Stephen Long Lab

Our laboratory uses a combination of cryo-electron microscopy, x-ray crystallography, and functional approaches to study the mechanisms of eukaryotic ion channels involved in calcium signaling and membrane-embedded enzymes.

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The Stephen Long Lab

Stephen B. Long, PhD



Research Focus

Structural biologist Stephen Long studies the mechanisms of ion channels and enzymatic membrane proteins.


  • BA, Physics, Amherst College, 1994
  • PhD, Biochemistry, Duke University, 2001
  • Postdoc, Rockefeller University, 2007


  • Melinda Diver, Leanne Pedi, Akiko Koide, Shohei Koide, Stephen B. Long. Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT. Nature. 2018 Jan 25; 553(7689):526-529. (Abstract | Manuscript | Atomic Coordinates)
  • George Vaisey, Alexandria Miller, Stephen B. Long. Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel. PNAS. doi: 10.1073/pnas.1614688113.  Published online November 7 2016. (Abstract | Atomic Coordinates)
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Selected Achievements

  • Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
  • Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)