The Daniel Heller Lab: Publications

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View a full listing of Daniel A. Heller’s journal articles.


Selected Publications

J Budhathoki-Uprety, J Shah, JA Korsen, AE Wayne, TV Galassi, JR Cohen, JD Harvey, PV Jena, LV Ramanathan, EA Jaimes, DA Heller*. “Synthetic Molecular Recognition Nanosensor Paint for Microalbuminuria.” Nature Communications 10 (2019) 3605.

TV Galassi, PV Jena, J Shah, G Ao, E Molitor, Y Bram, A Frankel, J Park, J Jessurun, DS Ory, A Haimovitz-Friedman, D Roxbury, J Mittal, M Zheng, R E Schwartz, DA Heller*. “An Optical Nanoreporter of Endolysosomal Lipid Accumulation Reveals Enduring Effects of Diet on Hepatic Macrophages In Vivo.” Science Translational Medicine 10 (2018) eaar2680.

RM Williams, C Lee, TV Galassi, JD Harvey, R Leicher, M Sirenko, M Dorso, J Shah, N Olvera, F Dao, DA Levine,DA Heller*. “Non-Invasive Ovarian Cancer Biomarker Detection via an Optical Nanosensor Implant.” Science Advances 4 (2018) eaaq1090.

Y Shamay, J Shah, DF Tschaharganeh, D Roxbury, J Budhathoki-Uprety, M Işık, A Mizrachi, K Nawaly, JL Sugarman, E Baut, MR Neiman, DC Johnson, R Sridharan, KL Chu, VK Rajasekhar, JD Chodera, SW Lowe, DA Heller*, “Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines” Nature Materials 4 (2018) 361-368.

Jena PV, Roxbury D, Galassi TV, Akkari L, Horoszko CP, Iaea DB, Budhathoki-Uprety J, Pipalia N, Haka AS, Harvey JD, Mittal J, Maxfield FR, Joyce JA, Heller DA. A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux. ACS Nano 11 (2017) 10689-1070.

J Budhathoki-Uprety, RE Langenbacher, PV Jena, D Roxbury, DA Heller*: “A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway.” ACS Nano 11 (2017) 3875-3882.

JD Harvey, PV Jena, HA Baker, GH Zerze, RM Williams, TV Galassi, D Roxbury, J Mittal, DA Heller: “A Carbon Nanotube Reporter of miRNA Hybridization Events In Vivo.” Nature Biomedical Engineering 1 (2017) 0041.

A Mizrachi, Y Shamay, J Shah, S Brook, J Soong, V Rajasekhar, J Humm, J Healey, S Powell, J Baselga, DA Heller*, A Haimovitz-Friedman*, M Scaltriti*: “Tumor-specific PI3K inhibition via nanoparticle delivery in head and neck squamous cell carcinoma.” Nature Communications 8 (2017) 14292.

Y Shamay, M Elkabets, H Li, J Shah, S Brook, F Wang, K Adler, E Baut, M Scaltriti, PV Jena, EE Gardner, JT Poirier, CM Rudin, J Baselga, A Haimovitz-Friedman, DA Heller*: “P-selectin is a Nanotherapeutic Delivery Target to the Tumor Microenvironment.” Science Translational Medicine 8 (2016) 345ra8 [Highlighted in Science Translational Medicine 8 (2016) 374fs11, Nature Reviews Clinical Oncology (2016), and Cancer Discovery (2016).]


Full Publications List

(67) J Budhathoki-Uprety, J Shah, JA Korsen, AE Wayne, TV Galassi, JR Cohen, JD Harvey, PV Jena, LV Ramanathan, EA Jaimes, DA Heller*. “Synthetic Molecular Recognition Nanosensor Paint for Microalbuminuria.” Nature Communications 10 (2019) 3605. 

(66) H Kodama, Y Shamay, Y Kimura, J Shah, SB Solomon, D Heller, G Srimathveeravalli*. “Electroporation-induced changes in tumor vasculature and microenvironment can promote the delivery and increase the efficacy of sorafenib nanoparticles”. Bioelectrochemistry 130 (2019) 107328. 

