H. Wei, E.P. Pappou, M.R. Weiser, J. Garcia-Aguilar, J.J. Smith, C.S. Leslie, M.O. Li. Programme of Self-Reactive Innate-Like T Cell-Mediated Cancer Immunity. Nature 2022, 605: 139-145.

B.G. Nixon, C. Chou, C. Krishna, S. Dadi. A.O. Michel, A.E. Cornish, E.R. Kansler, M.H. Do, X. Wang, K.J. Capistrano. A.Y. Rudensky, C.S. Leslie, M.O. Li. Cytotoxic Granzyme C-Expressing ILC1s Contribute to Antitumor Immunity and Neonatal Autoimmunity. Sci Immunol. 2022, 7: eabi8642.

K. Xu, N. Yin, M. Peng, E.G. Stamatiades, S. Chhangawala, A. Shyu, P. Li, X. Zhang, M.H. Do, K.J. Capistrano, C. Chou, C.S. Leslie, M.O. Li. Glycolytic ATP Fuels Phosphoinositide 3-Kinase Signaling in Support of T Helper 17 Cell Responses. Immunity 2021, 54: 976-987.

K. Xu, N. Yin, M. Peng, E.G. Stamatiades, A. Shyu, P. Li, X. Zhang, M.H. Do, Z. Wang, K.J. Capistrano, C. Chou, A.G. Levine, A.Y. Rudensky, M.O. Li. Glycolysis Fuels Phosphoinositide 3-Kinase Signaling to Bolster T Cell Immunity. Science 2021, 371: 405-410.

S. Li, M. Liu, M.H. Do, C. Chou, E.G. Stamatiades, B.G. Nixon, W. Shi, X. Zhang, P. Li, S. Gao, K.J. Capistrano, H. Xu, N.V. Cheung, M.O. Li. Cancer Immunotherapy via Targeted TGF-beta Signaling Blockade in TH Cells. Nature 2020, 587: 121-125.

M. Liu, F. Kuo, K.J. Capistrano, D. Kang, B.G. Nixon, W. Shi, C. Chou, M.H. Do, E.G. Stamatiades, S. Gao, S. Li, Y. Chen, J.J. Hsieh, A.A. Hakimi, I. Taniuchi, T.A. Chan, M.O. Li. TGF-beta Suppresses Type 2 Immunity to Cancer. Nature 2020, 587: 115-120.

M.H. Do, X. Wang, X. Zhang, C. Chou, B.G. Nixon, K.J. Capistrano, M. Peng, A. Efeyan, D.M. Sabatani, M.O. Li. Nutrient mTORC1 Signaling Underpins Regulatory T Cell Control of Immune Tolerance. J. Exp. Med. 2020, 217: e20190848.

M. Peng, N. Yin, M.O. Li. SZT2 Dictates GATOR Control of mTORC1 Signaling. Nature 2017, 543: 433-437.

S.A. Oh, M. Liu, B.G. Nixon, D. Kang, A. Toure, M. Bivona, M.O. Li. Foxp3-Independent Mechanism by Which TGF-beta Controls Peripheral T Cell Tolerance. Proc Natl Acad Sci U S A 2017, 114: E7536-E7544.

C.T. Luo, H.U. Osmanbeyoglu, M.H. Do, M.R. Bivona, A. Toure, D. Kang, Y. Xie, C.S. Leslie, M.O. Li. Ets Transcription Factor GABP Controls T Cell Homeostasis and Immunity. Nat Commun. 2017, 8: 1062.

M. Peng, N. Yin, S. Chhangawala, K. Xu, C.S. Leslie, M.O. Li. Aerobic Glycolysis Promotes T Helper 1 Cell Differentiation Through an Epigenetic Mechanism. Science 2016, 354: 481-484.

S. Dadi, S. Chhangawala, B.M. Whitlock, R.A. Franklin, C.T. Luo, S.A. Oh, A. Toure, Y. Pritykin, M. Huse, C.S. Leslie, M.O. Li. Cancer Immunosurveillance by Tissue-resident Innate Lymphoid Cells and Innate-like T Cells. Cell 2016, 164: 365-377.

C.T. Luo, W. Liao, S. Dadi, A. Toure, M.O. Li. Graded Foxo1 Activity in Regulatory T Cells Differentiates Tumor Immunity from Spontaneous Autoimmunity. Nature 2016, 529: 532-536.

M. Peng, N. Yin, M.O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell 2014, 159: 122-133.

R.A. Franklin, W. Liao, A. Sarkar, M.V. Kim, M.R. Bivona, K. Liu, E.G. Pamer, M.O. Li. The Cellular and Molecular Origin of Tumor-associated Macrophages. Science 2014, 344: 921-925.

