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The Daniel Heller Lab: Publications

View a full listing of Daniel A. Heller’s journal articles.


Selected Publications

TV Galassi, PV Jena, J Shah, G Ao, E Molitor, Y Bram, A Frankel, J Park, J Jessurun, DS Ory, A Haimovitz-Friedman, D Roxbury, J Mittal, M Zheng, R E Schwartz, DA Heller*. “An Optical Nanoreporter of Endolysosomal Lipid Accumulation Reveals Enduring Effects of Diet on Hepatic Macrophages In Vivo.” Science Translational Medicine 10 (2018) eaar2680. 

RM Williams, C Lee, TV Galassi, JD Harvey, R Leicher, M Sirenko, M Dorso, J Shah, N Olvera, F Dao, DA Levine,DA Heller*. “Non-Invasive Ovarian Cancer Biomarker Detection via an Optical Nanosensor Implant.” Science Advances 4 (2018) eaaq1090.

Y Shamay, J Shah, DF Tschaharganeh, D Roxbury, J Budhathoki-Uprety, M Işık, A Mizrachi, K Nawaly, JL Sugarman, E Baut, MR Neiman, DC Johnson, R Sridharan, KL Chu, VK Rajasekhar, JD Chodera, SW Lowe, DA Heller*, “Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines” Nature Materials 4 (2018) 361-368.

Jena PV, Roxbury D, Galassi TV, Akkari L, Horoszko CP, Iaea DB, Budhathoki-Uprety J, Pipalia N, Haka AS, Harvey JD, Mittal J, Maxfield FR, Joyce JA, Heller DA. A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux. ACS Nano 11 (2017) 10689-1070.

J Budhathoki-Uprety, RE Langenbacher, PV Jena, D Roxbury, DA Heller*: “A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway.” ACS Nano 11 (2017) 3875-3882.

JD Harvey, PV Jena, HA Baker, GH Zerze, RM Williams, TV Galassi, D Roxbury, J Mittal, DA Heller: “A Carbon Nanotube Reporter of miRNA Hybridization Events In Vivo.” Nature Biomedical Engineering 1 (2017) 0041.

A Mizrachi, Y Shamay, J Shah, S Brook, J Soong, V Rajasekhar, J Humm, J Healey, S Powell, J Baselga, DA Heller*, A Haimovitz-Friedman*, M Scaltriti*: “Tumor-specific PI3K inhibition via nanoparticle delivery in head and neck squamous cell carcinoma.” Nature Communications 8 (2017) 14292.

Y Shamay, M Elkabets, H Li, J Shah, S Brook, F Wang, K Adler, E Baut, M Scaltriti, PV Jena, EE Gardner, JT Poirier, CM Rudin, J Baselga, A Haimovitz-Friedman, DA Heller*: “P-selectin is a Nanotherapeutic Delivery Target to the Tumor Microenvironment.” Science Translational Medicine 8 (2016) 345ra8 [Highlighted in Science Translational Medicine 8 (2016) 374fs11, Nature Reviews Clinical Oncology (2016), and Cancer Discovery (2016).]


Full Publications List

(63) TV Galassi, PV Jena, J Shah, G Ao, E Molitor, Y Bram, A Frankel, J Park, J Jessurun, DS Ory, A Haimovitz-Friedman, D Roxbury, J Mittal, M Zheng, R E Schwartz, DA Heller*. “An Optical Nanoreporter of Endolysosomal Lipid Accumulation Reveals Enduring Effects of Diet on Hepatic Macrophages In Vivo.” Science Translational Medicine 10 (2018) eaar2680. 

(62) RM Williams, C Lee, DA Heller*. “A Fluorescent Carbon Nanotube Sensor Detects the Metastatic Prostate Cancer Biomarker uPA.” ACS Sensors 3 (2018) 1838–1845.