(65) JD Harvey, RM Williams, KM. Tully, HA Baker, Y Shamay, DA Heller*. “An in Vivo Nanosensor Measures Compartmental Doxorubicin Exposure.” Nano Letters (2019).

(64) JD Harvey, HA Baker, MV Ortiz, A Kentsis, DA Heller*. “HIV Detection via a Carbon Nanotube RNA Sensor.” ACS Sensors 4 (2019) 1236-1244.

(63) TV Galassi, PV Jena, J Shah, G Ao, E Molitor, Y Bram, A Frankel, J Park, J Jessurun, DS Ory, A Haimovitz-Friedman, D Roxbury, J Mittal, M Zheng, R E Schwartz, DA Heller*. “An Optical Nanoreporter of Endolysosomal Lipid Accumulation Reveals Enduring Effects of Diet on Hepatic Macrophages In Vivo.” Science Translational Medicine 10 (2018) eaar2680. 

(62) RM Williams, C Lee, DA Heller*. “A Fluorescent Carbon Nanotube Sensor Detects the Metastatic Prostate Cancer Biomarker uPA.” ACS Sensors 3 (2018) 1838–1845.

(61) JD Harvey, GH Zerze, KM Tully, J Mittal, DA Heller*. “Electrostatic Screening Modulates Analyte Binding and Emission of Carbon Nanotubes.” Journal of Physical Chemistry C (2018)

(60) RM Williams, C Lee, TV Galassi, JD Harvey, R Leicher, M Sirenko, M Dorso, J Shah, N Olvera, F Dao, DA Levine, DA Heller*. “Non-Invasive Ovarian Cancer Biomarker Detection via an Optical Nanosensor Implant.” Science Advances 4 (2018) eaaq1090.

(59) Y Shamay, J Shah, DF Tschaharganeh, D Roxbury, J Budhathoki-Uprety, M Işık, A Mizrachi, K Nawaly, JL Sugarman, E Baut, MR Neiman, DC Johnson, R Sridharan, KL Chu, VK Rajasekhar, JD Chodera, SW Lowe, DA Heller*, “Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines” Nature Materials (2018)

(58) RM Williams, J Shah, HS Tian, Xi Chen, F Geissman, EA Jaimes, DA Heller*, “Selective Nanoparticle Targeting of the Renal Tubules.” Hypertension 71 (2018) 87-94.

[Highlighted in Hypertension Perspective, Yap, et. al., 2017]

(57) JD Harvey, HA. Baker, E Mercer, J Budhathoki-Uprety, DA Heller*, “Control of carbon nanotube solvatochromic response to chemotherapeutic agents.” ACS Applied Materials & Interfaces 9 (2017) 37947-37953.

(56) Sims CM, Hanna SK, Heller DA, Horoszko CP, Johnson ME, Montoro Bustos AR, Reipa V, Riley KR, Nelson BC. Redox-active nanomaterials for nanomedicine applications. Nanoscale. 2017 Oct 19;9(40):15226-15251. doi: 10.1039/c7nr05429g. Review.

(55) Jena PV, Roxbury D, Galassi TV, Akkari L, Horoszko CP, Iaea DB, Budhathoki-Uprety J, Pipalia N, Haka AS, Harvey JD, Mittal J, Maxfield FR, Joyce JA, Heller DA. A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux. ACS Nano. 2017 Sep 12. doi: 10.1021/acsnano.7b04743. [Epub ahead of print]

(54) Harvey JD, Baker HA, Mercer E, Budhathoki-Uprety J, Heller DA. Control of Carbon Nanotube Solvatochromic Response to Chemotherapeutic Agents. ACS Appl Mater Interfaces. 2017 Nov 1;9(43):37947-37953. doi: 10.1021/acsami.7b12015. Epub 2017 Oct 19.

(53) Jena PV, Safaee MM, Heller DA, Roxbury D. DNA-Carbon Nanotube Complexation Affinity and Photoluminescence Modulation Are Independent. ACS Appl Mater Interfaces. 2017 Jun 28;9(25):21397-21405. doi: 10.1021/acsami.7b05678. Epub 2017 Jun 15.