W. Ouyang, S.A. Oh, Q. Ma, M.R. Bivona, J. Zhu, M.O. Li. TGF-beta Cytokine Signaling Promotes CD8+ T Cell Development and Low-affinity CD4+ T Cell Homeostasis by Regulation of IL-7Ralpha Expression. Immunity 2013, 39: 335-346.

M.V. Kim, W. Ouyang, W. Liao, M.Q. Zhang, M.O. Li. The Transcription Factor Foxo1 Controls Central Memory CD8+ T Cell Responses to Infection. Immunity 2013, 39: 286-297.

W. Ouyang, W. Liao, C.T. Luo, N. Yin, M. Huse, M.V. Kim, M. Peng, P. Chan, Q. Ma, Y. Mo, D. Meijer, K. Zhao, A.Y. Rudensky, G. Atwal, M.Q. Zhang, M.O. Li. Novel Foxo1-dependent Transcriptional Programs Control Treg Cell Function. Nature 2012, 491: 554-559.

M.K. Donkor, A. Sarkar, P.A. Savage, R.A. Franklin, L.K. Johnson, A.A. Jungbluth, J.P. Allison, M.O. Li. T Cell Surveillance of Oncogene-induced Prostate Cancer is Impeded by T Cell-derived TGF-beta1 Cytokine. Immunity 2011, 35: 123-134.

I. Gutcher, M. Donkor, Q. Ma, A.Y. Rudensky, R.A. Flavell, M.O. Li. Autocrine Transforming Growth Factor-beta1 Promotes in vivo Th17 Cell Differentiation. Immunity 2011, 34: 396-408.

W. Ouyang, O. Beckett, Q. Ma, J. Paik, R.A. DePinho, M.O. Li. Foxo Proteins Cooperatively Control the Differentiation of Foxp3+ Regulatory T Cells. Nat Immunol. 2010, 11: 618-627.

W. Ouyang, O. Beckett, Q. Ma, M.O. Li. TGF-beta Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development. Immunity 2010, 32: 642-653.

W. Ouyang, O. Beckett, R.A. Flavell, M.O. Li. An Essential Role of the Forkhead-Box Transcription Factor Foxo1 in Control of T Cell Homeostasis and Tolerance. Immunity 2009, 30: 358-371.

Review Articles

B.G. Nixon, S. Gao, X. Wang, M.O. Li. TGF-beta Control of Immune Responses in Cancer: A Holistic Immuno-Oncology Perspective Nat Rev Immunol. 2023, 23: 346-362. https://pubmed.ncbi.nlm.nih.gov/36380023/

X. Zhang, L. Ji, M.O. Li. Control of Tumor-Associated Macrophage Responses by Nutrient Acquisition and Metabolism. Immunity 2023, 56: 14-31. https://pubmed.ncbi.nlm.nih.gov/36630912/

S. Gao, T.W. Hsu, M.O. Li. Immunity Beyond Cancer Cells: Perspective from Tumor Tissue. Trends Cancer 2021, 7: 1010-1019.

M.O. Li, N. Wolf, D.H. Raulet, L. Akkari, M.J. Pittet, P.C. Rodriguez, R.N. Kaplan, A. Munitz, Z. Zhang, S. Cheng, N. Bhardwai. Innate Immune Cells in the Tumor Microenvironment. Cancer Cell 2021, 39: 725-729.

C. Chou, M.O. Li. Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages. Front Immunol. 2018, 9: 2104.

M. Liu, S. Li, M.O. Li. TGF-beta Control of Adaptive Immune Tolerance: A Break from Treg Cells. Bioessays 2018, 40: e1800063.

S. Sanjabi, S.A. Oh, M.O. Li. Regulation of the Immune Response by TGF-beta: From Conception to Autoimmunity and Infection. Cold Spring Harb Perspect Biol. 2017, 9: pii: a022236.

M.O. Li, A.Y. Rudensky. T Cell Receptor Signaling in the Control of Regulatory T Cell Differentiation and Function. Nat Rev Immunol. 2016, 16: 220-233.

R.A. Franklin, M.O. Li. Ontogeny of Tumor-associated Macrophages and Its Implication in Cancer Regulation. Trends Cancer 2016, 2: 20-34.

S. Oh, M.O. Li. TGF-beta: Guardian of T Cell Function. J. Immunol. 2013, 191: 3973-3979.

C. Luo, M.O. Li. Transcriptional Control of Regulatory T Cell Development and Function. Trends Immunol. 2013, 34: 531-539.

W. Ouyang, M.O. Li. Foxo: in Command of T-lymphocyte Homeostasis and Tolerance. Trends in Immunol. 2011, 32: 26-33. PMC:3053075