Our studies in cancer biology and pediatric oncology are focused on cellular plasticity, a phenomenon that relates both to the fundamental mechanisms of cancer pathogenesis and to the development of improved rational therapies. Detailed information about our research is available at http://alexkentsis.net.
Alex Kentsis, MD, PhD
Assistant Professor
Research Focus
Cancer biologist and pediatric oncologist Alex Kentsis leads research in the functional proteomics and molecular pharmacology of refractory childhood cancers.Education
- MD, Mount Sinai School of Medicine
- PhD, New York University
- Office Phone: 1-646-888-2593
- Assistant: Nandini Shivmangal 1-646-888-3860
- Lab Phone: 1-646-888-3557
Lab Members
Lauren Forbes
Graduate Student
Michael Ortiz
Instructor
Paolo Cifani
Research Fellow
Phillip Demarest
Research Technician
Shehana Gunasekera
Research Technician
Luz Jubierre Zapater
Research Fellow
Ross Keller
Research Fellow
Isaac Krasnopolsky
Research Technician
Nicole McNeer
Clinical Fellow
Caroline Robb
Research Fellow
Zheng Ser
Graduate Student
Nandini Shivmangal
Administrative Assistant
Sumiko Takao
Research Fellow
Christina Yim
Research Fellow
Publications
- Cifani P, Dhabaria A, Chen Z, Yoshimi A, Kawaler E, Abdel-Wahab O, Poirier JT, Kentsis A. ProteomeGenerator: A framework for comprehensive proteomics based on de novo transcriptome assembly and high-accuracy peptide mass spectral matching. J Proteome Research 2018
- Brown FC, Still E, Koche RP, Yim CY, Takao S, Cifani P, Reed C, Gunasekera S, Ficarro SB, Romanienko P, Mark W, McCarthy C, de Stanchina E, Gonen M, Seshan V, Bhola P, O’Donnell C, Spitzer B, Stutzke C, Lavallée VP, Hébert J, Krivstov AV, Melnick A, Paietta EM, Tallman MS, Letai A, Sauvageau G, Pouliot G, Levine R, Marto JA, Armstrong SA, Kentsis A. MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia. Cancer Discovery, 2018
Selected Achievements
- St. Baldrick’s Robert J. Arceci Innovation Award, Elected Member of American Society for Clinical Investigation, Society for Pediatric Research Young Investigator Award (2018), Rita Allen Foundation Scholar Award, Damon Runyon Cancer Research Foundation Clinical Investigator Award (2016), American Society of Hematology Scholar Award (2014), Burroughs Wellcome Fund Career Award for Medical Scientists (2013)
- Pediatric Hematology-Oncology Fellowship, Dana-Farber Cancer Institute, Residency in Pediatrics, Boston Children’s Hospital, Harvard Medical School
- MD, PhD, Mount Sinai School of Medicine and New York University
- AB, SM, University of Chicago