(52) J Budhathoki-Uprety, RE Langenbacher, PV Jena, D Roxbury, DA Heller*: “A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway.” ACS Nano 11 (2017) 3875-3882.

(51) JD Harvey, PV Jena, HA Baker, GH Zerze, RM Williams, TV Galassi, D Roxbury, J Mittal, DA Heller: “A Carbon Nanotube Reporter of miRNA Hybridization Events In Vivo.” Nature Biomedical Engineering 1 (2017) 0041.

(50) A Mizrachi, Y Shamay, J Shah, S Brook, J Soong, V Rajasekhar, J Humm, J Healey, S Powell, J Baselga, DA Heller*, A Haimovitz-Friedman*, M Scaltriti*: “Tumor-specific PI3K inhibition via nanoparticle delivery in head and neck squamous cell carcinoma.” Nature Communications 8 (2017) 14292.

(49) DA Scheinberg*, J Grimm, DA Heller, EP Stater, M Bradbury, MR McDevitt: “Advances in the clinical translation of nanotechnology.” Current Opinion in Biotechnology 46 (2017) 66-73.

(48) PV Jena, TV Galassi, D Roxbury, DA Heller*: “Review—Progress toward Applications of Carbon Nanotube Photoluminescence.” ECS Journal of Solid State Science and Technology 6 (2017) M3075-M3077.

(47) TV Galassi, PV Jena, D Roxbury, DA Heller*: “Single nanotube spectral imaging to determine molar concentrations of isolated carbon nanotube species.” Analytical Chemistry 89 (2017) 1073-1077.

(46) Y Shamay, M Elkabets, H Li, J Shah, S Brook, F Wang, K Adler, E Baut, M Scaltriti, PV Jena, EE Gardner, JT Poirier, CM Rudin, J Baselga, A Haimovitz-Friedman, DA Heller*: “P-selectin is a Nanotherapeutic Delivery Target to the Tumor Microenvironment.” Science Translational Medicine 8 (2016) 345ra87. [Highlighted in Science Translational Medicine 8 (2016) 374fs11, Nature Reviews Clinical Oncology (2016), and Cancer Discovery (2016).]

(45) RM Williams, EA Jaimes*, DA Heller*: “Nanomedicines for Kidney Diseases.” Kidney International 90 (2016) 740-745.

(44) D Roxbury, PV Jena, Y Shamay, CP Horoszko, DA Heller*: “Cell Membrane Proteins Modulate the Carbon Nanotube Optical Bandgap via Surface Charge Accumulation.” ACS Nano 10 (2016) 499-506.

(43) PV Jena, Y Shamay, J Shah, D Roxbury, N Paknejad, DA Heller*: “Photoluminescent Carbon Nanotubes Interrogate the Permeability of Multicellular Tumor Spheroids.” Carbon 97 (2016) 99-109.

(42) D Roxbury, PV Jena, RM Williams, E Balazs, P Niethammer, S Marcet, M Verhaegen, S Blais-Ouellette, DA Heller*: “Hyperspectral Microscopy of Near-Infrared Fluorescence Enables 17-Chirality Carbon Nanotube Imaging.” Scientific Reports 5 (2015) 14167.

(41) RM Williams, J Shah, BD Ng, DR Minton, LJ Gudas, C Park, DA. Heller*: “Mesoscale Nanoparticles Selectively Target the Renal Proximal Tubule Epithelium.” Nano Letters 15 (2015) 2358-2364.

(40) J Budhathoki-Uprety, PV Jena, D Roxbury, DA Heller*: “Helical Polycarbodiimide Cloaking of Carbon Nanotubes Enables Inter-Nanotube Exciton Energy Transfer Modulation.” Journal of the American Chemical Society 136 (2014) 15545-15550.

(38) JJ Mulvey, EN Feinberg, S Alidori, MR McDevitt, DA Heller, DA Scheinberg*: “Synthesis, pharmacokinetics, and biological use of lysine-modified single-walled carbon nanotubes.” International Journal of Nanomedicine 9 (2014) 4245-4255.