(61) JD Harvey, GH Zerze, KM Tully, J Mittal, DA Heller*. “Electrostatic Screening Modulates Analyte Binding and Emission of Carbon Nanotubes.” Journal of Physical Chemistry C (2018)

(60) RM Williams, C Lee, TV Galassi, JD Harvey, R Leicher, M Sirenko, M Dorso, J Shah, N Olvera, F Dao, DA Levine, DA Heller*. “Non-Invasive Ovarian Cancer Biomarker Detection via an Optical Nanosensor Implant.” Science Advances 4 (2018) eaaq1090.

(59) Y Shamay, J Shah, DF Tschaharganeh, D Roxbury, J Budhathoki-Uprety, M Işık, A Mizrachi, K Nawaly, JL Sugarman, E Baut, MR Neiman, DC Johnson, R Sridharan, KL Chu, VK Rajasekhar, JD Chodera, SW Lowe, DA Heller*, “Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines” Nature Materials (2018)

(58) RM Williams, J Shah, HS Tian, Xi Chen, F Geissman, EA Jaimes, DA Heller*, “Selective Nanoparticle Targeting of the Renal Tubules.” Hypertension 71 (2018) 87-94.

[Highlighted in Hypertension Perspective, Yap, et. al., 2017]

(57) JD Harvey, HA. Baker, E Mercer, J Budhathoki-Uprety, DA Heller*, “Control of carbon nanotube solvatochromic response to chemotherapeutic agents.” ACS Applied Materials & Interfaces 9 (2017) 37947-37953.

(56) Sims CM, Hanna SK, Heller DA, Horoszko CP, Johnson ME, Montoro Bustos AR, Reipa V, Riley KR, Nelson BC. Redox-active nanomaterials for nanomedicine applications. Nanoscale. 2017 Oct 19;9(40):15226-15251. doi: 10.1039/c7nr05429g. Review.

(55) Jena PV, Roxbury D, Galassi TV, Akkari L, Horoszko CP, Iaea DB, Budhathoki-Uprety J, Pipalia N, Haka AS, Harvey JD, Mittal J, Maxfield FR, Joyce JA, Heller DA. A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux. ACS Nano. 2017 Sep 12. doi: 10.1021/acsnano.7b04743. [Epub ahead of print]

(54) Harvey JD, Baker HA, Mercer E, Budhathoki-Uprety J, Heller DA. Control of Carbon Nanotube Solvatochromic Response to Chemotherapeutic Agents. ACS Appl Mater Interfaces. 2017 Nov 1;9(43):37947-37953. doi: 10.1021/acsami.7b12015. Epub 2017 Oct 19.

(53) Jena PV, Safaee MM, Heller DA, Roxbury D. DNA-Carbon Nanotube Complexation Affinity and Photoluminescence Modulation Are Independent. ACS Appl Mater Interfaces. 2017 Jun 28;9(25):21397-21405. doi: 10.1021/acsami.7b05678. Epub 2017 Jun 15.

(52) J Budhathoki-Uprety, RE Langenbacher, PV Jena, D Roxbury, DA Heller*: “A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway.” ACS Nano 11 (2017) 3875-3882.

(51) JD Harvey, PV Jena, HA Baker, GH Zerze, RM Williams, TV Galassi, D Roxbury, J Mittal, DA Heller: “A Carbon Nanotube Reporter of miRNA Hybridization Events In Vivo.” Nature Biomedical Engineering 1 (2017) 0041.

(50) A Mizrachi, Y Shamay, J Shah, S Brook, J Soong, V Rajasekhar, J Humm, J Healey, S Powell, J Baselga, DA Heller*, A Haimovitz-Friedman*, M Scaltriti*: “Tumor-specific PI3K inhibition via nanoparticle delivery in head and neck squamous cell carcinoma.” Nature Communications 8 (2017) 14292.

