Structural Biology Program

The Stephen Long Lab

Research

Stephen B. Long, PhD
Stephen B. Long, PhD
Member

Our laboratory uses a combination of structural biology and biophysical techniques to discover how ion channels and membrane-embedded enzymes function at the atomic level. The proteins we study are crucial for the function of the immune system, vision, cell differentiation, and embryonic development, and they are potential targets for diseases including immune disorders and cancer. Our discoveries lead to new understandings of the fundamental mechanisms of the ion channels and enzymes. These understandings also guide our efforts to develop and evaluate small molecule and biologic modulators for therapeutic potential for cancer and other diseases.

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Publications Highlights

Delgado B.D. & Long S.B. (2022). Mechanisms of ion selectivity and throughput in the mitochondrial calcium uniporter. Science Advances 

Wang, C.*, Polovitskaya, M.M.*, Delgado, B.D., Jentsch, T. J., & Long, S.B. (2022). Gating choreography and mechanism of the human proton-activated chloride channel ASOR. Science Advances

Jiang, Y., Benz, T. L., & Long, S.B. (2021). Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT. Science

Hou, X.*, Outhwaite, I.R.*, Pedi, L., and Long, S.B. (2020). Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation. Elife 9. (Abstract | Open Conformation Cryo-EM map & Atomic Coordinates). *X. Hou and I.R. Outhwaite are co-first authors.

Wang, C., Jacewicz, A., Delgado, B.D., Baradaran, R., and Long, S.B. (2020). Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2. Elife 9. (Abstract | Holocomplex Cryo-EM map & Atomic Coordinates | MICU1-MICU2 complex Cryo-EM map & Atomic Coordinates)

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People

Stephen B. Long, PhD

Stephen B. Long, PhD

Member

  • The Long laboratory investigates the molecular mechanisms of ion channels and enzymatic membrane proteins and seeks to use these discoveries to benefit humanity.
  • BA, Physics, Amherst College, 1994
  • PhD, Biochemistry, Duke University, 2001
  • Postdoc, Rockefeller University, 2007
[email protected]
Email Address
212-639-2903
Office Phone

Members

Bryce Delgado
Bryce D. Delgado

Graduate Student

Nandish Khanra
Nandish Kumar Khanra

Senior Research Scientist

Swati Pant
Swati Pant

Graduate Student

David J. Van Dongen
David J. Van Dongen

Graduate Student

Stephanie Woods
Stephanie Woods

Assistant and Lab Coordinator

Qing Zhang
Qing Zhang

Research Scholar

Lab Alumni
Veronica Kane-Dickson

Postdoctoral Fellow

Pictured: David Kerr
David Kerr

Undergraduate Researcher

Rozbeh Baradaran
Rozbeh Baradaran

Postdoc

Thomas Benz

Research Technician

Shana Burstein

Research Technician

Melinda Diver

Graduate Student

Xiaowei Hou, PhD
Xiaowei Hou

Senior Research Scientist

Agata Jacewicz
Agata Jacewicz

Senior Research Scientist

Yiyang Jiang
Yiyang Jiang

Research Scholar

Pictured: Alexandria Miller
Alexandria N. Miller

Assistant Professor, University of Iowa - Molecular Physiology and Biophysics, Iowa City, IA

Ian Outhwaite
Ian Outhwaite

Research Technician

Leanne Pedi
Leanne Pedi

Senior Research Assistant

Nicole Trezza

Research Technician

George Vaisey, MBiochem
George Vaisey

Graduate Student

Chongyuan Wang
Chongyuan Wang

Postdoctoral Fellow & Senior Research Scientist

Lab Affiliations

Achievements

  • Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
  • Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
  • Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)
  • Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Stephen B. Long discloses the following relationships and financial interests:

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The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

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