Molecular Pharmacology Program
The Alex Kentsis Lab
Research

We study the biology of cancers that affect children and young adults ranging from embryonal tumors in infants, leukemias and brain tumors in children, and sarcomas in young adults. Scientists in our group use inter-disciplinary experimental tools as they work to understand the fundamental causes of cancer and to develop definitive therapies for their control. Detailed information about our research is available at http://alexkentsis.net.

Featured News
Publications
Kentsis A. Why do young people get cancer? Pediatr Blood Cancer, 2020
Ortiz MV, Ahmed S, Burns M, Henssen AG, Hollmann TJ, MacArthur I, Gunasekera S, Gaewsky L, Bradwin G, Ryan J, Letai A, He Y, Naranjo A, Chi YY, LaQuaglia M, Heaton T, Cifani P, Dome JS, Gadd S, Perlman E, Mullen E, Steen H, Kentsis A. Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms’ tumor. JCI Insight, 2019
Ser Z, Cifani P, Kentsis A. Optimized cross-linking mass spectrometry for in situ interaction proteomics. J Proteome Research, 2019
McNeer NA, Philip J, Geiger H, Ries RE, Lavallée VP, Walsh M, Shah M, Arora K, Emde AK, Robine N, Alonzo TA, Kolb EA, Gamis AS, Smith M, Gerhard DS, Guidry-Auvil J, Meshinchi S, Kentsis A. Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia. Leukemia, 2018
Cifani P, Dhabaria A, Chen Z, Yoshimi A, Kawaler E, Abdel-Wahab O, Poirier JT, Kentsis A. ProteomeGenerator: A framework for comprehensive proteomics based on de novo transcriptome assembly and high-accuracy peptide mass spectral matching. J Proteome Research, 2018
People

Alex Kentsis, MD, PhD
- Cancer biologist and pediatric oncologist Alex Kentsis leads research in the functional proteomics and molecular pharmacology of refractory childhood cancers.
- MD, Mount Sinai School of Medicine
- PhD, New York University
- kentsisresearchgroup@gmail.com
- Email Address
- 1-646-888-2593
- Office Phone
- View physician profile
- Physician profile
Members







Research Fellow
Research Technician
Research Fellow
Clinical Fellow

Research Fellow

Graduate Student

Research Fellow
Research Technician

Research Fellow
Graduate Student

Graduate Student

Research Fellow

Research Fellow
Lab Affilations
Achievements
- Louise and Allston Boyer Award for Clinical Research
- Terry Ann Krulwich Physician-Scientist Alumni Award (2020)
- Pershing Square Sohn Prize
- Leukemia & Lymphoma Society Scholar Award (2019)
- St. Baldrick’s Robert J. Arceci Innovation Award
Read more
- Elected Member of American Society for Clinical Investigation
- Society for Pediatric Research Young Investigator Award (2018)
- Rita Allen Foundation Scholar Award
- Damon Runyon Cancer Research Foundation Clinical Investigator Award (2016)
- American Society of Hematology Scholar Award (2014)
- Burroughs Wellcome Fund Career Award for Medical Scientists (2013)
- Pediatric Hematology-Oncology Fellowship, Dana-Farber Cancer Institute
- Residency in Pediatrics, Boston Children’s Hospital, Harvard Medical School
- MD, PhD, Mount Sinai School of Medicine and New York University
- AB, SM, University of Chicago
Lab News & Events
Upcoming event
Synthetic Lethality of Wnt Pathway Activation and Asparaginase for Cancer Therapy
This seminar will be conducted by Zoom Webinar.
Open Positions
Career Opportunities
Get in Touch
-
Lab Head Email
-
Office Phone
-
Lab Phone