(49) DA Scheinberg*, J Grimm, DA Heller, EP Stater, M Bradbury, MR McDevitt: “Advances in the clinical translation of nanotechnology.” Current Opinion in Biotechnology 46 (2017) 66-73.

(48) PV Jena, TV Galassi, D Roxbury, DA Heller*: “Review—Progress toward Applications of Carbon Nanotube Photoluminescence.” ECS Journal of Solid State Science and Technology 6 (2017) M3075-M3077.

(47) TV Galassi, PV Jena, D Roxbury, DA Heller*: “Single nanotube spectral imaging to determine molar concentrations of isolated carbon nanotube species.” Analytical Chemistry 89 (2017) 1073-1077.

(46) Y Shamay, M Elkabets, H Li, J Shah, S Brook, F Wang, K Adler, E Baut, M Scaltriti, PV Jena, EE Gardner, JT Poirier, CM Rudin, J Baselga, A Haimovitz-Friedman, DA Heller*: “P-selectin is a Nanotherapeutic Delivery Target to the Tumor Microenvironment.” Science Translational Medicine 8 (2016) 345ra87. [Highlighted in Science Translational Medicine 8 (2016) 374fs11, Nature Reviews Clinical Oncology (2016), and Cancer Discovery (2016).]

(45) RM Williams, EA Jaimes*, DA Heller*: “Nanomedicines for Kidney Diseases.” Kidney International 90 (2016) 740-745.

(44) D Roxbury, PV Jena, Y Shamay, CP Horoszko, DA Heller*: “Cell Membrane Proteins Modulate the Carbon Nanotube Optical Bandgap via Surface Charge Accumulation.” ACS Nano 10 (2016) 499-506.

(43) PV Jena, Y Shamay, J Shah, D Roxbury, N Paknejad, DA Heller*: “Photoluminescent Carbon Nanotubes Interrogate the Permeability of Multicellular Tumor Spheroids.” Carbon 97 (2016) 99-109.

(42) D Roxbury, PV Jena, RM Williams, E Balazs, P Niethammer, S Marcet, M Verhaegen, S Blais-Ouellette, DA Heller*: “Hyperspectral Microscopy of Near-Infrared Fluorescence Enables 17-Chirality Carbon Nanotube Imaging.” Scientific Reports 5 (2015) 14167.

(41) RM Williams, J Shah, BD Ng, DR Minton, LJ Gudas, C Park, DA. Heller*: “Mesoscale Nanoparticles Selectively Target the Renal Proximal Tubule Epithelium.” Nano Letters 15 (2015) 2358-2364.

(40) J Budhathoki-Uprety, PV Jena, D Roxbury, DA Heller*: “Helical Polycarbodiimide Cloaking of Carbon Nanotubes Enables Inter-Nanotube Exciton Energy Transfer Modulation.” Journal of the American Chemical Society 136 (2014) 15545-15550.

(38) JJ Mulvey, EN Feinberg, S Alidori, MR McDevitt, DA Heller, DA Scheinberg*: “Synthesis, pharmacokinetics, and biological use of lysine-modified single-walled carbon nanotubes.” International Journal of Nanomedicine 9 (2014) 4245-4255.

(32) JW Kang, FT Nguyen, N Lue, RR Dasari, DA Heller*: “Measuring Uptake Dynamics of Multiple, Identifiable Carbon Nanotube Species via High-Speed Confocal Raman Imaging of Live Cells.” Nano Letters 12 (2012) 6170-6174.

Publications from work prior to MSKCC:

(39)  J Zhang, S Kruss, AJ Hilmer, S Shimzu, Z Schmois, FDL Cruz, PW Barone, NF Reuel, DA Heller, MS Strano*: “A Rapid, Direct, Quantitative, and Label-Free Detector of Cardiac Biomarker Troponin T Using Near Infrared Fluorescent Single-walled Carbon Nanotube Sensors.” Advanced Healthcare Materials 3 (2014) 412-423.

