Cancer Biology & Genetics Program
The Craig Thompson Lab
The Thompson laboratory has proposed that the basis of metazoan cell survival is determined by the inability of cells to take up nutrients in a cell-autonomous fashion. This hypothesis was formulated to explain how multicellularity might have arisen during evolution. We believe the lack of a cell-intrinsic mechanism to regulate nutrient uptake provides the first and most fundamental barrier to cell transformation.
King, B., Araki, J., Palm, W., & Thompson, C. B. (2020). Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis. Genes & development, 10.1101/gad.340661.120. Advance online publication.
Vardhana, S. A., Hwee, M. A., Berisa, M., Wells, D. K., Yost, K. E., King, B., Smith, M., Herrera, P. S., Chang, H. Y., Satpathy, A. T., van den Brink, M., Cross, J. R., & Thompson, C. B. (2020). Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen. Nature immunology, 21(9), 1022–1033.
Schwörer, S., Berisa, M., Violante, S., Qin, W., Zhu, J., Hendrickson, R. C., Cross, J. R., & Thompson, C. B. (2020). Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress. The EMBO journal, 39(8), e103334.
Li, A. M., Ducker, G. S., Li, Y., Seoane, J. A., Xiao, Y., Melemenidis, S., Zhou, Y., Liu, L., Vanharanta, S., Graves, E. E., Rankin, E. B., Curtis, C., Massagué, J., Rabinowitz, J. D., Thompson, C. B., & Ye, J. (2020). Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism. Molecular cancer research : MCR, 18(4), 599–611.
Craig B. Thompson, MD
President and CEO, Memorial Sloan Kettering Cancer Center
- Memorial Sloan Kettering President Craig Thompson studies molecular signaling pathways that regulate nutrient uptake and the role these pathways play in the regulation of cell growth and survival.
- MD, University of Pennsylvania
- Email Address
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Craig B. Thompson discloses the following relationships and financial interests:
Howard Hughes Institute
Provision of Services
University of Michigan
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