Stephen B. Long: Publications

Stephen B. Long: Publications

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View a full listing of Stephen B. Long: Publications’ journal articles.

Pant, S., Tam, S. W., & Long, S. B. (2025). The pentameric chloride channel BEST1 is activated by extracellular GABA. Proceedings of the National Academy of Sciences, 122(16). Proceedings of the National Academy of Sciences

Khanra, N. K., Wang, C., Delgado, B. D., & Long, S. B. (2025). Structure of the human TWIK-2 potassium channel and its inhibition by pimozide. bioRxiv, 2025.02.24.639991. bioRxiv

Delgado B.D. & Long S.B. (2022). Mechanisms of ion selectivity and throughput in the mitochondrial calcium uniporter. Science Advances 

Wang, C.*, Polovitskaya, M.M.*, Delgado, B.D., Jentsch, T. J., & Long, S.B. (2022). Gating choreography and mechanism of the human proton-activated chloride channel ASOR. Science Advances

Jiang, Y., Benz, T. L., & Long, S.B. (2021). Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT. Science

Hou, X.*, Outhwaite, I.R.*, Pedi, L., and Long, S.B. (2020). Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation. Elife 9. (Abstract | Open Conformation Cryo-EM map & Atomic Coordinates). *X. Hou and I.R. Outhwaite are co-first authors.

Wang, C., Jacewicz, A., Delgado, B.D., Baradaran, R., and Long, S.B. (2020). Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2. Elife 9. (Abstract | Holocomplex Cryo-EM map & Atomic Coordinates | MICU1-MICU2 complex Cryo-EM map & Atomic Coordinates)

Wang, C.*, Baradaran, R.*, and Long, S.B. (2020). Structure and Reconstitution of an MCU-EMRE Mitochondrial Ca2+ Uniporter Complex. J Mol Biol 432, 5632-5648. (Abstract | MCU-EMRE Cryo-EM map & Atomic Coordinates). *C. Wang and R. Baradaran are co-first authors.

Miller, A. N.*, Vaisey, G.*, & Long, S. B. (2019). Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin. eLife (Abstract | open state Cryo-EM map & Atomic Coordinates).  *A. N. Miller and G. Vaisey are co-first authors.

Vaisey, G., & Long, S. B. (2018). An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1. The Journal of General Physiology, jgp.201812190. (Abstract)

Hou, X., Burstein, S. R., & Long, S. B. (2018). Structures reveal opening of the store-operated calcium channel Orai. eLife, 7.  (Manuscript | Atomic Coordinates)

Baradaran, R., Wang, C., Siliciano, A. F., & Long, S. B. (2018). Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters. Nature, 559(7715), 580–584. (Abstract | Atomic Coordinates & Cryo-EM map)

Melinda Diver, Leanne Pedi, Akiko Koide, Shohei Koide, Stephen B. Long (2018). Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT. Nature. Jan 25; 553(7689):526-529. (Abstract | Manuscript | Atomic Coordinates)

George Vaisey, Alexandria Miller, Stephen B. Long. Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel. PNAS.  Published online November 7 2016. (Abstract | Atomic Coordinates)

Veronica K. Dickson, Leanne Pedi, Stephen B. Long.  Structure and insights into the function of a Ca2+-activated Cl− channel.  Nature. 2014 Dec 11;516(7530):213-8.  Published online 22 October 2014. (Abstract | Atomic Coordinates)

Melinda M. Diver and Stephen B. Long.  Mutational Analysis of the Integral Membrane Methyltransferase ICMT Reveals Potential Substrate Binding Sites. J Biol Chem. 2014. Sep 19;289(38):26007-20.  Epub 2014 Jul 24 (Abstract)

Xiaowei Hou, Leanne Pedi, Melinda M. Diver, Stephen B. Long. Crystal structure of the calcium release-activated calcium channel Orai. Science. 2012 Dec 7;338(6112):1308-13. Epub 2012 Nov 22. (Abstract | PDF Reprint | Atomic Coordinates)

Alexandria N. Miller and Stephen B. Long.  Crystal structure of the human two-pore domain potassium channel K2P1. Science. 2012 Jan 27;335(6067):416-7. (Abstract | PDF Reprint | Atomic Coordinates)

Long SB, Tao X, Campbell EB, MacKinnon R. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature. 2007 Nov 15;450(7168):376-82. (Abstract | Atomic Coordinates)

Long SB, Campbell EB, Mackinnon R. Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science. 2005 Aug 5;309(5736):897-903. (Abstract | Atomic Coordinates)

Long SB, Campbell EB, Mackinnon R. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science. 2005 Aug 5;309(5736):903-8. (Abstract)

Long SB, Casey PJ, Beese LS. Reaction path of protein farnesyltransferase at atomic resolution. Nature. 2002 Oct 10;419(6907):645-50.  (Abstract | Atomic Coordinates: 1KZP  1KZO)