(37)  J Zhang, MP Landry, PW Barone, J-H Kim, S Lin, ZW Ulissi, D Lin, B Mu, AA Boghossian, AJ Hilmer, A Rwei, AC Hinckley, S Kruss, MA Shandell, N Nair, S Blake, F Sen, S Sen, RG Croy, D Li, K Yum, J-H Ahn, H Jin, DA Heller, JM Essigmann, D Blankschtein, MS Strano*: “Corona Phase Molecular Recognition Using Nanotube-Adsorbed Polymer Complexes.” Nature Nanotechnology 8 (2013) 959-968.

(36) Y Zhang, JM Pelet, DA Heller, J Wallas, BJ Joseph, Y Dong, D Chen, Z Gu, DG Anderson*: “Lipid-Modified Aminoglycoside Derivatives for in vivo siRNA Delivery.” Advanced Materials 25 (2013) 4641-4645.

(35) AA Boghossian, F Sen, BM Gibbons, S Sen, SM Faltermier, JP Giraldo, CT Zhang, J Zhang, DA Heller, MS Strano*: “Application of Nanoparticle Antioxidants to Enable Hyperstable Chloroplasts for Solar Energy Harvesting.” Advanced Energy Materials 3 (2013) 881-893.

(34) A Sharei, J Zoldan, A Adamo, WY Sim, N Cho, E Jackson, S Mao, S Schneider, M-J Han, A Lytton-Jean, PA Basto, S Jhunjhunwala, J Lee, DA Heller, JW Kang, GC Hartoularos, K-S Kim, DG Anderson, R Langer*, KF Jensen*: “A vector-free microfluidic platform for intracellular delivery.” Proceedings of the National Academy of Sciences 110 (2013) 2082-2087.

(33) DA Heller, Y Levi, JM Pelet, JC Doloff, J Wallas, GW Pratt, S Jiang, G Sahay, A Schroeder, JE Schroeder, Y Chyan, C Zurenko, W Querbes, M Manzano, DS Kohane, R Langer, DG Anderson*: “Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels.” Advanced Materials 25 (2013) 1449-1454. [Highlighted in Science 339 (2013) 374-375.]  

(31) AA Kayani, K Khoshmanesh, TG Nguyen, G Kostovski, AF Chrimes, M Nasabi, D Heller, A Mitchell, K Kalantar-Zadeh*: “Dynamic manipulation of modes in an optical waveguide using dielecrophoresis.” Electrophoresis 33 (2012) 2075-2085.

(30) AJ Hilmer, TP McNicholas, S Lin, J Zhang QH Wang, JD Mendenhall, C Song, DA Heller, PW Barone, D Blankschtein, MS Strano*: “The Role of Adsorbed Surfactant in the Reaction of Aryl Diazonium Salts with Single-Walled Carbon Nanotubes.” Langmuir 28 (2012) 1309-1321.

(29) A Schroeder, DA Heller, MM Winslow, JE Dahlman, GW Pratt, R Langer*, T Jacks*, DG Anderson*: “Treating metastatic cancer with nanotechnology.” Nature Reviews Cancer 12 (2012) 39-50.

(28) AA Boghossian, J Zhang, PW Barone, NF Reuel, J-H Kim, DA Heller, J-H Ahn, AJ Hilmer, A Rwei, JR Arkalgud, CT Zhang, MS Strano*: “Near-Infrared Fluorescent Sensors based on Single-Walled Carbon Nanotubes for Life Sciences Applications.” ChemSusChem 4 (2011) 848-863.

(27) DA Heller, GW Pratt, J Zhang, N Nair, AJ Hansborough, AA Boghossian, NF Reuel, PW Barone, MS Strano*: “Peptide Secondary Structure Modulates Single-Walled Carbon Nanotube Fluorescence as a Chaperone Sensor for Nitroaromatics.” Proceedings of the National Academy of Sciences 108 (2011) 8544-8549.