(32) JW Kang, FT Nguyen, N Lue, RR Dasari, DA Heller*: “Measuring Uptake Dynamics of Multiple, Identifiable Carbon Nanotube Species via High-Speed Confocal Raman Imaging of Live Cells.” Nano Letters 12 (2012) 6170-6174.

Publications from work prior to MSKCC:

(39)  J Zhang, S Kruss, AJ Hilmer, S Shimzu, Z Schmois, FDL Cruz, PW Barone, NF Reuel, DA Heller, MS Strano*: “A Rapid, Direct, Quantitative, and Label-Free Detector of Cardiac Biomarker Troponin T Using Near Infrared Fluorescent Single-walled Carbon Nanotube Sensors.” Advanced Healthcare Materials 3 (2014) 412-423.

(37)  J Zhang, MP Landry, PW Barone, J-H Kim, S Lin, ZW Ulissi, D Lin, B Mu, AA Boghossian, AJ Hilmer, A Rwei, AC Hinckley, S Kruss, MA Shandell, N Nair, S Blake, F Sen, S Sen, RG Croy, D Li, K Yum, J-H Ahn, H Jin, DA Heller, JM Essigmann, D Blankschtein, MS Strano*: “Corona Phase Molecular Recognition Using Nanotube-Adsorbed Polymer Complexes.” Nature Nanotechnology 8 (2013) 959-968.

(36) Y Zhang, JM Pelet, DA Heller, J Wallas, BJ Joseph, Y Dong, D Chen, Z Gu, DG Anderson*: “Lipid-Modified Aminoglycoside Derivatives for in vivo siRNA Delivery.” Advanced Materials 25 (2013) 4641-4645.

(35) AA Boghossian, F Sen, BM Gibbons, S Sen, SM Faltermier, JP Giraldo, CT Zhang, J Zhang, DA Heller, MS Strano*: “Application of Nanoparticle Antioxidants to Enable Hyperstable Chloroplasts for Solar Energy Harvesting.” Advanced Energy Materials 3 (2013) 881-893.

(34) A Sharei, J Zoldan, A Adamo, WY Sim, N Cho, E Jackson, S Mao, S Schneider, M-J Han, A Lytton-Jean, PA Basto, S Jhunjhunwala, J Lee, DA Heller, JW Kang, GC Hartoularos, K-S Kim, DG Anderson, R Langer*, KF Jensen*: “A vector-free microfluidic platform for intracellular delivery.” Proceedings of the National Academy of Sciences 110 (2013) 2082-2087.

(33) DA Heller, Y Levi, JM Pelet, JC Doloff, J Wallas, GW Pratt, S Jiang, G Sahay, A Schroeder, JE Schroeder, Y Chyan, C Zurenko, W Querbes, M Manzano, DS Kohane, R Langer, DG Anderson*: “Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels.” Advanced Materials 25 (2013) 1449-1454. [Highlighted in Science 339 (2013) 374-375.]  

(31) AA Kayani, K Khoshmanesh, TG Nguyen, G Kostovski, AF Chrimes, M Nasabi, D Heller, A Mitchell, K Kalantar-Zadeh*: “Dynamic manipulation of modes in an optical waveguide using dielecrophoresis.” Electrophoresis 33 (2012) 2075-2085.

(30) AJ Hilmer, TP McNicholas, S Lin, J Zhang QH Wang, JD Mendenhall, C Song, DA Heller, PW Barone, D Blankschtein, MS Strano*: “The Role of Adsorbed Surfactant in the Reaction of Aryl Diazonium Salts with Single-Walled Carbon Nanotubes.” Langmuir 28 (2012) 1309-1321.

(29) A Schroeder, DA Heller, MM Winslow, JE Dahlman, GW Pratt, R Langer*, T Jacks*, DG Anderson*: “Treating metastatic cancer with nanotechnology.” Nature Reviews Cancer 12 (2012) 39-50.

(28) AA Boghossian, J Zhang, PW Barone, NF Reuel, J-H Kim, DA Heller, J-H Ahn, AJ Hilmer, A Rwei, JR Arkalgud, CT Zhang, MS Strano*: “Near-Infrared Fluorescent Sensors based on Single-Walled Carbon Nanotubes for Life Sciences Applications.” ChemSusChem 4 (2011) 848-863.

