Our laboratory uses a combination of cryo-electron microscopy, x-ray crystallography, and functional approaches to study the mechanisms of eukaryotic ion channels involved in calcium sigaling and membrane-embedded enzymes.

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The Stephen Long Lab

Stephen B. Long, PhD

Associate Member


Research Focus

Structural biologist Stephen Long studies the mechanisms of ion channels and enzymatic membrane proteins.


  • BA, Physics, Amherst College, 1994
  • PhD, Biochemistry, Duke University, 2001
  • Postdoc, Rockefeller University, 2007


  • Veronica K. Dickson, Leanne Pedi, Stephen B. Long.  Structure and insights into the function of a Ca2+-activated Cl− channel.  Nature. doi:10.1038/nature13913.  Published online 22 October 2014. (Abstract | Atomic Coordinates)
  • Melinda M. Diver and Stephen B. Long.  Mutational Analysis of the Integral Membrane Methyltransferase ICMT Reveals Potential Substrate Binding Sites. J Biol Chem. 2014. Sep 19;289(38):26007-20.  Epub 2014 Jul 24 (Abstract)
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Selected Achievements

  • Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
  • Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)