(26) J Zhang, AA Boghossian, PW Barone, A Rwei, J-H Kim, D Lin, DA Heller, AJ Hilmer, N Nair, NF Reuel, MS Strano*. “Single Molecule Detection of Nitric Oxide Enabled by d(AT)15 DNA Adsorbed to Near Infrared Fluorescent Single-Walled Carbon Nanotubes.” Journal of the American Chemical Society 133 (2010) 567-581.

(25) J-H Han, GLC Paulus, R Maruyama, DA Heller, W-J Kim, PW Barone, CY Lee, JH Choi, M-H Ham, C Song, C Fantini, MS Strano*.  “Exciton antennas and concentrators from core–shell and corrugated carbon nanotube filaments of homogeneous composition.”  Nature Materials 9 (2010) 833-839.

(24) M-H Ham, JH Choi, AA Boghossian, ES Jeng, RA Graff, DA Heller, AC Chang, A Mattis, TH Bayburt, YV Grinkova, AS Zeiger, KJ Van Vliet, EK Hobbie, SG Sligar, CA Wraight, MS Strano*:  “Photoelectrochemical complexes for solar energy conversion that chemically and autonomously regenerate.” Nature Chemistry 2 (2010) 929-936.

(23) H Jin, DA Heller, M Kalbacova, J-H Kim, J Zhang, AA Boghossian, N Maheshri, MS Strano*: “Detection of single-molecule H2O2 signalling from epidermal growth factor receptor using fluorescent single-walled carbon nanotubes.” Nature Nanotechnology 5 (2010) 302-309.

(22) J-H Kim, J-H Ahn, PW Barone, H Jin, J Zhang, DA Heller, MS Strano*: “A Luciferase/Single-Walled Carbon Nanotube Conjugate for Near-Infrared Fluorescent Detection of Cellular ATP.”  Angewandte Chemie 49 (2010) 1456-1459.

(21) J-H Kim, DA Heller, H Jin, PW Barone, C Song, J Zhang, LJ Trudel, GN Wogan, SR Tannenbaum, MS Strano*: “The rational design of nitric oxide selectivity in single-walled carbon nanotube near-infrared fluorescence sensors for biological detection.” Nature Chemistry 1 (2009) 473-481.

(20) DA Heller, H Jin, BM Martinez, D Patel, BM Miller, T-K Yeung, PV Jena, C Höbartner, T Ha, SK Silverman, MS Strano*: “Multi-modal optical sensing and analyte specificity via single-walled carbon nanotubes.” Nature Nanotechnology 4 (2009) 114-120.

(19) H Jin, DA Heller, R Sharma, MS Strano*: “Size-Dependent Cellular Uptake and Expulsion of Single-Walled Carbon Nanotubes: Single Particle Tracking and a Generic Uptake Model for Nanoparticles.” ACS Nano 3 (2009) 149-158.

(18) MS Strano, AA Boghossian, W-J Kim, PW Barone, ES Jeng, DA Heller, N Nair, H Jin, R Sharma, CY Lee: “The Chemistry of Single-Walled Nanotubes.” MRS Bulletin 34 (2009) 950-961.

(17) H Jin, DA Heller, J-H Kim, MS Strano*: “A Stochastic Analysis of Stepwise Fluorescence Quenching Reactions on Single-Walled Carbon Nanotubes.” Nano Letters 8 (2008) 4299-4304.

(16) H Jin, DA Heller, MS Strano*: “Single-Particle Tracking of Endocytosis and Exocytosis of Single-Walled Carbon Nanotubes in NIH-3T3 Cells.” Nano Letters 8 (2008) 1577-1585.

(15) A Rajan, MS Strano, DA Heller, T Hertel, K Schulten*: “Length-Dependent Optical Effects in Single Walled Carbon Nanotubes.” Journal of Physical Chemistry B 112 (2008) 6211-6213.

