Jubierre L, Rodriguez Fos, Planas-Felix, Lewis, Cameron, Demarest, Nabila, Zhao, Bergin, Reed, Yamada, Socci, Hayes, Rabadan, Torrents, Kruer, Toth, Kentsis A. A transposase-derived gene required for human brain development. bioRxiv.
Bigot Y, Yamada M, Mueller H, Morell V, Alves S, Lecomte T, Kentsis A. Analysis of DNA transposition by DNA transposases in human cells. bioRxiv.
Kazansky Y, Cameron D, Demarest P, Zaffaroni N, Arrighetti N, Zuco V, Kuwahara Y, Qu R, de Stanchina E, Dela Cruz F, Kung A, Gounder M, Kentsis A. Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy. bioRxiv.
Keller R, Yamada M, Cameron D, Suzuki H, Sanghrajka R, Vaynshteyn J, Gerwin J, Maura F, Hooper W, Shah M, Robine N, Demarest P, Bayin SN, Jubierre L, Reed C, Taylor MD, Joyner AL, Raju PG, Kentsis A. Childhood cancer mutagenesis caused by a domesticated DNA transposase. bioRxiv.
Takao S, Morell V, Brown FC, Koche R, Kentsis A. Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance. bioRxiv.
Kwok N, Aretz Z, Takao S, Ser Z, Cifani P, Kentsis A. Integrative proteogenomics using ProteomeGenerator2. J Proteome Research, 2023
Agulnik A et al, SAFER Ukraine Collaborative including Kentsis A. Global effort to evacuate Ukrainian children with cancer and blood disorders who have been affected by war. Lancet Haematology, 2022
Cifani P, Kentsis A. Quantitative Cell Proteomic Atlas: Pathway-scale targeted mass spectrometry for high-resolution functional profiling of cell signaling. J Proteome Research, 2022
Heikamp EB, Henrich JA, Perner F, Wong EM, Hatton C, Wen Y, Barwe SP, Gopalakrishnapillai A, Xu H, Uckelmann HJ, Takao S, Kazansky Y, Pikman Y, McGeehan GM, Kolb EA, Kentsis A, Armstrong SA. The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML. Blood, 2022
Cifani P, Kentsis A. Automated Multidimensional Nanoscale Chromatography for Ultrasensitive Targeted Mass Spectrometry. Methods Mol Biol, 2022
Cifani P, Li Z, Luo D, Grivainis M, Intlekofer AM, Fenyö D, Kentsis A. Discovery of Protein Modifications Using Differential Tandem Mass Spectrometry Proteomics. J Proteome Research, 2021
Takao S, Forbes L, Uni M, Cheng S, Pineda JMB, Tarumoto Y, Cifani P, Minuesa G, Chen C, Kharas MG, Bradley RK, Vakoc CR, Koche RP, Kentsis A. Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia. eLife, 2021
Kentsis A. Why do young people get cancer? Pediatr Blood Cancer, 2020
Kentsis A, Frank SA. Developmental Mutators and Early Onset Cancer. Front Pediatr, 2020
Ortiz MV, Ahmed S, Burns M, Henssen AG, Hollmann TJ, MacArthur I, Gunasekera S, Gaewsky L, Bradwin G, Ryan J, Letai A, He Y, Naranjo A, Chi YY, LaQuaglia M, Heaton T, Cifani P, Dome JS, Gadd S, Perlman E, Mullen E, Steen H, Kentsis A. Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms’ tumor. JCI Insight, 2019
Ser Z, Cifani P, Kentsis A. Optimized cross-linking mass spectrometry for in situ interaction proteomics. J Proteome Research, 2019
McNeer NA, Philip J, Geiger H, Ries RE, Lavallée VP, Walsh M, Shah M, Arora K, Emde AK, Robine N, Alonzo TA, Kolb EA, Gamis AS, Smith M, Gerhard DS, Guidry-Auvil J, Meshinchi S, Kentsis A. Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia. Leukemia, 2018
Cifani P, Dhabaria A, Chen Z, Yoshimi A, Kawaler E, Abdel-Wahab O, Poirier JT, Kentsis A. ProteomeGenerator: A framework for comprehensive proteomics based on de novo transcriptome assembly and high-accuracy peptide mass spectral matching. J Proteome Research, 2018