(27) DA Heller, GW Pratt, J Zhang, N Nair, AJ Hansborough, AA Boghossian, NF Reuel, PW Barone, MS Strano*: “Peptide Secondary Structure Modulates Single-Walled Carbon Nanotube Fluorescence as a Chaperone Sensor for Nitroaromatics.” Proceedings of the National Academy of Sciences 108 (2011) 8544-8549.

(26) J Zhang, AA Boghossian, PW Barone, A Rwei, J-H Kim, D Lin, DA Heller, AJ Hilmer, N Nair, NF Reuel, MS Strano*. “Single Molecule Detection of Nitric Oxide Enabled by d(AT)15 DNA Adsorbed to Near Infrared Fluorescent Single-Walled Carbon Nanotubes.” Journal of the American Chemical Society 133 (2010) 567-581.

(25) J-H Han, GLC Paulus, R Maruyama, DA Heller, W-J Kim, PW Barone, CY Lee, JH Choi, M-H Ham, C Song, C Fantini, MS Strano*.  “Exciton antennas and concentrators from core–shell and corrugated carbon nanotube filaments of homogeneous composition.”  Nature Materials 9 (2010) 833-839.

(24) M-H Ham, JH Choi, AA Boghossian, ES Jeng, RA Graff, DA Heller, AC Chang, A Mattis, TH Bayburt, YV Grinkova, AS Zeiger, KJ Van Vliet, EK Hobbie, SG Sligar, CA Wraight, MS Strano*:  “Photoelectrochemical complexes for solar energy conversion that chemically and autonomously regenerate.” Nature Chemistry 2 (2010) 929-936.

(23) H Jin, DA Heller, M Kalbacova, J-H Kim, J Zhang, AA Boghossian, N Maheshri, MS Strano*: “Detection of single-molecule H2O2 signalling from epidermal growth factor receptor using fluorescent single-walled carbon nanotubes.” Nature Nanotechnology 5 (2010) 302-309.

(22) J-H Kim, J-H Ahn, PW Barone, H Jin, J Zhang, DA Heller, MS Strano*: “A Luciferase/Single-Walled Carbon Nanotube Conjugate for Near-Infrared Fluorescent Detection of Cellular ATP.”  Angewandte Chemie 49 (2010) 1456-1459.

(21) J-H Kim, DA Heller, H Jin, PW Barone, C Song, J Zhang, LJ Trudel, GN Wogan, SR Tannenbaum, MS Strano*: “The rational design of nitric oxide selectivity in single-walled carbon nanotube near-infrared fluorescence sensors for biological detection.” Nature Chemistry 1 (2009) 473-481.

(20) DA Heller, H Jin, BM Martinez, D Patel, BM Miller, T-K Yeung, PV Jena, C Höbartner, T Ha, SK Silverman, MS Strano*: “Multi-modal optical sensing and analyte specificity via single-walled carbon nanotubes.” Nature Nanotechnology 4 (2009) 114-120.

(19) H Jin, DA Heller, R Sharma, MS Strano*: “Size-Dependent Cellular Uptake and Expulsion of Single-Walled Carbon Nanotubes: Single Particle Tracking and a Generic Uptake Model for Nanoparticles.” ACS Nano 3 (2009) 149-158.

(18) MS Strano, AA Boghossian, W-J Kim, PW Barone, ES Jeng, DA Heller, N Nair, H Jin, R Sharma, CY Lee: “The Chemistry of Single-Walled Nanotubes.” MRS Bulletin 34 (2009) 950-961.

(17) H Jin, DA Heller, J-H Kim, MS Strano*: “A Stochastic Analysis of Stepwise Fluorescence Quenching Reactions on Single-Walled Carbon Nanotubes.” Nano Letters 8 (2008) 4299-4304.

(16) H Jin, DA Heller, MS Strano*: “Single-Particle Tracking of Endocytosis and Exocytosis of Single-Walled Carbon Nanotubes in NIH-3T3 Cells.” Nano Letters 8 (2008) 1577-1585.