(14) H Jin, ES Jeng, DA Heller, PV Jena, R Kirmse, J Langowski, MS Strano*: “Divalent Ion and Thermally Induced DNA Conformational Polymorphism on Single-Walled Carbon Nanotubes.” Macromolecules 40 (2007) 6731-6739.

(13) JH Choi, FT Nguyen, PW Barone, DA Heller, AE Moll, D Patel, SA Boppart, MS Strano*: “Multimodal Biomedical Imaging with Asymmetric Single-Walled Carbon Nanotube/Iron Oxide Nanoparticle Complexes.” Nano Letters 7 (2007) 861-867.

(12) DA Heller, ES Jeng, T Yeung, BM Martinez, AE Moll, JB Gastala, MS Strano*: “Optical Detection of DNA Conformational Polymorphism on Single-Walled Carbon Nanotubes.” Science 311 (2006) 508-511.

(11) A Jorio, C. Fantini, MA Pimenta, DA Heller, MS Strano, MS Dresselhaus, Y Oyama, J Jiang, R Saito*: “Carbon nanotube population analysis from Raman and photoluminescence intensities.” Applied Physics Letters 88 (2006) 023109s.

(10) DA Heller, S Baik, TE Eurell, MS Strano*: “Single-Walled Carbon Nanotube Spectroscopy in Live Cells: Towards Long-Term Labels and Optical Sensors.” Advanced Materials 17 (2005) 2793-2799.

(9) EK  Lewis, WC Haaland, FT Nguyen, DA Heller, MJ Allen,  RR MacGregor, CS Berger, B Willingham, LA Burns, GBI Scott, C Kittrell, BR Johnson, RF Curl, ML Metzker*: “Color-Blind Fluorescence Detection for Four-Color DNA Sequencing.” Proceedings of the National Academy of Sciences 102 (2005) 5346-5351.

(8) RA Graff, JP Swanson, PW Barone, S Baik, DA Heller, MS Strano: “Achieving Individual Nanotube Dispersion at High Loading in Single-Walled Carbon Nanotube Composites.” Advanced Materials 17 (2005) 980-984.

(7) DA Heller, PW Barone, MS Strano*: “Sonication-induced changes in chiral distribution: A complication to the use of single-walled carbon nanotube fluorescence for determining species distribution.” Carbon 43 (2005) 651-653.           

(6) PW Barone, S Baik, DA Heller, MS Strano*: “Near-infrared optical sensors based on single-walled carbon nanotubes.” Nature Materials 4 (2005) 86-92.

(5) DA Heller, V Garga, KJ Kelleher, T-C Lee, S Mahbubani, LA Sigworth, TR Lee*, MA Rea*: “Patterned networks of mouse hippocampal neurons on peptide-coated gold surfaces.” Biomaterials 26 (2005) 883-889.

(4) DA Heller, RM Mayrhofer, S Baik, YV Grinkova, ML Usrey, MS Strano*: “Concomitant length and diameter separation of single-walled carbon nanotubes.”  Journal of the American Chemical Society 126 (2004) 14567-14573.

(3) DA Heller, PW Barone, JP Swanson, RM Mayrhofer, MS Strano*: “Using Raman spectroscopy to elucidate the aggregation state of single-walled carbon nanotubes.” Journal of Physical Chemistry B 108 (2004) 6905-6909.

(2) MS Strano*, M Zheng, A Jagota, GB Onoa, DA Heller, PW Barone, ML Usrey: “Understanding the nature of the DNA-assisted separation of single-walled carbon nanotubes using fluorescence and Raman spectroscopy.” Nano Letters 4 (2004) 543-550.

(1) SK Doorn, DA Heller, PW Barone, ML Usrey, MS Strano*: “Resonant Raman excitation profiles of individually dispersed single walled carbon nanotubes in solution.” Applied Physics A-Materials Science & Processing 78 (2004) 1147-55.