Molecular Pharmacology Program

The Alex Kentsis Lab


Pictured: Alex Kentsis
Alex Kentsis, MD, PhD

We study the biology of cancers that affect children and young adults ranging from embryonal tumors in infants, leukemias and brain tumors in children, and sarcomas in young adults. Scientists in our group use inter-disciplinary experimental tools as they work to understand the fundamental causes of cancer and to develop definitive therapies for their control. Detailed information about our research is available at

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Kentsis Research Group


Cifani P, Li Z, Luo D, Grivainis M, Intlekofer AM, Fenyö D, Kentsis A. Discovery of Protein Modifications Using Differential Tandem Mass Spectrometry Proteomics. J Proteome Research, 2021

Takao S, Forbes L, Uni M, Cheng S, Pineda JMB, Tarumoto Y, Cifani P, Minuesa G, Chen C, Kharas MG, Bradley RK, Vakoc CR, Koche RP, Kentsis A. Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia. eLife, 2021

Kentsis A. Why do young people get cancer? Pediatr Blood Cancer, 2020

Kentsis A, Frank SA. Developmental Mutators and Early Onset Cancer. Front Pediatr, 2020

Ortiz MV, Ahmed S, Burns M, Henssen AG, Hollmann TJ, MacArthur I, Gunasekera S, Gaewsky L, Bradwin G, Ryan J, Letai A, He Y, Naranjo A, Chi YY, LaQuaglia M, Heaton T, Cifani P, Dome JS, Gadd S, Perlman E, Mullen E, Steen H, Kentsis A. Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms’ tumor. JCI Insight, 2019

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Pictured: Alex Kentsis

Alex Kentsis, MD, PhD

  • Cancer biologist and pediatric oncologist Alex Kentsis leads research in the functional proteomics and molecular pharmacology of refractory childhood cancers.
  • MD, Mount Sinai School of Medicine
  • PhD, New York University
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Physician profile


Daniel Cameron

Research Technician

Shuyuan Cheng

Graduate Student

Luz Jubierre Zapater, PhD
Luz Jubierre Zapater

Research Fellow

Yaniv Kazansky
Yaniv Kazansky

Graduate Student

Danmeng Luo
Danmeng Luo

Research Fellow

Victor Morell

Research Technician

Helen Mueller

Research Fellow

Jack Ralls

Graduate Student

Sumiko Takao

Senior Research Scientist

Masahiro Uni
Masahiro Uni

Research Fellow

Makiko Yamada

Senior Research Scientist

Lab Affiliations


  • Louise and Allston Boyer Award for Clinical Research
  • Terry Ann Krulwich Physician-Scientist Alumni Award (2020)
  • Pershing Square Sohn Prize
  • Leukemia & Lymphoma Society Scholar Award (2019)
  • Josie Robertson Investigator (2013-2018)
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  • St. Baldrick’s Robert J. Arceci Innovation Award
  • Elected Member of American Society for Clinical Investigation
  • Society for Pediatric Research Young Investigator Award (2018)
  • Rita Allen Foundation Scholar Award
  • Damon Runyon Cancer Research Foundation Clinical Investigator Award (2016)
  • American Society of Hematology Scholar Award (2014)
  • Burroughs Wellcome Fund Career Award for Medical Scientists (2013)
  • Pediatric Hematology-Oncology Fellowship, Dana-Farber Cancer Institute
  • Residency in Pediatrics, Boston Children’s Hospital, Harvard Medical School
  • MD, PhD, Mount Sinai School of Medicine and New York University
  • AB, SM, University of Chicago

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