Brown FC, Still E, Koche RP, Yim CY, Takao S, Cifani P, Reed C, Gunasekera S, Ficarro SB, Romanienko P, Mark W, McCarthy C, de Stanchina E, Gonen M, Seshan V, Bhola P, O’Donnell C, Spitzer B, Stutzke C, Lavallée VP, Hébert J, Krivstov AV, Melnick A, Paietta EM, Tallman MS, Letai A, Sauvageau G, Pouliot G, Levine R, Marto JA, Armstrong SA, Kentsis A. MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia. Cancer Discovery, 2018
Ramaswamy K, Forbes L, Minuesa G, Gindin T, Brown F, Kharas MG, Krivtsov AV, Armstrong SA, Still E, de Stanchina E, Knoechel B, Koche R, Kentsis A. Peptidomimetic blockade of MYB in acute myeloid leukemia. Nature Communications, 2018
Gutierrez A & Kentsis A. Acute myeloid/T-lymphoblastic leukaemia (AMTL): a distinct category of acute leukaemias with common pathogenesis in need of improved therapy. Br J Haematol, 2018
Henssen A, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur I, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A. Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Science TM, 2017
Cifani P, Kentsis A. High sensitivity quantitative proteomics using automated multidimensional nano-flow chromatography and accumulated ion monitoring on quadrupole-Orbitrap-linear ion trap mass spectrometer. Mol Cell Proteomics, 2017
Henssen A, Koche R, Zhuang J, Jiang E, Reed C, Eisenberg A, Still E, Rodriguez-Fos E, Gonzalez S, Puiggros M, Blackford A, Mason C, De Stanchina E, Gonen M, Emde A, Shah M, Arora K, Reeves C, Socci N, Perlman E, Antonescu C, Roberts C, Steen H, Mullen E, Jackson S, Torrents D, Weng Z, Armstrong S, Kentsis A. PGBD5 promotes site-specific oncogenic mutations in human tumors. Nature Genetics, 2017
Cifani P, Shakiba M, Chhangawala S, Kentsis A. ProteoModlR for functional proteomics. BMC Bioinformatics, 2017
Brown FC, Cifani P, Drill E, He J, Still E, Zhong S, Balasubramanian S, Pavlick D, Yilmazel B, Knapp KM, Alonzo TA, Meshinchi S, Stone RM, Kornblau SM, Marcucci G, Gamis AS, Byrd JC, Gonen M, Levine RL, Kentsis A. Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia. Br J Haematol, 2017
Cifani P, Kentsis A. High Sensitivity Quantitative Proteomics Using Automated Multidimensional Nano-flow Chromatography and Accumulated Ion Monitoring on Quadrupole-Orbitrap-Linear Ion Trap Mass Spectrometer. Mol Cell Proteomics, 2017
Henssen AG, Jiang E, Zhuang J, Pinello L, Socci ND, Koche R, Gonen M, Villasante CM, Armstrong SA, Bauer DE, Weng Z, Kentsis A. Forward genetic screen of human transposase genomic rearrangements. BMC Genomics, 2016
Ortiz MV, Kobos R, Walsh M, Slotkin EK, Roberts S, Berger MF, Hameed M, Solit D, Ladanyi M, Shukla N, Kentsis A. Integrating Genomics Into Clinical Pediatric Oncology Using the Molecular Tumor Board at the Memorial Sloan Kettering Cancer Center. Pediatr Blood Cancer, 2016
Henssen AG, Henaff E, Jiang E, Eisenberg AR, Carson JR, Villasante CM, Ray M, Still E, Burns M, Gandara J, Feschotte C, Mason CE, Kentsis A. Genomic DNA transposition induced by human PGBD5. eLife, 2015
Dhabaria A, Cifani P, Reed C, Steen H, Kentsis A. A High-Efficiency Cellular Extraction System for Biological Proteomics. J Proteome Res, 2015
McGee SF, Kornblau SM, Qiu Y, Look AT, Zhang N, Yoo SY, Coombes KR, Kentsis A. Biological properties of ligand-dependent activation of the MET receptor kinase in acute myeloid leukemia. Leukemia, 2015
Mansour MR, Reed C, Eisenberg AR, Tseng JC, Twizere JC, Daakour S, Yoda A, Rodig SJ, Tal N, Shochat C, Berezovskaya A, DeAngelo DJ, Sallan SE, Weinstock DM, Izraeli S, Kung AL, Kentsis A, Look AT. Cite Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia. Br J Haematol, 2015
View a full listing of Alex Kentsis: Publications’ journal articles.