Robert Benezra: Publications

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Benezra, R., Davis, R.L., Lockshon, D., Turner, D.L. & Weintraub, H. (1990). The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61(1):49-59.

Jen, Y., Weintraub, H. & Benezra, R. (1992). Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins. Genes Dev 6(8):1466-79.

Pesce, S. & Benezra, R. (1993). The loop region of the helix-loop-helix protein Id1 is critical for its dominant negative activity. Mol Cell Biol 13(12):7874-80.

Tournay, O. & Benezra, R. (1996). Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1. Mol Cell Biol 16(5):2418-30.

Li ,Y. & Benezra, R. (1996). Identification of a human mitotic checkpoint gene: hsMAD2. Science 274(5285):246-8.

Jen, Y., Manova, K. & Benezra, R. (1996). Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis. Dev Dyn 207(3):235-52.

Wassmann, K. & Benezra, R. (1998). Mad2 transiently associates with an APC/p55Cdc complex during mitosis. Proc Natl Acad Sci USA 95(19):11193-8.

Lyden, D., Young, A.Z., Zagzag, D., Yan, W., Gerald, W., O’Reilly, R., Bader, B.L., Hynes, R.O., Zhuang, Y., Manova, K. & Benezra, R. (1999). Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 401(6754):670-7.

Dobles, M., Liberal, V., Scott, M.L., Benezra, R. & Sorger, P.K. (2000). Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 101(6):635-45.

Lyden, D., Hattori, K., Dias, S., Costa, C., Blaikie, P., Butros, L., Chadburn, A., Heissig, B., Marks, W., Witte, L., Wu, Y., Hicklin, D., Zhu, Z., Hackett, N.R., Crystal, R.G., Moore, M.A., Hajjar, K.A., Manova, K., Benezra, R.* & Rafii, S.* (2001). Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 7(11):1194-201. *Co-corresponding authors.

Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S.W. & Benezra, R. (2007). Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 11(1):9-23.

 Gupta, G.P., Perk, J., Acharyya, S., de Candia, P., Mittal, V., Todorova-Manova, K., Gerald, W.L., Brogi, E., Benezra, R.* & Massague, J.* (2007). ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc        Natl Acad Sci USA 104(49):19506-11. *Co-corresponding authors

Ciarrocchi, A., Jankovic, V., Shaked, Y., Nolan, D.J., Mittal, V., Kerbel, R., Nimer, S. & Benezra, R. (2007). Id1 restrains p21 expression to control endothelial progenitor cell formation. PLoS One 2(12):e1338.

Henke, E., Perk, J., Vider, J., de Candia, P., Chin, Y., Solit, D.B., Ponomarev, L., Cartegni, K., Manova, N., Rosen, N. & Benezra, R. (2008). Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo. Nat Biotechnol 26(1):91-100.

Nam, H.S. & Benezra, R. (2009). High levels of Id1 expression define B1 type adult neural stem cells. Cell Stem Cell 5(5):515-26.

Schvartzman, J.M.*, Sotillo, R.* & Benezra, R. (2010). Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer 10(2):102-15. *Both authors contributed equally

Sotillo, R., Schvartzman, J.M., Socci, N.D., & Benezra, R. (2010). Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 464(7287):436-40.

Schvartzman, J.M., Duijf, P.H., Sotillo, R., Coker, C., & Benezra, R. (2011). Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. Cancer Cell 19(6):701-14.

Granot, Z., Henke, E., Comen, E., King, T., Norton, L., & Benezra, R. (2011). Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 20(3):300-14.

Duijf, P.H., Schultz, N., & Benezra, R. (2013). Cancer cells preferentially lose small chromosomes. Int J Cancer 132(10):2316-26.

Stankic, M., Pavlovic, S., Chin, Y., Brogi, E., Padua, D., Norton, L., Massague, J., & Benezra, R. (2013). TGF-β-Id1 signaling opposes Twist1 andI promotes metastatic colonization via a mesenchymal-to-epithelial transition. Cell Rep 5(5):1228-42.

Lasorella, A., Benezra, R., & Iavarone, A. (2014). The ID proteins: master regulators of cancer stem cells and tumour aggressiveness. Nat Rev Cancer 14(2):77-91

Zhang, N., Yantiss, R., Nam, H.S., Chin, Y., Zhou, X., Scherl, E., Bosworth, B., Subbaramaiah, K., Dannenberg, A.*, & Benezra, R.* (2014). ID1 is a functional marker for intestinal stem and progenitor cells required for normal response to injury. Stem Cell Reports 3(5):716-24. *Co-corresponding authors

Cook, P.J., Thomas, R., Kinglsey, P.J., Fumiko, S., Montrose, D.C., Marnett, L.J., Tabar, V.S., Dannenberg, A.J.*, & Benezra, R.* (2016). Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma. Neuro-Oncology 18(10):1379-89. PMC5035519. *Co-corresponding authors.

Marks, D.H.*, Thomas, R.*, Shah, R., Khoo, C., Benezra, R. (2017). Mad2 overexpression uncovers a critical role for TRIP13 in mitotic exit. Cell Reports, 19:1832-1845. *Co-first authors

Cook, P. J., Thomas, R., Kannan, R., Sanchez de Leon, E., Drillon, A., Rosenblum, M. K., Scaltriti, M., Benezra, R.*, and Ventura, A.* (2017). Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target. Nat Comm, 8:15987 . *Co-corresponding authors