(15) A Rajan, MS Strano, DA Heller, T Hertel, K Schulten*: “Length-Dependent Optical Effects in Single Walled Carbon Nanotubes.” Journal of Physical Chemistry B 112 (2008) 6211-6213.

(14) H Jin, ES Jeng, DA Heller, PV Jena, R Kirmse, J Langowski, MS Strano*: “Divalent Ion and Thermally Induced DNA Conformational Polymorphism on Single-Walled Carbon Nanotubes.” Macromolecules 40 (2007) 6731-6739.

(13) JH Choi, FT Nguyen, PW Barone, DA Heller, AE Moll, D Patel, SA Boppart, MS Strano*: “Multimodal Biomedical Imaging with Asymmetric Single-Walled Carbon Nanotube/Iron Oxide Nanoparticle Complexes.” Nano Letters 7 (2007) 861-867.

(12) DA Heller, ES Jeng, T Yeung, BM Martinez, AE Moll, JB Gastala, MS Strano*: “Optical Detection of DNA Conformational Polymorphism on Single-Walled Carbon Nanotubes.” Science 311 (2006) 508-511.

(11) A Jorio, C. Fantini, MA Pimenta, DA Heller, MS Strano, MS Dresselhaus, Y Oyama, J Jiang, R Saito*: “Carbon nanotube population analysis from Raman and photoluminescence intensities.” Applied Physics Letters 88 (2006) 023109s.

(10) DA Heller, S Baik, TE Eurell, MS Strano*: “Single-Walled Carbon Nanotube Spectroscopy in Live Cells: Towards Long-Term Labels and Optical Sensors.” Advanced Materials 17 (2005) 2793-2799.

(9) EK  Lewis, WC Haaland, FT Nguyen, DA Heller, MJ Allen,  RR MacGregor, CS Berger, B Willingham, LA Burns, GBI Scott, C Kittrell, BR Johnson, RF Curl, ML Metzker*: “Color-Blind Fluorescence Detection for Four-Color DNA Sequencing.” Proceedings of the National Academy of Sciences 102 (2005) 5346-5351.

(8) RA Graff, JP Swanson, PW Barone, S Baik, DA Heller, MS Strano: “Achieving Individual Nanotube Dispersion at High Loading in Single-Walled Carbon Nanotube Composites.” Advanced Materials 17 (2005) 980-984.

(7) DA Heller, PW Barone, MS Strano*: “Sonication-induced changes in chiral distribution: A complication to the use of single-walled carbon nanotube fluorescence for determining species distribution.” Carbon 43 (2005) 651-653.           

(6) PW Barone, S Baik, DA Heller, MS Strano*: “Near-infrared optical sensors based on single-walled carbon nanotubes.” Nature Materials 4 (2005) 86-92.

(5) DA Heller, V Garga, KJ Kelleher, T-C Lee, S Mahbubani, LA Sigworth, TR Lee*, MA Rea*: “Patterned networks of mouse hippocampal neurons on peptide-coated gold surfaces.” Biomaterials 26 (2005) 883-889.

(4) DA Heller, RM Mayrhofer, S Baik, YV Grinkova, ML Usrey, MS Strano*: “Concomitant length and diameter separation of single-walled carbon nanotubes.”  Journal of the American Chemical Society 126 (2004) 14567-14573.

(3) DA Heller, PW Barone, JP Swanson, RM Mayrhofer, MS Strano*: “Using Raman spectroscopy to elucidate the aggregation state of single-walled carbon nanotubes.” Journal of Physical Chemistry B 108 (2004) 6905-6909.

(2) MS Strano*, M Zheng, A Jagota, GB Onoa, DA Heller, PW Barone, ML Usrey: “Understanding the nature of the DNA-assisted separation of single-walled carbon nanotubes using fluorescence and Raman spectroscopy.” Nano Letters 4 (2004) 543-550.

(1) SK Doorn, DA Heller, PW Barone, ML Usrey, MS Strano*: “Resonant Raman excitation profiles of individually dispersed single walled carbon nanotubes in solution.” Applied Physics A-Materials Science & Processing 78 (2004) 1147-55.