We investigate how leukocytes are rapidly targeted to sites of “danger” in intact tissues, i.e. how they detect wounds or sites of infection. Misregulation of this process may lead to hyper-inflammatory disease. Chronic inflammatory states, in turn, promote cancer. Although the complex cytokine networks that govern amplification and resolution of inflammatory responses have been intensely studied, the initial mechanisms that regulate leukocyte targeting in tissues remain very little understood.
Philipp Niethammer, PhD
Research FocusCell biologist Philipp Niethammer investigates wound responses using advanced imaging approaches in zebrafish.
- PhD, European Molecular Biology Laboratories
- B. Enyedi, S. Kala, T. Nikolich-Zugich, P. Niethammer. Tissue damage detection by osmotic surveillance. Nature cell biology. 15(9), 1123-30. 2013.
- P. Niethammer, C. Grabher, A.T. Look, T.J. Mitchison. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature, 459, 996-9. 2009.
- European Molecular Biology Organization Long Term Fellow (2006)
- Human Frontiers Science Program Long Term Fellow (2007)
- Dorsett L. Spurgeon Distinguished Research Award (2009)
- Louis Gerstner Young Investigator (2012)
- American Asthma Foundation Scholar (2014)