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MSK developmental biologist Lorenz Studer
Q&A
Taking Aim at Parkinson’s Disease: A Conversation with Developmental Biologist Lorenz Studer

In an interview in September 2020, Dr. Studer spoke about what he hopes he and his fellow investigators can accomplish with this generous support.
Regulatory proteins (gold balls) bind to enhancer regions (light blue) and promoter regions (pink) of DNA to form clusters that enable transcription (purple).
Going the Distance: How DNA Enhancers Communicate with Their Target Genes

Scientists at the Sloan Kettering Institute are learning how far-flung regions of genes connect to start the process of making proteins.
An illustration of a beta-amyloid plaque among the neurons in a brain.
Article
MSK Study Links Inflammation to Alzheimer’s Disease Development

An enzyme that contributes to plaque formation in the brain also serves as a first line of defense against bacteria and viruses, suggesting a link between the two.
Black blobs on a white background
In the Lab
Separation Anxiety: Cell Division Gone Awry Leads to Genetic Chaos

Researchers shed light on how aberrant cell division can cause the kind of mutations often found in cancer cells.
Large International Study Pinpoints Impact of TP53 Gene Mutations on Blood Cancer Severity

Having two mutated copies of the TP53 gene — as opposed to a single mutated copy — is associated with worse outcomes in a blood cancer called myelodysplastic syndrome, according to a new study led by researchers at Memorial Sloan Kettering.
Section of a lung cancer tumor in mice
Finding
A Never-Before-Seen Cell State May Explain Cancer’s Ability to Resist Drugs

Identified in mice, this unusual cell state emerges early during tumor evolution and gives tumors enormous malleability.
Charles Sawyers in his lab
A New Approach in Prostate Cancer: Targeting the Cells Surrounding the Tumor

Scientists have found a protein that empowers prostate tumors to resist hormone therapy.
MSK physician-scientists Michael Glickman and Gil Redelman-Sidi
The ABCs of BCG: Oldest Approved Immunotherapy Gets New Explanation

BCG has been used to treat bladder cancer for more than 30 years. Scientists are still learning how it works.
An illustration of sugar being sprinkled on a cancer cell.
In the Lab
Just Add Sugar: How a Protein’s Small Change Leads to Big Trouble for Cells

A study from investigators in the Sloan Kettering Institute uncovers the details of how a key protein called GRP94 becomes disrupted, leading to cancer and other diseases.
Confocal microscopy image of a female fruit fly brain.
In the Lab
How Fruit Flies Know When They've Mated

Research from investigators at the Sloan Kettering Institute shows how a brain circuit controls mating behavior in fruit flies.